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Chitosan entrapment body of nano-scale arsenous acid and manufacturing method thereof

A nano-chitosan, nano-sized technology, which is applied in the directions of non-active ingredient medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc., can solve the problems of high toxicity and side effects, low bioavailability of arsenic preparations, etc. , to achieve the effect of more active centers, excellent biomedical characteristics, and enhanced targeting

Inactive Publication Date: 2010-04-21
广汉恒宇新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Today, the problem we are facing is that there are many problems such as low bioavailability and large toxic and side effects of arsenic preparations in clinical application, which need to be solved urgently.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) The chitosan-wrapped carrier of type A nano-sized arsenous acid, by 100 parts by weight, consists of:

[0040] Nano-sized chitosan 0.361 parts by weight

[0041] Nano-sized arsenous acid 0.0018 parts by weight

[0042] Sodium sulfate (ionotrope) 0.0024 parts by weight

[0043] Span-80 (surfactant) 0.0188 parts by weight

[0044] Acetic acid 0.361 parts by weight

[0045] Fatty alcohol polyoxyethylene ether 0.289 parts by weight

[0046] The balance is 98.966 parts by weight of deionized water

[0047] 2) The manufacture method of the chitosan-wrapped carrier of the A-type nano-sized arsenous acid, the steps are as follows:

[0048] (1) Preparation process of arsenous acid pre-dispersed intermediate:

[0049] 1. Take 0.1 parts by weight of Span-80 (surfactant) and 200 parts by weight of deionized water, place them in a reaction kettle equipped with a backflow condenser, adjust the stirring speed to 2000 rpm, Accompanied by stirring for 30 minutes;

[0050] 2. Th...

Embodiment 2

[0062] 1) The chitosan-wrapped carrier of B-type nano-sized arsenous acid, by 100 parts by weight, consists of:

[0063] Nano-sized chitosan 0.238 parts by weight

[0064] Nano-sized arsenous acid 0.00115 parts by weight

[0065] Sodium tripolyphosphate (ionotrope) 0.00024 parts by weight

[0066] Tween-80 (surfactant) 0.006 parts by weight

[0067] Lactic acid 0.238 parts by weight

[0068] Fatty alcohol polyoxyethylene ether 0.19 parts by weight

[0069] The balance is 99.088 parts by weight of deionized water

[0070] 2) The manufacture method of the chitosan-wrapped carrier of the B-type nano-sized arsenous acid, the steps are as follows:

[0071] (1) Preparation process of arsenous acid pre-dispersed intermediate:

[0072] 1) Take 0.12 parts by weight of Tween-80 (surfactant) and 500 parts by weight of deionized water, place them in a reaction kettle equipped with a backflow condenser, adjust the stirring speed to 2000 rpm Stir for 30 minutes under the bar;

[007...

Embodiment 3

[0085] 1) The chitosan-wrapped carrier of C-type nano-sized arsenous acid, by 100 parts by weight, consists of:

[0086] Nano-sized chitosan 0.322 parts by weight

[0087] Nano-sized arsenous acid 0.00125 parts by weight

[0088] Sodium citrate (ionotrope) 0.02 parts by weight

[0089] Castor oil polyoxyethylene ether (surfactant) 0.025 parts by weight

[0090] 0.322 parts by weight of acetic acid

[0091] Fatty alcohol polyoxyethylene ether 0.258 parts by weight

[0092] The balance is deionized water. 99.052 parts by weight

[0093] 2) The manufacture method of the chitosan-wrapped carrier of the C-type nano-sized arsenous acid, the steps are as follows:

[0094] (1) Preparation process of arsenous acid pre-dispersed intermediate:

[0095] 1), get castor oil polyoxyethylene ether (surfactant) 1.0 weight part, deionized water 1000 weight part, be placed in the reactor that is equipped with reverse flow condenser, stir speed is adjusted to 2000 rev / min, in Stir for 30 ...

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PUM

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Abstract

The invention provides a chitosan entrapment body of nano-scale arsenous acid, which comprises the following components in part by weight: 0.2 to 0.4 part of nano chitosan, 0.001 to 0.002 part of nano arsenous acid, 0.00024 to 0.02 part of ion shift variant agent, 0.005 to 0.03 part of surface active agent, 0.2 to 0.4 part of lactic acid or acetic acid, 0.1 to 0.3 part of fatty alcohol polyethenoxy ether, and the balance of deionized water. An integration process of three highly difficult reactions including the preparation of an arsenous acid pre-dispersed intermediate, the preparation of an active nano chitosan three-dimensional network colloid and the entrapment to the nano arsenous acid by the active nano chitosan three-dimensional network colloid is achieved by a 'one-step method', and nano arsenous acid particles in the manufactured chitosan entrapment body have the main area particle size distribution of between 20 and 50 nanometers and show the characteristics of the arsenous acid. The chitosan entrapment body of the nano-scale arsenous acid has the advantages of high bioavailability, enhanced slow-release property, reduced dosage, low toxic or side effect and enhanced anti-cancer curative effect, and provides a selection path with high-tech synthesis for arsenic medicaments.

Description

technical field [0001] The invention belongs to the field of new drug preparation, and specifically relates to a nano-sized arsenous acid chitosan-wrapped carrier and a manufacturing method thereof. Background technique [0002] Arsenic drugs have a long history of application in traditional medicine in my country. In recent years, extensive clinical practice and basic research have shown that arsenic trioxide preparations have curative effects on acute promyelocytic leukemia (APL) and various malignant hematological diseases and solid tumors. Arsenic drugs have shown important, It has broad application prospects and has become a hot spot in the field of global anti-tumor research. Today, the problem facing the clinical application of arsenic preparations is low bioavailability, large toxic and side effects and many other problems that need to be solved urgently. [0003] Modern nanotechnology is based on the fact that when material particles are processed to nanometer siz...

Claims

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Application Information

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IPC IPC(8): A61K33/36A61K9/14A61K47/36A61P35/00A61P35/02
Inventor 龚正烈李正军龚葆红
Owner 广汉恒宇新材料有限公司
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