Amphipathic super-paramagnetic and magnetically resonant contrast agent and preparation method thereof

A magnetic resonance contrast agent and superparamagnetic technology, which is used in the preparation of contrast agents and in the field of amphiphilic superparamagnetic magnetic resonance contrast agents to achieve the effects of reducing toxicity, good reproducibility and high saturation magnetization

Inactive Publication Date: 2010-05-12
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the current literature, there are few reports on the application of iron-platinum nanoparticles in biological imaging, so we need to study this material more in-depth

Method used

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  • Amphipathic super-paramagnetic and magnetically resonant contrast agent and preparation method thereof
  • Amphipathic super-paramagnetic and magnetically resonant contrast agent and preparation method thereof
  • Amphipathic super-paramagnetic and magnetically resonant contrast agent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Embodiment 1: preparation Fe (acac) 3

[0031] Weigh FeCl 3(1.62g, 10mmol) was dissolved in 10ml of water, then added acetylacetone (6.15ml, 60mmol) in the reaction solution, under the condition of room temperature, magnetic stirring, stop stirring after 15min, add 3ml triethylamine, the reaction solution will A large amount of red precipitate appeared and was filtered. Then prepare a mixed solution of ethanol and water (the volume ratio of ethanol to water is 7:3), add the obtained yellow solid to this solution, stir at a temperature of 80°C until it is completely dissolved, then cool at room temperature, and filter to obtain The red flaky crystals are the desired product Fe(acac) 3 .

Embodiment 2

[0032] Example 2: Preparation of Amphiphilic Superparamagnetic Magnetic Resonance Contrast Agent

[0033] Add iron triacetylacetonate and platinum diacetylacetonate with a molar ratio of 2:1 into the polyol, and control the molar concentration of iron triacetylacetonate in the polyol to be 0.04mol / L; Heat the reaction system under protection. When the temperature rises to 100°C, keep it warm for 1 hour; add 5ml of oleic acid, and then continue to heat up. When the temperature rises to 200°C, keep it warm for 1 hour; When the temperature reaches 245°C, keep the reaction for 1 hour; after the reaction is completed, cool naturally to room temperature, centrifuge, wash the precipitate with absolute ethanol, and dry it in vacuum at 15°C for 10 hours to obtain fcc with polyol molecules and oleic acid molecules on the surface. type FePt nanoparticles, that is, the amphiphilic superparamagnetic magnetic resonance contrast agent with fcc type FePt nanoparticles as the core.

Embodiment 3

[0034] Example 3: Preparation of Amphiphilic Superparamagnetic Magnetic Resonance Contrast Agent

[0035] Add iron triacetylacetonate and platinum diacetylacetonate with a molar ratio of 2:1 into the polyol, and control the molar concentration of iron triacetylacetonate in the polyol to be 0.2mol / L; Heat the reaction system under protection. When the temperature rises to 140°C, keep it warm for 3 hours; add 5ml of oleic acid, and then continue to heat up. When the temperature rises to 220°C, keep it warm for 3 hours; When the temperature reaches 275°C, keep the reaction for 3 hours; after the reaction is completed, cool naturally to room temperature, centrifuge, wash the precipitate with absolute ethanol, and dry it in vacuum at 30°C for 20 hours to obtain fcc with polyol molecules and oleic acid molecules on the surface. type FePt nanoparticles, that is, the amphiphilic superparamagnetic magnetic resonance contrast agent with fcc type FePt nanoparticles as the core.

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Abstract

The invention discloses an amphipathic super-paramagnetic and magnetically resonant contrast agent and a method for preparing the contrast agent. In the method, tetraglycol is used as a solvent and oleic acid is used as a surfactant; ferrum acetylacetone and platinum acetylacetone serving as precursors are pyrolyzed at a high temperature under the condition of nitrogen protection so as to obtain an Fcc type FePt magnetic nano magnetically resonant material of which the appearance is spherical and an average grain diameter is 4 nm. The amphipathic super-paramagnetic and magnetically resonant contrast agent obtained by the technical scheme of the invention has high saturation magnetization and high initial susceptibility; furthermore, the amphipathic super-paramagnetic and magnetically resonant contrast agent has excellent reproducibility, very high saturation magnetization and good biocompatibility under biological conditions. The amphipathic super-paramagnetic and magnetically resonant contrast agent integrates the advantages of stability, aqueous solubility and biocompatibility, and reduces the toxicity.

Description

technical field [0001] The invention relates to a contrast agent, specifically an amphiphilic superparatropic magnetic resonance contrast agent, and a preparation method of the contrast agent. Background technique [0002] Magnetic resonance imaging contrast agent (MRI contrast agent / media is also called magnetic resonance imaging contrast agent) is a class of magnetic substances that can improve the sensitivity and specificity of MRI diagnosis, enhance signal contrast, and improve the resolution of soft tissue images. The MRI contrast agent itself does not produce a signal, but its role is to change the relaxation time of the proton system inside the tissue, in contrast to the surrounding tissue. MRI signal intensity and proton density ρ, spin-lattice relaxation time T 1 (spin-latticerelaxation time), spin-spin relaxation time T 2 (spin-spin relaxation time) and other physical and chemical parameters. But in soft tissue, the hydrogen proton density changes little, mainly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/06
Inventor 杨仕平张晶晶田启威杨红
Owner SHANGHAI NORMAL UNIVERSITY
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