Method for preparing bionic composite material with lamellar multilevel structure

A biomimetic composite material and layered technology, which is applied in the field of biomedical materials, can solve the problems of insufficient structural design and single material selection, and achieve the effects of non-degeneration, good interlayer connectivity, and light weight

Inactive Publication Date: 2010-07-28
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the single ice template method has the following disadvantages: the material selection is relatively simple, and the structural design is not fine enough
[0005] The combination of composite microsphere preparation method and ice template method to prepare layered multi-level structure biomimetic composite materials has not been reported in various literatures

Method used

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  • Method for preparing bionic composite material with lamellar multilevel structure
  • Method for preparing bionic composite material with lamellar multilevel structure
  • Method for preparing bionic composite material with lamellar multilevel structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 0.8g of PLA with a molecular weight of 10,000 and dissolve it in 12ml of acetone with a concentration of 0.067g / ml. After fully dissolving, this is solution A; take 0.2g of nano-hydroxyapatite and disperse it in 6ml of water, and ultrasonically disperse it in the form of an emulsion It is solution B; pour solution B into solution A, and stir quickly until it is uniformly dispersed to form solution C; dissolve 0.4g polyvinyl alcohol (PVA) in 200ml water, place it on a stirrer and stir at a speed of 400rpm, and wait until it is fully dissolved , this solution is D; pour C solution into the stirring D solution at a constant speed to obtain solution E; solution E continues to stir for 6 hours to volatilize the organic solvent; then use dialysis to wash away PVA and collect HA / PLA microsphere powder Put it into an Erlenmeyer flask, ultrasonically disperse it, and put it into -20°C for 12 hours to pre-freeze; after pre-freezing, put it into a freeze dryer at -50°C and fre...

Embodiment 2

[0032] Take 10g PLA with a molecular weight of 60,000 and dissolve it in 100ml of dichloromethane with a concentration of 0.1g / ml. After fully dissolving, this is solution A; take 5gn-HA and disperse it in 20ml of dichloromethane, and disperse it ultrasonically. Solution B; pour solution B into solution A, and stir quickly until it is evenly dispersed to form solution C; dissolve 0.5% PVA in 1000ml water, place it on a stirrer and stir at a speed of 400rpm, and wait until it is fully dissolved. A beaker, this solution is D; slowly and uniformly add the C solution dropwise to the stirring D solution to obtain the solution E; continue to stir the solution E for 8 hours to evaporate the organic solvent; then use suction filtration to wash away the PVA and collect HA / PLA microsphere powder is placed in a conical flask, ultrasonically dispersed, and pre-frozen at -80°C for 12 hours; after pre-freezing, put it into a freeze dryer and freeze-dry it at -50°C, less than 20Pa for 24 hou...

Embodiment 3

[0036] Take 1.5g of PCL with a molecular weight of 100,000 and dissolve it in 22.5ml of dichloromethane with a concentration of 6.67g / ml until it is fully dissolved. This is solution A; take 1g of β-TCP and disperse it in 20ml of ethanol, and disperse it ultrasonically to form a solution in the form of an emulsion B; Pour solution B into solution A, and stir quickly until it is uniformly dispersed to form solution C; dissolve 0.5% PVA in 400ml water, place it on a stirrer and stir at a speed of 400rpm, until it is fully dissolved, divide it into four beaker, this solution is D; slowly and uniformly add solution C to the stirring solution D to obtain solution E; continue to stir solution E for 8 hours to evaporate the organic solvent; then use suction filtration to wash away PVA and collect HA / Put the PCL microsphere powder into the Erlenmeyer flask, ultrasonically disperse it, put it into -80 ℃ pre-freeze for 12 hours; after pre-freezing, put it into the freeze dryer and freez...

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Abstract

The invention discloses a method for preparing a bionic composite material with lamellar multilevel structure, belonging to the field of biomedical materials. Combining icy template method with composite microsphere method, the method prepares the bionic composite material with lamellar multilevel structure. The method not only includes economical advantage and environmental friendliness simultaneously, but can also be conducted under lasting low-temperature conditions, thus the denaturation of bioactive materials is hardly caused and the prepared composite material, having fine structure, high strength, light weight and good selectivity, is better advantageous for cell adhesion, furthermore, the composite material has excellent biocompatibility, regular array of laminas, good inter-lamina communication and bridging of similar mineral bridges. The microspheres in regular shape on the laminas are evenly embedded in lamellar organic matters, or partial microspheres are stringed around the laminas by taking threadlike organic matters as axis to form sugarcoated haws-like shape; concaves and convexes as well as extremely large surface area provided by the microspheres on the laminas of the material can create good adhesion and proliferation conditions for the growth of histiocyte and blood vessel.

Description

technical field [0001] The invention belongs to the field of biomedical materials. Background technique [0002] The hard tissue of natural organisms has a hierarchical structure from micro to macro, how to achieve hierarchical biomimetic manufacturing from micro to macro on the basis of component simulation is a major challenge in the design and manufacture of tissue engineering scaffold materials . The highly biomimetic hard tissue repair scaffold with layered porous structure is made of biomimetic composite materials with layered multi-level structure. The scaffold will provide a suitable space and microenvironment for the growth of cells, which is conducive to the construction of tissue engineering with a complete three-dimensional structure. The scaffold is repaired, and the layered structure can provide good mechanical properties for the scaffold material. Recent research results show that layered composite materials also have great application potential in adsorptio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46
Inventor 张胜民杨建霞周磊
Owner HUAZHONG UNIV OF SCI & TECH
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