Calcium-containing citrate concentrated anticoagulant hemodialysis solution

Abstract

In vitro full anticoagulation is a precondition for ensuring the smooth progress of a blood purification technique. Based on research at home and abroad, for high-risk bleeding patients with dialysis indications, no ideal anticoagulation method exists currently. In recent years, citrate anticoagulation shows certain superiority, has definite anticoagulation effect, and is insusceptible in system coagulation function. From local citrate anticoagulation to citrate anticoagulation replacement fluid or dialysate, uncertain amount of calcium supplementation and other deficiencies still exist. According to ionization equilibrium, coordination equilibrium, proton equilibrium, theory of coordination valence bond and law of changeless total calcium, an assumption about a calcium-containing citrate concentrated anticoagulant hemodialysis solution is proposed, namely, to add calcium or magnesium ions to a novel citrate concentrated anticoagulant hemodialysis solution, and no exogenous calcium supplementation is needed, so that a clinical citrate anticoagulation method is further simplified so as to be better in clinical application, and a novel anticoagulation thought or method for clinical high-risk bleeding patients is tentatively explored as well.

Description

technical field [0001] In recent decades, the continuous development of blood purification technology has not only saved the lives of many patients with acute renal failure, but also improved the quality of life of patients with chronic renal failure, and at the same time provided a therapeutic platform for the rescue of clinical multiple organ failure. Involved in all clinical fields. [0002] Adequate anticoagulation in vitro is a prerequisite for ensuring the smooth progress of blood purification technology. Without anticoagulant, the blood in the dialyzer and dialysis circuit will activate the endogenous or exogenous coagulation system due to bioincompatibility, which will lead to coagulation, shorten the life of the filter, increase the waste of blood of the patient, and cause dialysis failure , and bring many adverse effects to patients. At present, heparin is the main anticoagulant for clinical extracorporeal circulation, but it can inhibit platelet aggregation, inhib...

AI Technical Summary

Problems solved by technology

The new citrate concentrated anticoagulant hemodialysis solution developed by Gui Baosong et al. by adding citrate as a base to the dialysate has shown certain advantages through animal experiments and clinical applications, but the amount of calcium supplementation is relatively large and the supplement The amount of calcium cannot be accurately determined and directly affects the anticoagulant effect and safety