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Topical cosmetic skin lightening compositions and methods of use thereof

A composition, topical technology, applied in the direction of cosmetics, drug combinations, skin diseases, etc.

Inactive Publication Date: 2010-12-15
STIEFEL LABORATORIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These products currently in use contain hydroquinone, but these products have been considered unacceptable for toxicological reasons

Method used

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  • Topical cosmetic skin lightening compositions and methods of use thereof
  • Topical cosmetic skin lightening compositions and methods of use thereof
  • Topical cosmetic skin lightening compositions and methods of use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0155] In one embodiment, the described topical cosmetic composition may optionally further contain at least one cosmetically acceptable excipient which may contain or include at least one antioxidant , the antioxidant may contain or include one or more selected from the following components: butylated hydroxytoluene, sodium metabisulfite, butylated hydroxyanisole, ascorbic acid and its derivatives, sulfite and its derivatives substances, esters, tocopheryl acetate, and combinations thereof; chelating agents, which may contain or include one or more selected from the group consisting of disodium edetate, EDTA, disodium EDTA, trisodium EDTA , tetrasodium EDTA, and combinations thereof; emollients, which may contain or include one or more selected from the group consisting of glycols, silicon-containing emollients, and combinations thereof; thickeners , the thickener may contain or include one or more selected from the following components: acrylate copolymer, acrylate, acrylami...

Embodiment 1

[0212] The following examples illustrate the clarifying efficacy of a topical cosmetic composition of the present invention compared to a 2% hydroquinone composition, as determined by the colorimetric instrument method.

[0213] The clarifying efficacy of each of the two topical products was evaluated in the previously hyperpigmented skin of 10 volunteers in a single center double blind comparative clinical trial lasting 6 weeks. Dermatological assessments were performed at the beginning and end of the study. Skin color was measured at T0, T07, T14 and T21 with a colorimeter and photographic documentation. UVB pigmentation was induced on the previously pigmented skin of the volunteers by using a light emission source, namely a solar simulator (solarsimulator) with Xenon arc light 601 / 300W (manufactured by Solar Light Co).

[0214] The degree of skin pigmentation was determined by the standard color system CIE (The Commission Internacional del'Eclairage) using a Minolta Chroma...

Embodiment 2

[0365] The following examples describe the preparation of emulsions according to the subject matter described in this invention:

[0366] components Features %W / W

[0367] Purified water Carrier 62.250

[0368] Cetyl Alcohol Thickener 2

[0369] Xanthan Gum Thickener 0.2

[0370] Butylated hydroxytoluene Antioxidant 0.050

[0371] C14-22 Alcohol and C12-20 Alkyl Glucoside Emulsifier 2

[0372] Potassium Cetyl Phosphate Emulsifier 1

[0373] Glyceryl Stearate and Macrogol (100) Stearate Emulsifier 2

[0374] Cyclomethicone Emollient 2

[0375] Disodium EDTA Chelating agent 0.2

[0376] Daisy Flower Extract Antioxidant / Active Agent 5

[0377] Amla Fruit Extract Antioxidant / Active Agent 2

[0378] Licorice Extract Antioxidant / Active 0.050

[0379] Phenoxyethanol and methylisothiazolinone Preservatives 0.6

[0380] Fragrance FAV22000-Essential Oil Blend Fragrance 0.3

[0381] Hydroxyethyl Acrylate, Thickener 5

[0382] Sodium Acryloyldimethyltaurate Copolymer, ...

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Abstract

Topical cosmetic compositions are provided that can comprise a Phyllanthus extract, a BeIHs extract, and a licorice (Glycyrrhiza) extract. These compositions are used for topical cosmetic applications, particularly to lighten skin. Methods for lightening skin are also provided and can comprise topically administering a therapeutically effective amount of a topical cosmetic composition comprising a Phyllanthus extract, a BeIHs extract, and a licorice extract, to skin of a subject in need thereof.

Description

technical field [0001] The subject matter described in this invention relates to topical cosmetic or dermatological compositions containing plant extracts. These compositions are useful for topical cosmetic applications, especially for the treatment of unwanted skin pigmentation. Background of the invention [0002] Melanocytes, located in the lowest layer of the epidermis (basal layer, adjacent to the basal cells), are pigment-forming cells that occur singly or in clusters depending on the skin type. Melanocytes contain melanosomes, which form melanin at a relatively rapid rate when stimulated by UV radiation. Melanin is transported into keratinocytes and more or less leads to a prominent tan and brown complexion. [0003] Melanin is the end product of an oxidation process in which tyrosine is transformed with the aid of tyrosinase through 3,4-dihydroxyphenylalanine (dopa), dopaquinone, leucodopachrome ), dopachrome, 5,6-dihydroxyindole and indole-5,6-quinone, and finall...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/06A61K9/08A61K8/02A61K8/19A61K8/67A61K8/97
CPCA61K36/484A61K8/97A61K36/47A61Q17/04A61K36/28A61K9/0014A61Q19/02A61K8/9789A61P17/16A61P43/00A61K2300/00
Inventor 乔奥·P·西塔诺莫妮卡·A·M·德奥利维拉
Owner STIEFEL LABORATORIES
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