Composition with disintoxicating and liver-protecting effects and application thereof in food and health-care food

A technology for anti-alcoholic and liver-protecting and health food, which is applied in the application field of composition, food and health food with anti-alcoholic and liver-protecting effects, and can solve problems such as insignificant anti-alcoholic effect, unsuitable eating habits, and large body side effects , to prevent and improve excessive drinking, reduce ethanol concentration and active oxygen concentration, and reduce liver damage

Active Publication Date: 2012-09-26
SHANDONG MINGREN FURUIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Looking at the anti-alcoholic products currently on the market, most of them stimulate vomiting and urge the excretion of alcohol in the stomach; the other type is drugs for nourishing the stomach and protecting the liver, which have no direct and obvious effect on acute alcoholism; Some hangover teas and oral liquids are mainly made of pharmaceutical chemicals or traditional Chinese medicines. The taste of the medicine is too strong. Long-term use will cause serious side effects on the body, but the effect on hangover is not significant; It does not conform to the traditional Chinese eating habits

Method used

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  • Composition with disintoxicating and liver-protecting effects and application thereof in food and health-care food
  • Composition with disintoxicating and liver-protecting effects and application thereof in food and health-care food
  • Composition with disintoxicating and liver-protecting effects and application thereof in food and health-care food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 composition chewable tablet of the present invention

[0026] 1. Formula

[0027] Curcumin 29.02g

[0028] Zinc Lactate 7.42g

[0029] Glutamine 480g

[0030] Alanine 480g

[0031] Xylooligosaccharides 375g

[0032] Citric acid 8.37 grams

[0033] Menthol 1.48g

[0034] Peppermint oil 0.20ml

[0035] 2. Granulation and tableting

[0036] Mix curcumin, glutamine, and alanine as a base material, and dissolve xylooligosaccharides, zinc lactate, and citric acid in an equal amount of purified water as a binder, and then granulate in one step. Dissolve menthol and peppermint oil in 75% ethanol, spray into the granules at room temperature, mix well, granulate, pass through a 20-mesh sieve, mix well, add appropriate amount of microcrystalline cellulose and magnesium stearate, mix well, and press into 1000 tablets , each weighing 1.35 grams, that is.

Embodiment 2

[0037] The preparation of embodiment 2 composition granules of the present invention

[0038] 1. Formula

[0039] Curcumin 20.15g

[0040] Zinc Lactate 5.50g

[0041]Glutamine 360g

[0042] Alanine 380g

[0043] Xylooligosaccharides 280g

[0044] 6.05 grams of citric acid

[0045] Menthol 1.10g

[0046] Peppermint oil 0.15ml

[0047] 2. Granulation

[0048] Mix curcumin, glutamine, alanine, as base material, xylooligosaccharide, zinc lactate, lemon

[0049] Acid plus an equal amount of purified water dissolved as a binder, one-step granulation. Dissolve menthol and peppermint oil in 75% ethanol

[0050] solution, sprayed into the granules at room temperature, mixed evenly, granulated, passed through a 20-mesh sieve, and made into 1000 grams of granules.

Embodiment 3

[0051] Embodiment 3 The anti-alcoholic effect of the composition of the present invention on alcohol poisoning mice

[0052] 1. Materials and methods

[0053] 1.1 Animals: healthy Kunming mice, half male and half male, weighing 24-28g

[0054] 1.2 Drugs and reagents

[0055] Complex amino acid chewable tablet (chewable tablet made from the composition of the present invention) aqueous solution: take the tablet, grind it finely, and prepare a suspension with a content of 0.25 g / ml and 0.5 g / ml with water.

[0056] 56° Red Star Erguotou Liquor: Beijing Red Star Co., Ltd.

[0057] Adenosine triphosphate: (ATP), Tween 20, iodonitrotetrazolium violet (INT), phenazine methyl sulfate (PMS), coenzyme I (NAD), alcohol dehydrogenase (ADH) standard, all are Sigma company's product.

[0058] 1.3 Experimental method

[0059] 1.3.1 The effect of prophylactic administration of compound amino acid chewable tablets on the time and rate of drunkenness in mice with acute alcoholism

[0060...

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Abstract

The invention relates to a composition with disintoxicating and liver-protecting effects, which comprises the following raw materials in percentage by mass: 0.15 to 5 percent of crucumin, 0.04 to 1.0 percent of zinc lactate, 10 to 50 percent of glutamine, 10 to 50 percent of alanine and 10 to 50 percent of xylooligosaccharide. It is proved that, by an animal experiment and a human tasting experiment, the composition increases the alcohol dehydrogenase and acetaldehyde dehydrogenase content of a body and rapidly decomposes alcohol, so that the composition has the effects of promoting alcohol metabolism in a liver and reducing the alcohol concentration and active oxygen concentration in a blood; and the composition increases an endurance capacity of a human body to the alcohol, reduces the discomforts such as headache, nausea, vomiting and the like due to the alcohol, and reduces the damages of the alcohol to the liver. The composition can be prepared into food and health-care food withthe disintoxicating and liver-protecting effects, can be used as a disintoxicating product for preventing and improving excessive drinking, and can be used as an adjuvant therapy product for an alcoholic liver, a fatty liver due to the alcohol or non-alcohol and protecting the liver; and the composition has the advantages of safety, non-toxicity and a reliable curative effect.

Description

technical field [0001] The invention relates to a composition, in particular to a composition with anti-alcoholic and liver-protecting effects and its application in food and health food. Background technique [0002] my country is a big wine culture country with a history of nearly a thousand years, and drinking has become an indispensable part of people's lives. Drinking often makes people excited, angry or happy. In severe cases, they have unsteady gait and incoherent speech, accompanied by increased blood pressure, increased heart rate, decreased blood sugar, and discomfort in the gastrointestinal tract, head and face, and limbs. Studies have shown that when drinking alcohol, alcohol enters the blood through the stomach and intestines, and is metabolized by an alcohol dehydrogenase, which converts toxic substances produced by alcohol metabolism into non-toxic acetic acid, and finally decomposes into water and carbon dioxide. However, within a certain period of time, hum...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/29A61K31/702A61K31/198A61K31/19A61K31/12A61P1/16A61P43/00A23L33/00
Inventor 凌沛学张玲尚立霞
Owner SHANDONG MINGREN FURUIDA PHARMA
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