Novel chalcone compound and preparation method and application thereof

A technology for chalcone and compound, which is applied in the field of chalcone compound and its preparation, can solve the problems of lack of scientific basis for clinical drug use, complex chemical composition of Pseudomonas falciparum, difficulty in formulating quality standards, etc., and achieves reasonable design of process route. , Single ingredient, strong inhibitory effect
CN101759544AInactive Publication Date: 2010-06-30NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Publication Date
2010-06-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses novel a chalcone compound extracted and purified from Oxytropis falcate, a preparation method and an application thereof. Identified through a spectral method, the novel chalcone compound has the structural formula C15H1203 and is named 2', 4'-dihydroxy chalcone, and the preparation method combines column chromatography and preparative liquid purification method. Result from experiments in vitro shows that the novel chalcone compound can remarkably restrain the growth and proliferation of tumor cells and has good efficacy of restraining acute inflammation of mice and chronic inflammation of rats. Therefore, the novel chalcone compound is expected to be developed to be a new generation of antitumor drugs or anti-inflammatory drugs.
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Description

technical field

[0001] The invention relates to a compound, in particular to a chalcone compound, a preparation method thereof and an application thereof. Background technique

[0002] Oxytropis falcatae is the dry whole herb of Oxyptropis falcatae Bunge, a leguminous plant. The Tibetan medicine name is "E Daxia", which is recorded in the 1977 edition of "Chinese Pharmacopoeia". This medicine is widely used clinically by Tibetan medicine. It is the main drug of various Tibetan medicine compound prescriptions such as Liuwei Sickle-shaped Jidou Powder and Qizheng Xiaotong Plaster. It is a national medicine with research and development value.

[0003] In recent years, domestic scholars have carried out research on the chemical composition of this medicinal material, and isolated a variety of alkaloids, saponins and flavonoids, such as condylarin, 7-hydroxydihydroflavone, quercetin, stigmasterol, carrot Glycosides and swainsonine etc. In terms of pharmacology, in 1979, Wei Qu...

Claims

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