Hepatitis B virus affinity adsorption column and preparation method thereof

A hepatitis B virus and adsorption column technology, applied in the direction of selective adsorption, ion exchange regeneration, ion exchange, etc., can solve the problems of hepatitis B virus easy to mutate, fail to achieve therapeutic effect, affect therapeutic effect, etc., and achieve remarkable therapeutic effect , significant curative effect, good blood compatibility

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  • Abstract
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  • Application Information

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Problems solved by technology

[0004] The current antiviral therapy for the treatment of hepatitis B has high cost, long course of treatment, and large side effects, and cannot achieve a good therapeutic effect. Economic pressure and psychological burden

Method used

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  • Hepatitis B virus affinity adsorption column and preparation method thereof
  • Hepatitis B virus affinity adsorption column and preparation method thereof
  • Hepatitis B virus affinity adsorption column and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0036] Below in conjunction with accompanying drawing and embodiment describe in detail:

[0037] One, a kind of hepatitis B virus affinity adsorption column (abbreviation adsorption column)

[0038] 1. Overall

[0039] Such as figure 1 , the adsorption column includes an affinity microsphere 1, a polyester column 2 and a separation membrane;

[0040] Affinity microspheres 1 are loaded into the polyester column 2, and the two ends of the polyester column 2 are closed by separation membranes 3.

[0041] 2. Function block

[0042] 1) Affinity Microsphere 1

[0043] Using chitosan with a molecular weight of 100,000 to make dark brown spherical particles with a diameter of 60-150 μm to obtain an adsorption microsphere;

[0044] Adding an activator to the adsorption microspheres to obtain activated microspheres;

[0045] Adding hepatitis B human immunoglobulin to the activated microspheres for antibody immobilization to obtain affinity microspheres.

[0046] The present inve...

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Abstract

The invention discloses a hepatitis B virus affinity adsorption column and a preparation method thereof, and relates to blood perfusion technology. The adsorption column comprises affinity microspheres (1), a polyester column (2) and separation membranes (3), wherein the polyester column (2) is filled with the affinity microspheres (1); and the two ends of the polyester column (2) are sealed by using the separation membranes (3). The method comprises the following steps of: (1) preparing adsorption microspheres; (2) activating the adsorption microspheres to obtain activated microspheres; (3) fixing an anti-body to obtain the affinity microspheres; (4) sealing unreacted aldehyde groups and epoxy groups; (5) filling the column; and (6) sealing membranes. The hepatitis B virus affinity adsorption column can assist or replace antiretroviral therapy of hepatitis B, has a remarkable effect, is suitable for clearing hepatitis B virus in the blood of a hepatitis B virus carrier, a patient with chronic hepatitis B, a patient with severe hepatitis B and a patient with liver cancer, and fulfills the aims of remission, treatment and saving the lives of patients.

Description

technical field [0001] The invention relates to a hemoperfusion technology, in particular to a hepatitis B virus affinity adsorption column and a preparation method thereof. Background technique [0002] Blood purification techniques include hemodialysis, hemofiltration, hemodiafiltration, hemoperfusion, plasma separation and therapeutic separation, and blood component adsorption therapy. Since 1979, Terman first reported the use of DNA immunoadsorption column and hemoperfusion technology to treat systemic lupus erythematosus (SLE), which has entered a new stage of immunoadsorption therapy for immune diseases. In recent years, blood purification technology has attracted more and more attention in the in vitro treatment of diseases, and people continue to open up new fields of blood purification technology in the treatment of difficult diseases. [0003] Hepatitis B is a common viral infectious disease that plagues people at present, and it is very popular in my country. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/38B01D15/08
Inventor 王业富李慧
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