Rapid transdermal delivery system of local anesthetics

Abstract

The invention belongs to the technical field of transdermal delivery, in particular to a rapid transdermal delivery system of local anesthetics, which directly uses a preparation that is loaded with the local anesthetic, characterized by nano-materials and can control the release for transdermal delivery, or adds the preparation into thermo-sensitive gel poloxamer F127 solution with the concentration of 5%-40%, prepares a gel or a cream by regulating the temperature and directly uses the gel or the cream for transdermal delivery, or realizes the rapid transdermal delivery through pretreatment or an ultrasonic transmission device and / or an iontophoresis device treating the skin simultaneously under the common action of ultrasonic introduction, iontophoresis introduction or the combination of the two methods. The rapid transdermal delivery system can lead the transdermal permeation amount, the anesthetic onset time and the anesthetic potency of the local anesthetics, such as lidocaine, tetracaine, prilocaine, bupivacaine, ropivacaine, dicaine and the like to be better than those of the ordinary surface anesthetic preparation, solve the defects of long onset time of the existing surface anesthetic and limited action effects, eliminate the obvious skin irritation and be used for symptomatic treatment of skin anesthesia and neuropathic pain with skin invasive operation.

Description

Technical field:

[0001] The invention belongs to the technical field of transdermal administration, in particular to a rapid transdermal administration system for local anesthetics. Background technique:

[0002] Transdermal drug delivery technology is a drug delivery method that actively or passively penetrates the drug from the outside of the intact skin to the subcutaneous tissue. Due to the barrier function of the skin, especially the stratum corneum of the skin, it takes a long time for the drug to enter the subcutaneous tissue, and the amount of entry is also relatively limited. Transdermal administration of local anesthetics is mainly used in invasive skin operations, such as catheter placement, skin surgery and other skin surface anesthesia, and the treatment of neuropathic pain, such as post-herpetic pain. At present, the onset time of related products is still long, and it is difficult to achieve a satisfactory anesthesia effect in a short period of time, so the c...

Images