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Adhering troches with topically active ingredients for treatment of throat, esophagus, and stomach

A technology of adhesion and lozenges, applied in the direction of medical preparations containing active ingredients, gene therapy, genetic material components, etc.

Inactive Publication Date: 2010-08-11
ORAHEALTH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because there is no delivery of the drug over time, the drug may be taken at a time of day before the problem typically manifests

Method used

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  • Adhering troches with topically active ingredients for treatment of throat, esophagus, and stomach
  • Adhering troches with topically active ingredients for treatment of throat, esophagus, and stomach
  • Adhering troches with topically active ingredients for treatment of throat, esophagus, and stomach

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Embodiment Construction

[0023] The present inventors have discovered that time-released collagen and licorice extract adhesive lozenges prepared by the methods taught in U.S. Patent No. 7,201,930 and U.S. Patent Application No. 11 / 157,054 (both of which are incorporated herein by reference) When administered at the initial stage of viral infection where the first symptom is a sore throat, it will be effective against sore throat and prevent the aggravation of sore throat (pharynx). In order to provide sufficient levels of collagen to effectively coat the throat, lozenges must have at least 25% collagen, such as collagen from gelatin.

[0024] Antacids use different combinations of four basic salts -- sodium, magnesium, calcium, and aluminum -- in hydroxide, carbonate, bicarbonate, or similar ions to neutralize acid in the stomach. However, antacids can have side effects. Magnesium salts can cause diarrhea and aluminum salts can cause constipation. Aluminum and magnesium salts are often combined in ...

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Abstract

A method for combating unwanted conditions downstream of the mouth with adhering troches. A method to treat or reduce replication of a virus in throat tissues by releasing an anti-viral from an adhering disc. A method to treat sore throat with time release of Glycyrrhiza extract or collagen from an adhering disc. A method to treat sore throat with topically applied cobalamin. An adhering troche that releases antacid, alginate, bismuth subsalicylate, soluble zinc, such as zinc gluconate, bioactive vitamin B12 (methylcobalamin), antibiotic, or anti-viral. A method to combat bacterial effects downstream of the mouth with topically applied xylitol.

Description

Background of the invention [0001] Disorders of the throat, esophagus and stomach have long been treated using topically active ingredients swallowed as a liquid or chewed and swallowed as a slurry. In each case, the topical treatment was short-lived as the liquid or slurry glides on. These materials don't even stay long in the stomach, which sends them to the duodenum. Items swallowed into the stomach do not linger except when the material is food in process, which in turn dilutes any topical medication. For this reason, drugs that act locally on the throat, esophagus or stomach must be taken frequently to remain effective. [0002] "Peptic ulcer disease" includes ulcers in the upper gastrointestinal tract, esophagus, stomach and duodenum of various causes, mostly infections caused by Helicobacter pylori. Topical medications used for treatment include: (1) mucosal protectants, such as alginates, that protect the gastric mucosa from acid damage Sucralfate ( or ) and m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K9/20A61K9/14A61K48/00A61K9/22
CPCA61K36/484A61K9/006A61K9/2086A61K9/0056
Inventor 杰弗瑞·T·黑利
Owner ORAHEALTH CORP
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