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Zanamivir inhalation solution and application thereof

A zanamivir, solution technology, applied in the field of zanamivir inhalation solution, to achieve the effect of increasing deposition rate, large curative effect, and reducing absorption difference

Inactive Publication Date: 2010-07-14
JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the effect of surface tension, the formed mist droplets often cannot form a stable aerosol with uniform size distribution and reach the administration site.

Method used

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  • Zanamivir inhalation solution and application thereof
  • Zanamivir inhalation solution and application thereof
  • Zanamivir inhalation solution and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Preparation of zanamivir inhalation solution

[0043]

[0044] The preparation process in Example 1.1 is as follows: Accurately weigh quantitative glucose and zanamivir, add to 900g of water, stir with a mechanical stirrer (IKA RW20 digital) at 150 rpm until completely dissolved, and finally add the remaining water to 1000g

[0045] Embodiment 1.2 and embodiment 1.3 are prepared by the same process: accurately weigh the quantitative surfactant and osmotic pressure regulator, add it to 800g of water, put the liquid into a shaker, and shake it at a frequency of 45 times per minute to completely dissolved. Then add quantitative zanamivir raw material, and continue to shake at a frequency of 60 times per minute until completely dissolved. Finally the remaining water was added to make up to 1000 g.

[0046] Example 1.4 and Example 1.5 were prepared using the same process: accurately weigh the quantitative surfactant and osmotic pressure regulator, add it to 800g of wate...

Embodiment 2

[0049] Detect the ultrasonic atomization inhalation device according to the operating instructions, install the pipeline, add 90ml of cold distilled water in the water tank, and then add 10ml of the zanamivir solution of Example 1.1. Make sure the liquid level is submerged in the sound-permeable membrane at the bottom of the tank. Tighten the lid of the can, place the atomizer in the sink, and close the lid of the sink. Power on, preheating: power on and preheat for 3 minutes. Adjust the ultrasonic frequency to be 1.5MHz, and the atomization speed is 2ml / min. The atomization nozzle is connected with a micron laser particle size analyzer (SympatecHELOS, Germany), and the volume average particle diameter ( figure 1 ); Get embodiment 1.4 and 1.6 to operate in the same way, measure its volume average particle diameter respectively ( figure 2 , image 3 ). The volume average particle diameter VMD of embodiment 1.1 is 11.05 μ tm, X 90 It is 23.81 μm; the volume average particl...

Embodiment 3

[0051] Detect the ultrasonic atomization inhalation device according to the operating instructions, install the pipeline, add 90ml of cold distilled water in the water tank, and then add 10ml of the zanamivir inhalation solution of Example 1.4. Make sure the liquid level is submerged in the sound-permeable membrane at the bottom of the tank. Tighten the lid of the can, place the atomizer in the sink, and close the lid of the sink. Power on, preheating: power on and preheat for 3 minutes. Adjust the ultrasonic frequency to 1.5MHz, and the atomization speed is 2ml / min, connect the atomization nozzle to the micron-scale laser particle size analyzer (Sympatec HELOS, Germany), and the atomization nozzle is 20cm away from the laser particle size analyzer to measure the inlet. The nozzles are connected with hoses of the same diameter. Measure the volume average particle diameter ( Figure 4 ); Get embodiment 1.6 and operate in the same way, measure the volume average particle diam...

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Abstract

The invention belongs to the fields of pharmacy and influenza, and discloses a zanamivir inhalation solution and the application thereof. The zanamivir inhalation solution is prepared by being added with a certain dosage of surface active agent and osmotic pressure regulator, and comprises the components by weight percent: 0.1-10wt percent of zanamivir, 0.01-0.5wt percent of surface active agent, 0.9-8wt % of osmotic pressure regulator and balance water. The inhalation solution is beneficial to forming aerosol granules with small grain diameter by ultrasonic atomization, and prevents the zanamivir liquid drops from merging and gathering after aerosol is formed, thus effectively transmitting the medicine into the lung of a patient, and ensuring the medicine to take the best effect.

Description

technical field [0001] The invention belongs to the fields of pharmacy and influenza, and in particular relates to a zanamivir inhalation solution and an application thereof. Background technique [0002] Influenza is called influenza for short, and is an acute respiratory infectious disease caused by three types of influenza viruses, A (A), B (B), and C (C). Influenza A virus is widely distributed in humans and animals and can cause a worldwide influenza pandemic. Influenza B viruses often cause local outbreaks and do not cause a worldwide influenza pandemic. Influenza C viruses appear in scattered forms, mainly attack infants and young children, and generally do not cause epidemics. [0003] The prevalence of influenza has a certain seasonality (the prevalence in northern my country generally occurs in winter, while that in the south mostly occurs in summer and winter), and it will naturally stop after 3-4 weeks of prevalence (worldwide pandemics often occur in 2-3 weeks...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/351A61K9/08A61P31/16A61M11/00
Inventor 孟博宇许向阳
Owner JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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