Platelet envelope glycoprotein oligopeptide or trim/derivate thereof and application thereof

Abstract

The invention provides an oligopeptide R-G-S(p)-L-P capable of influencing platelet function or trim / derivate thereof and application of the oligopeptide R-G-S(p)-L-P or trim / derivate thereof in preventing and / or treating arterial thrombus disease and / or related disease interacted by platelet GPIbalpha and ABP. The platelet treated by the oligopeptide R-G-S(p)-L-P or trim / derivate thereof can effectively inhibit adhesion function of the platelet including ristomycin induced platelet aggregation function without influencing platelet aggregation function including ADP induced platelet aggregation function, thus inhibiting thrombopoiesis while basically maintaining the integrity of platelet functional status. The invention can be directly used for research and development of clinical anti-thrombus medicine.

Description

technical field

[0001] The present invention relates to a novel synthetic membrane-penetrating oligopeptide, its amino acid sequence and its ability to inhibit platelet function.

[0002] The present invention belongs to molecular biology and hematology. Background technique

[0003] Thromboembolic diseases, such as myocardial infarction, ischemic cerebral infarction, and venous thromboembolism, are currently one of the causes that seriously endanger human health and lead to high mortality. Prevention and treatment of thrombosis has become an important clinical practice. Prevention methods. Platelets play a very important role in the process of thrombus formation. During normal blood circulation, platelets are in a quiescent state, and at the site of vessel wall damage, especially in the high shear stress environment of blood vessels, platelets will receive Ib in the surface membrane glycoprotein (GP) Ib-IX complex. The body binds to the plasma von Willebrand factor (vWF)...

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