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Production method of ammonium ferric citrate

A kind of technology of ferric ammonium citrate and production method, applied in directions such as carboxylate preparation, organic chemistry, etc., can solve problems such as high cost, low yield, difficult dehydration of ferric hydroxide colloid, and achieves reduction of production cost, improvement of production efficiency, The effect of simplifying the production process

Active Publication Date: 2010-05-12
郑州瑞普生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the generated ferric hydroxide is colloidal precipitation, and the washing process of sulfate and chloride ions is relatively difficult, and the ferric hydroxide colloid is not easy to dehydrate, making the production process costly and low yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The production method of ferric ammonium citrate of the present invention, it is prepared according to the following steps:

[0021] Step 1: Add accurately weighed 280g citric acid into 500mL water, and heat up to 60°C±5°C;

[0022] Step 2: Turn on the stirring, add 50g of iron powder, and slowly raise the temperature to 80±5°C;

[0023] Step 3: Keep the temperature at 80±5°C and stir the above feed solution for 4 hours;

[0024] Step 4: Use condensed water to cool down to 40±5°C, then add hydrogen peroxide (concentration: 28%) to oxidize to free of ferrous ions;

[0025] The fifth step: feed ammonia to neutralize the reaction material to pH=7, then filter to remove impurities;

[0026] Step 6: Concentrate the filtrate into a paste and dry it in an oven at 80°C to obtain the product ferric ammonium citrate.

Embodiment 2

[0028] The production technique of ferric ammonium citrate of the present invention, it is processed according to the following method:

[0029] Step 1: Add accurately weighed 260g of citric acid into 500mL of water, and heat up to 60°C±5°C;

[0030] Step 2: Turn on the stirring, add 40g of iron powder, and slowly raise the temperature to 80±5°C;

[0031] Step 3: Keep the temperature at 80±5°C and stir the above feed solution for 3 hours;

[0032] Step 4: Use condensed water to cool down to 40±5°C, then add hydrogen peroxide (concentration: 28%) to oxidize until there is no ferrous ion;

[0033] The fifth step: feed ammonia gas to neutralize the reaction material to pH=8, then filter to remove impurities;

[0034] Step 6: Concentrate the filtrate into a paste and put it in an oven for drying at a temperature of 70°C to obtain the product ferric ammonium citrate.

Embodiment 3

[0036] The production method of ferric ammonium citrate of the present invention, it is prepared according to the following steps:

[0037] Step 1: Add accurately weighed 300g citric acid into 500mL water, and heat up to 60°C±5°C;

[0038] Step 2: Turn on the stirring, add 60g of iron powder, and slowly raise the temperature to 80±5°C;

[0039] Step 3: Keep the temperature at 80±5°C and stir the above feed solution for 6 hours;

[0040] Step 4: Use condensed water to cool down to 40±5°C, then add hydrogen peroxide (concentration: 28%) to oxidize to free of ferrous ions;

[0041] The fifth step: feed ammonia gas to neutralize the reaction material to pH=9, then filter to remove impurities;

[0042] Step 6: Concentrate the filtrate into a paste and dry it in an oven at a temperature of 50°C to obtain the product ferric ammonium citrate.

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PUM

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Abstract

The invention discloses a production method of ammonium ferric citrate. The ammonium ferric citrate is prepared by water, citric acid and iron powder according to the following steps: 1. placing water and citric acid into a stirring device to be heated to 60 DEG C; 2. opening the stirring device, adding the iron powder, slowly heating to 80 DEG C, keeping the temperature, stirring and reacting to generate ferrous citrate; 3. cooling the ferrous citrate obtain in step 2 to 40 DEG C, adding hydrogen peroxide for oxidizing until no ferrousion exists; 4. introducing ammonia to neutralize the ferrate compound obtained in step 3 to the pH value more than or equal to 7, filtering, removing impurities and concentrating to be in a pasty shape; and 5. placing the concentrated matter obtained in step 2 into an oven for drying at the temperature of 80 DEG C. The invention has the advantages of adopting the iron powder to replace ferrous sulphate, using the hydrogen peroxide as oxidant and adopting scientific proportioning and production process, thus avoiding chloridion and sulfate ion and other impurities from being carried in, preventing from generating ferric hydroxide intermediate products which are difficult to dehydrate and wash, greatly simplifying production processes, reducing production cost and improving production efficiency of the ammonium ferric citrate.

Description

technical field [0001] The present invention relates to ferric ammonium citrate, in particular to a production method of ferric ammonium citrate. Background technique [0002] Ferric ammonium citrate, also known as ferric ammonium citrate, is a compound salt of ferric citrate and ammonium citrate. Water, insoluble in ethanol, ether and other organic solvents, the aqueous solution is neutral. Ferric ammonium citrate is widely used in medicine, food, feed, and industry. It is a good nutritional enhancer and can be used as a blood tonic to treat iron-deficiency anemia; Reducibility, it can be used for meteorological analysis and making blueprints; Ferric ammonium citrate is also an important component of some nutrient media. In addition, using ferric citrate as a raw material can improve the performance of some anticancer drugs. [0003] The current method for producing ferric ammonium citrate is to use oxidant and ammonia to make ferrous sulfate precipitate ferric hydroxide,...

Claims

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Application Information

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IPC IPC(8): C07C59/265C07C51/41
Inventor 梅志恒孙彦军
Owner 郑州瑞普生物工程有限公司
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