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Artificial tooth root with trace element selenium sustained-release function and preparation method thereof

A technology of artificial tooth roots and trace elements, applied in dental preparations, dentistry, dental implants, etc., to achieve the effect of anti-inflammatory and healthy teeth-induced osteogenesis, high bonding strength, and improved immunity of the body

Inactive Publication Date: 2012-02-22
江苏广达医材集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Technical problem: The purpose of this invention is to address the above-mentioned shortcomings of artificial tooth roots, and propose an artificial tooth root with a slow-release function of trace element selenium, and can significantly improve the ability of artificial tooth root surface to induce osteogenesis at the initial stage of implantation and its preparation method

Method used

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  • Artificial tooth root with trace element selenium sustained-release function and preparation method thereof
  • Artificial tooth root with trace element selenium sustained-release function and preparation method thereof
  • Artificial tooth root with trace element selenium sustained-release function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) First choose pure titanium to process the artificial tooth root;

[0025] (2) Hydrothermal treatment of the surface of the artificial tooth root: the artificial tooth root is polished and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 120 degrees Celsius. After 6 hours, a sodium titanate bioactive coating with a microporous structure was obtained on the surface of the artificial tooth root, and its SEM photos and XRD spectra are shown in figure 1 and figure 2 ;

[0026] (3) Centrifugal loading treatment of trace amounts of sodium selenite and BMP: fix the artificial tooth root with the sodium titanate bioactive coating with a microporous structure on the surface in a centrifugal cylinder, pour 5 × 10 -3 mol / L sodium selenite, 0.1-50 mg / L bone morphogenetic protein and 0.1 mol / L...

Embodiment 2

[0029] (1) First choose Ti6Al4V alloy to process the artificial tooth root;

[0030] (2) Hydrothermal treatment of the surface of the artificial tooth root: the artificial tooth root is polished and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 120 degrees Celsius. The time is 6 hours, and a sodium titanate bioactive coating with a microporous structure is obtained on the surface of the artificial tooth root;

[0031] (3) Centrifugal loading treatment of trace amounts of sodium selenite and BMP: fix the artificial tooth root with the sodium titanate bioactive coating with a microporous structure on the surface in a centrifugal cylinder, pour 5 × 10 -3 mol / L sodium selenite, 0.1-50 mg / L bone morphogenetic protein and 0.1 mol / L phosphate-buffered saline solution, and submerged more than twice...

Embodiment 3

[0034] (1) First choose pure titanium to process the artificial tooth root;

[0035] (2) Hydrothermal treatment of the surface of the artificial tooth root: the artificial tooth root is ground and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 150 degrees Celsius. The time is 72 hours, and a sodium titanate bioactive coating with a microporous structure is obtained on the surface of the artificial tooth root;

[0036] (3) Centrifugal loading treatment of trace amounts of sodium selenite and BMP: fix the artificial tooth root with the sodium titanate bioactive coating with a microporous structure on the surface in a centrifugal cylinder, pour 5 × 10 -3 mol / L sodium selenite, 0.1-50 mg / L bone morphogenetic protein and 0.1 mol / L phosphate-buffered saline solution, and submerge more than twice t...

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Abstract

The invention relates to a functional artificial tooth root with trace element selenium slow release and a preparation method thereof. The artificial tooth root is composed of a pure titanium or titanium alloy artificial tooth root base and a micro-sodium selenite and bone morphogenetic protein (BMP)-loaded artificial tooth root. The composition of the microporous sodium titanate surface layer. The bioactive coating of the sodium titanate layer with the microporous structure mentioned above is combined with the surface of the metal substrate, and the microporous structures of sodium titanate generated by the hydrothermal reaction between the surface of the titanium or titanium alloy substrate and the sodium hydroxide solution are alternately stacked and formed. In this way, trace amounts of sodium selenite and BMP are compounded in the microporous structure by centrifugal force and capillary action. The preparation method is as follows: firstly select pure titanium or titanium alloy to process the artificial tooth root; then use the alkaline solution hydrothermal synthesis technology to obtain a sodium titanate layer with a microporous structure on the surface of the titanium artificial tooth root; Sodium selenite and bone morphogenetic protein are loaded in the sodium layer.

Description

technical field [0001] The invention relates to a functional artificial tooth root with trace element selenium slow-release function and its preparation method, in particular to a microporous titanic acid made of pure titanium or titanium alloy artificial tooth root matrix and loaded with trace element selenium and bone morphogenetic protein An artificial tooth root composed of a sodium surface layer and a preparation method thereof belong to the technical field of artificial tooth root materials. Background technique [0002] Artificial dental implants can restore the function of missing natural permanent teeth, which allows patients with tooth loss that cannot be repaired by traditional methods to receive fundamental treatment and improve their quality of life. The commonly used artificial tooth roots are metal materials, because they are biologically inert materials, and cannot form a firm physiological combination with the gum tissue. After implantation, they often loose...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61C8/00A61K6/04
Inventor 储成林饶席浦跃朴
Owner 江苏广达医材集团有限公司
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