Brominated butyl rubber plug for sterile powder for injection

A technology of brominated butyl rubber stoppers and brominated butyl rubber, which is applied to the types of packaging items, special packaging items, medical containers, etc., can solve problems such as affecting sealing performance, strict cleaning requirements, and floating chemical indicators, and achieve low Good breathability/vapority, good biological inertness, and small compression deformation

Active Publication Date: 2010-06-30
SHANDONG PHARMA GLASS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Third, poor air tightness
The macromolecules of natural rubber stoppers have high flexibility and high diffusivity for various gases, thus affecting their sealing performance
Fourth, the use of complex technology
However, i

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0040] 1. Ingredients: According to the ingredients shown in the table below

[0041] Unit(Kg)

[0042] composition

English name

Example 1

Example 2

Example 3

bromobutyl rubber

BIIR

49

49.5

50

Calcined kaolin

China Clay

43

42.5

42

stearic acid

Stearine Acid

0.4

0.45

0.5

polyethylene wax

Paraffin Wax

3

2.5

2

Zinc oxide

Ziuc oxide

2

2.5

3

Phenolic Resin

Phenolic Resine

0.8

0.75

0.7

Titanium dioxide

Titanium Oxide

1

1.5

2

carbon black

Carbon black

0.2

0.15

0.1

[0043] composition

English name

Example 1

Example 2

Example 3

magnesium oxide

Magnesium xoide

0.2

0.25

0.3

[0044] 2. Preparation process: the ingredients are selected from any one of the formulas in Examples 1-3, and prepared b...

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PUM

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Abstract

The invention relates to a brominated butyl rubber plug for sterile powder for injection, which belongs to the technical field of medical bottle plugs and is characterized in that the brominated butyl rubber plug for sterile powder for injection comprises following ingredients in parts by weight: 49 to 50 parts of brominated butyl rubber, 42 to 43 parts of calcined china clay, 0.4 to 0.5 parts ofstearic acid, 2 to 3 parts of Tissuemat E, 2 to 3 parts of zinc oxide, 0.7 to 0.8 parts of phenolic resin, 1 to 2 parts of titanium dioxide, 0.1 to 0.2 parts of soot carbon and 0.2 to 0.3 parts of magnesium oxide. The brominated butyl rubber plug of the invention can be vulcanized by using few cleaning vulcanized agents, has low quantity of auxiliary agents and impurities, and has the advantages of high air/vapor penetration resistance, chemical agent and solvent resistance, ozone resistance, weathering resistance, thermal stability, low compression deformation and good bioinert. The brominated butyl rubber plug of the invention can be widely used for subpackage of antibiotic powder-injection medicine.

Description

technical field [0001] The invention belongs to the technical field of medicinal bottle stoppers, in particular to a bromobutyl rubber stopper for sterile powder for injection. Background technique [0002] Drugs are a special commodity, and their efficacy and quality are directly related to personal health and safety. The materials and structural forms of drug packaging, especially the packaging materials that directly contact drugs, play a decisive role in ensuring the stability of drugs. Unsuitable packaging materials can cause exudation, adsorption, and even chemical reactions of active pharmaceutical ingredients, leading to drug failure and sometimes serious toxic side effects. Therefore, whether the selection of pharmaceutical packaging materials is appropriate is an important indicator for evaluating the quality of pharmaceuticals. [0003] Rubber stoppers are an important part of bottle sealing materials in pharmaceutical packaging, mainly including natural rubber a...

Claims

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Application Information

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IPC IPC(8): C08L23/28C08L61/06C08K13/02C08K5/09C08K3/22C08K3/34A61J1/00
Inventor 扈永刚张军冯加友晁祥庆
Owner SHANDONG PHARMA GLASS
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