Preparation process of D-mannose

A preparation process and mannose technology, which are applied in the field of six-carbon sugar preparation technology, can solve the problems of high purchase cost, low yield and purity, and high cost of fructose, and achieve full utilization, product purity improvement, and product yield improvement. Effect

Active Publication Date: 2010-10-06
石家庄华旭药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this preparation process, due to the difficulty in separating mannose and fructose, the purity of crystalline D-mannose is difficult to reach more than 99% under the condition of a yield of more than 20%.
Moreover, in industrial production, more than 85% of high fructose syrup is made from glucose isomerization, resulting in the purchase cost of fructose being higher than that of glucose
Therefore, the preparation process of this patent is not only costly but also difficult to separate the finished product, resulting in low yield and purity of the product, which is not suitable for industrial production

Method used

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  • Preparation process of D-mannose
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  • Preparation process of D-mannose

Examples

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Effect test

Embodiment 1

[0035] Dilute 5Kg of crystalline glucose with purified water to a concentration of 45%, add 15g of catalyst molybdate, and carry out epimerization under vacuum at 90°C. The mannose content in the obtained isomerized mixture is 29.2%. After desalting and refining the above-mentioned heterogeneous mixture, it enters a simulated moving bed for separation and purification to obtain mannose-rich component B1 and glucose-rich component A1. Component A1 is returned to the simulated moving bed system for recycling, and the content of mannose in component B1 is 93.2%. Component B1 was evaporated once to a concentration of 55%, and then 14 g of activated carbon was added for decolorization. After decolorization, it was evaporated twice to obtain a feed solution with a concentration of 90%. The feed solution was subjected to aqueous phase crystallization. Gradient temperature control during the crystallization process: 0-12 hours, drop 0.5°C per hour; 13-24 hours, drop 0.8°C per hour; a...

Embodiment 2

[0037]Dilute 5Kg of crystalline glucose with purified water to a concentration of 50%, add 13g of catalyst molybdate, and carry out epimerization under a vacuum condition of 95°C. The content of mannose in the obtained isomerized mixture is 28.5%. After desalting and refining the above-mentioned heterogeneous mixture, it enters a simulated moving bed for separation and purification to obtain mannose-rich component B1 and glucose-rich component A1. Component A1 is returned to the simulated moving bed system for recycling, and the content of mannose in component B1 is 90.6%. Component B1 was evaporated once to a concentration of 60%, and then 15 g of activated carbon was added for decolorization. After decolorization, it was evaporated twice to obtain a feed solution with a concentration of 91%. The feed solution was subjected to aqueous phase crystallization. Gradient temperature control during the crystallization process: 0-12 hours, drop 0.5°C per hour; 13-24 hours, drop 0.8...

Embodiment 3

[0039] Dilute 5Kg of crystalline glucose with purified water to a concentration of 50%, add 14g of catalyst molybdate, and carry out epimerization under a vacuum condition of 100°C. The content of mannose in the obtained isomerized mixture is 29.2%. After desalting and refining the above-mentioned heterogeneous mixture, it enters a simulated moving bed for separation and purification to obtain mannose-rich component B1 and glucose-rich component A1. Component A1 is returned to the simulated moving bed system for recycling, and the content of mannose in component B1 is 91.2%. Component B1 was evaporated once to a concentration of 55%, and then 18 g of activated carbon was added for decolorization. After decolorization, it was evaporated twice to obtain a feed solution with a concentration of 92%. The feed solution was subjected to aqueous phase crystallization. Gradient temperature control during the crystallization process: 0-12 hours, drop 0.5°C per hour; 13-24 hours, drop 0...

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Abstract

The invention discloses a preparation process of D-mannose, which comprises the following steps that: glucose takes molybdate as a catalyst to be epimerized and converted into mannose under acidic conditions; through simulating the separation of a moving bed, a mannose-rich component B1 and a glucose-rich composition A1 are obtained; the glucose-rich component A1 returns to be epimerized; the mannose-rich component B1 is concentrated; the feed liquid is crystallized in an aqueous phase and centrifuged to obtain crystalline D-mannose C1and mannose mother liquor D1; and the crystalline D-mannose C1 is soaked in absolute ethyl alcohol, refined and dried to obtain a high-purity crystalline D-mannose finished product. The invention has simple process, low environmental pollution degree, low production cost and high purity of products.

Description

technical field [0001] The invention relates to a process for preparing six-carbon sugar, in particular to a process for preparing D-mannose. Background technique [0002] D-Mannose is a white crystalline powder with a sweet and bitter taste. Soluble in water, slightly soluble in ethanol. As a six-carbon sugar, D-mannose rarely exists in free form in nature, and mostly exists in the form of mannan. Mannose can be used as an additive for food and beverages, and it is also used in the field of medicine. It has a good auxiliary therapeutic effect on patients with diabetes, obesity, constipation and high cholesterol. In addition, mannose, as the most important of the eight major glyconutrients, helps intercellular communication, inhibits tumor growth, and prevents parasites, bacteria, viruses and bacterial infections. In terms of anti-inflammation, it can reduce the symptoms of rheumatoid arthritis and inhibit the inflammatory response during wound healing. [0003] The indu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C13K13/00
Inventor 谭卫星洪顺义刘彦卿苏同芳容淑祥容文谦
Owner 石家庄华旭药业有限责任公司
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