Strong anti-oxidation DHA microcapsule and preparation method thereof

An anti-oxidation and anti-oxidant technology, applied in the direction of microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of weak anti-oxidation, waste, and poor product stability, and achieve enhanced product anti-oxidation and product shelf life. The effect of prolonged

Inactive Publication Date: 2010-03-17
江苏怀仁生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, microcapsule technology has been applied to fish oil products, such as the preparation method of DHA fish oil capsules mentioned in the invention patent application document with the publication number CN1927050A, but the fish oil microcapsules produced by the prior art generally have

Method used

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  • Strong anti-oxidation DHA microcapsule and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] DHA Fish Oil 15%

[0024] Gelatin 60%

[0025] Vitamin C 0.1%

[0026] Lecithin 0.1%

[0027] Dextrin 24.8%

[0028] Appropriate amount of purified water

[0029] Preparation

[0030] 1) Prepare the oil phase solution: mix DHA fish oil and vitamin C according to the ratio and stir evenly.

[0031] 2) Preparation of aqueous phase solution: mix gelatin, dextrin and lecithin in water according to the proportion, stir and disperse evenly.

[0032] 3) Preparation of emulsion: Slowly add the oil phase solution into the water phase solution and stir at high speed to emulsify for a certain period of time.

[0033] 4) High-pressure homogenization: the above-mentioned emulsion is homogenized under high pressure for more than 3 times under a pressure of 40-50 MPa.

[0034] 5) Spray granulation: Add the above homogenized emulsion into the centrifugal spray dryer, the air inlet temperature is 150-190°C, the outlet air temperature is 70-80°C, and the nozzle speed is 20,000-30,...

Embodiment 2

[0037] DHA Fish Oil 20%

[0038] Starch Octenylsuccinate 50%

[0039] Vitamin C 0.1%

[0040] Vitamin E 0.1%

[0041] Sodium Caseinate 29.8%

[0042] Appropriate amount of purified water

[0043] Preparation

[0044] 1) Prepare the oil phase solution: mix DHA fish oil and vitamin C according to the ratio and stir evenly.

[0045] 2) Preparation of water phase solution: mix octenyl succinate starch, sodium caseinate and vitamin E in water according to the proportion, stir and disperse evenly.

[0046] 3) Preparation of emulsion: Slowly add the oil phase solution into the water phase solution and stir at high speed to emulsify for a certain period of time.

[0047] 4) High-pressure homogenization: the above-mentioned emulsion is homogenized under high pressure for more than 3 times under a pressure of 40-50 MPa.

[0048] 5) Spray granulation: Add the above homogenized emulsion into a centrifugal spray dryer with an inlet air temperature of 150-190°C, an outlet air tempera...

Embodiment 3

[0051] DHA Fish Oil 25%

[0052] Starch Octenylsuccinate 45%

[0053] Tea polyphenols 0.05%

[0054] Lecithin 0.15%

[0055] Sodium Caseinate 29.8%

[0056] Appropriate amount of purified water

[0057] Preparation

[0058] 1) Preparation of oil phase solution: mix DHA fish oil and tea polyphenols according to the proportion and stir evenly.

[0059] 2) Preparation of aqueous phase solution: Mix octenyl succinate starch, sodium caseinate and lecithin in water according to the proportion, stir and disperse evenly.

[0060] 3) Preparation of emulsion: Slowly add the oil phase solution into the water phase solution and stir at high speed to emulsify for a certain period of time.

[0061] 4) High-pressure homogenization: the above-mentioned emulsion is homogenized under high pressure for more than 3 times under a pressure of 40-50 MPa.

[0062] 5) Spray granulation: Add the above homogenized emulsion into a centrifugal spray dryer with an inlet air temperature of 150-190°C,...

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Abstract

The invention relates to a strong anti-oxidation DHA microcapsule. The microcapsule comprises the following components in percentage by weight: 10 to 30 percent of DHA fish oil, 0.02 to 0.2 percent ofantioxidant, 10 to 60 percent of wall material, and 5 to 30 percent of auxiliary wall material 5. The invention also relates to a method for preparing the strong anti-oxidation DHA microcapsule. On the basis of the prior process, the microcapsule is prepared by adding the antioxidant to oil phase and water phase respectively and performing emulsification, high-pressure homogenization, improved spray granulation and cold-air boiling-drying. The newly added antioxidant can produce better anti-oxidation effects and greatly improve the oxidation stability of the DHA microcapsule so as to prolongthe shelf life of products, and the improved spray granulation and the cold-air boiling-drying process can increase the yield of the DHA microcapsule. The DHA microcapsule can be used in the fields ofmedicines, foods, beverages and the like.

Description

technical field [0001] The invention relates to a preparation and a preparation method thereof, in particular to a strong antioxidant DHA microcapsule and a preparation method thereof. Background technique [0002] DHA (docosahexaenoic acid) is an important lipid component of cell membranes, retinas, and brains. It plays an important role in the formation of cranial nerves, maintaining the normal function of cranial nerves, and delaying the decline of cranial nerves; the metabolite of EPA Eicosanic acid derivatives can effectively regulate the synthesis of arachidonic acid, prostaglandins, leukotrienes and other biologically active substances, so as to prevent and treat cardiovascular and cerebrovascular diseases, inflammation, diseases of the reproductive system and enhance the body's autoimmunity. [0003] But DHA and EPA are very easily oxidized by oxygen in the air, which brings certain troubles to their reprocessing and preservation. Encapsulation of DHA fish oil with ...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/202A61P25/00A61P3/02
Inventor 葛海涛张杰唐俊
Owner 江苏怀仁生物科技有限公司
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