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Nanometer silicon dioxide particle for marking radionuclide 125I and preparation method thereof

A nano-silica, radionuclide technology, applied in the direction of silica, silicon oxide, radioactive carrier, etc., to achieve the effect of strong penetrating power, easy control and processing

Inactive Publication Date: 2012-01-25
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But with regard to labeling radionuclides 125 The nano-silica particles of I have not been reported yet.

Method used

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  • Nanometer silicon dioxide particle for marking radionuclide 125I and preparation method thereof
  • Nanometer silicon dioxide particle for marking radionuclide 125I and preparation method thereof
  • Nanometer silicon dioxide particle for marking radionuclide 125I and preparation method thereof

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Effect test

Embodiment 1

[0036] a labeled radionuclide 125 The preparation method of nano-silica particles of I, the silane amination of nano-silica particles

[0037] The nano-silica particles were placed in 0.01mol / L hydrochloric acid aqueous solution containing 50% ethanol, ultrasonicated at a frequency of 40KHz for 30min, washed repeatedly with absolute ethanol, and then set aside. In 90mL ethanol solvent, add 10mL aminopropyltriethoxysilane (molecular formula: (CH 3 CH 2 O) 3 SiCH 2 CH 2 CH 2 NH 2 ) diluted solution (coupling agent: ethanol = 1:5, V / V), dropwise added oxalic acid to make the pH of the solution 3-4, and continued to stir and hydrolyze for 1 h at room temperature. Add 200 mg of nano-silica particles into the hydrolysis coupling agent solution, stir and react in a water bath at 50-60°C for 6 hours, filter, wash with ethanol, and vacuum-dry to obtain amino-modified nano-silica particles.

[0038] two, 125 Preparation of I-BH markers

[0039] Dissolve 5 mg of succinimide p-hyd...

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Abstract

The invention relates to a nanometer silicon dioxide particle for marking a radionuclide 125I and a preparation method thereof. The method for preparing the nanometer silicon dioxide particle comprises the following steps of: (a) modifying the nanometer silicon dioxide particle with a silane coupling agent, (b) preparing a 125I-BH label, and (c) coupling the 125I-BH label with the modified nanometer silicon dioxide particle. The radionuclide 125I of the invention has a high chemical activity and a proper half-life period (60 days), and can be used for researching biological distribution and display in the nanometer silicon dioxide particle, so the radioactive pollution is easy to control and treat. The radionuclide 125I can emit Gamma ray, has high penetrating power, and can quantitatively and intuitively detect the in vivo biological distribution and display of the nanometer silicon dioxide particle.

Description

【Technical field】 [0001] The present invention relates to a kind of nano-silica particle of labeled radionuclide, specifically, a kind of labeled radionuclide 125 The nano silicon dioxide particle of I and preparation method thereof. 【Background technique】 [0002] Nano-silicon dioxide is an important nano-material, and it is a nano-powder material with the highest industrial production output in the world. In addition to the special properties of nanomaterials such as small size, large specific surface area, high surface activity, and strong adsorption capacity, nano-silica particles also have singular properties such as high strength, high toughness, and good stability at high temperatures, and are widely used in plastics. Engineering, biomedical engineering, fungicides, food processing, textile industry, agriculture and coatings, etc. are almost all fields involving conventional powdered silica. Utilizing the special properties of nano-silica particles, nano-silica can ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/02C01B33/12
Inventor 孙皎谢广平丁婷婷钟高仁
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE