Preparation technology for water-soluble resveratrol particle, and product and application thereof

A technology of resveratrol and preparation process, which is applied to the preparation process of water-soluble resveratrol granules and their products and application fields, can solve the problems of low bioavailability in industrial applications and the like, and achieves improved bioavailability and solubility. , the effect of improving solubility

Inactive Publication Date: 2010-06-30
TIANJIN GUONA TECH DEV CO LTD
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  • Abstract
  • Description
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Problems solved by technology

[0005] The purpose of the present invention is to develop a preparation process of water-soluble resveratrol particles and its products and applications. It aims at the problem that resveratrol is insoluble in water and has low bioavailability and is not suitable for industrial application. Resveratrol particles dissolved in water at a very high concentration solve the problem that resveratrol is difficult to dissolve in water. At the same time, the particles reach about 100nm, which speeds up the dissolution rate, greatly improves the bioavailability, and expands the resveratrol. Application range of retrol

Method used

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  • Preparation technology for water-soluble resveratrol particle, and product and application thereof
  • Preparation technology for water-soluble resveratrol particle, and product and application thereof
  • Preparation technology for water-soluble resveratrol particle, and product and application thereof

Examples

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Effect test

Embodiment 1

[0019] Embodiment 1: a kind of water-soluble resveratrol particle, its preparation method is as follows:

[0020] (1) Dissolve 0.26 g of resveratrol in 20 ml of absolute ethanol, add a small amount of stabilizer, and ultrasonically oscillate to dissolve into a light khaki transparent solution to obtain a drug sample solution;

[0021] (2) Install the supercritical fluid crystallization equipment and install a 1500um nozzle, set the supercritical fluid system, the pressure of the crystallization kettle is 120bar, the temperature is 35°C, and the flow rate is 10g / min. After the equipment is running stably, pass the high-efficiency liquid at 0.5ml / min The phase pump is pumped into the supercritical system at a constant speed. After the sample injection is completed, the residual liquid in the pipeline is washed with absolute ethanol, and the 2 After flushing with fluid for 20 minutes, adjust the pressure to atmospheric pressure, and naturally cool down to room temperature, and th...

Embodiment 2

[0024] Embodiment 2: a kind of water-soluble resveratrol particle, its preparation method is as follows:

[0025] (1) Dissolving 0.20 g of resveratrol in 20 ml of methanol, adding a small amount of stabilizer, ultrasonically oscillating and dissolving into a light khaki transparent solution to obtain a drug sample liquid;

[0026] (2) Install the supercritical fluid crystallization equipment and install a 1500um nozzle, set the supercritical fluid system, the pressure of the crystallization kettle is 120bar, the temperature is 41°C, and the flow rate is 15g / min. After the equipment is running stably, pass the high-efficiency liquid at 0.5ml / min The phase pump is pumped into the supercritical system at a constant speed. After the sample injection is completed, the residual liquid in the pipeline is washed with absolute ethanol, and the 2 After flushing with fluid for 20 minutes, adjust the pressure to atmospheric pressure, and naturally cool down to room temperature, and the ob...

Embodiment 3

[0029] Embodiment 3: a kind of water-soluble resveratrol particle, its preparation method is as follows:

[0030] (1) Dissolve 0.26 g of resveratrol in 20 ml of acetone, add a small amount of stabilizer, and ultrasonically oscillate to dissolve into a light khaki transparent solution to obtain a drug sample liquid;

[0031] (2) Install the supercritical fluid crystallization equipment and install a 400um nozzle, set the supercritical fluid system, the pressure of the crystallization kettle is 150bar, the temperature is 38°C, and the flow rate is 30g / min. After the equipment is running stably, pass the high-efficiency liquid at 0.5ml / min The phase pump is pumped into the supercritical system at a constant speed. After the sample injection is completed, the residual liquid in the pipeline is washed with absolute ethanol, and the 2 After flushing with fluid for 20 minutes, adjust the pressure to atmospheric pressure, and naturally cool down to room temperature, and the obtained p...

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Abstract

The invention relates to a preparation technology for water-soluble resveratrol particles. The preparation technology is that: (1) resveratrol transparent solution is prepared; (2) the prepared resveratrol transparent solution is pumped to the crystallizing kettle of a supercritical fluid crystallizing device; (3) residual chemical solution in a pipeline is flushed after chemical solution is fed; and (4) a pump is shut down, pressure and temperature are regulated to the natural state and the obtained particles are water-soluble resveratrol particles. The diameter of the water-soluble resveratrol particles is 50nm-200nm. X-ray diffraction shows that the particles are in the indefinite state. The water-soluble resveratrol particles can be used in medicines, healthcare foods, feeds, food additives, cosmetics and the chemical field. The invention has the advantages that the nature of indissoluble resveratrol is changed, the water solubility of the resveratrol is obviously improved and the dissolution speed in water is very fast; and since the resveratrol is rapidly precipitated in the supercritical fluid, the finished product is enabled to be loose and the dissolution speed in water is very fast.

Description

(1) Technical field: [0001] The invention relates to a development technology in the technical field of particle compatibilization of traditional Chinese medicine monomers, in particular to a preparation process of water-soluble resveratrol particles and its products and applications. (two) background technology: [0002] Resveratrol is the main raw material in medicine, chemical industry, food, and cosmetics. preventive effect etc. [0003] However, the water solubility of resveratrol is very poor, almost insoluble in water, and its low bioavailability seriously affects its wide application in various fields. Therefore, it is of great economic and clinical significance to find and develop water-soluble resveratrol particles, improve its solubility in water, increase its bioavailability, and expand its application range. [0004] For insoluble drugs, the particle size has a great influence on solubility. According to the Ostwald-Freundich equation, when the particles of in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C39/21C07C37/68A61K31/05A23L1/30A23L33/10
CPCY02P20/54
Inventor 郭震张俊魏海郑洪浩
Owner TIANJIN GUONA TECH DEV CO LTD
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