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Process for extracting and separating Angoroside C from radix scrophulariae and novel medical application of Angoroside C

An angoloside, a technology for use, applied in the field of traditional Chinese medicine pharmaceuticals, to achieve the effect of simple extraction process, reduced incidence, and improved quality of life

Inactive Publication Date: 2011-01-12
SHANGHAI UNIV OF T C M +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are no relevant reports on the process of extracting and purifying angroside C from Scrophulariaceae by water extraction, alcohol precipitation, macroporous resin and silica gel chromatography

Method used

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  • Process for extracting and separating Angoroside C from radix scrophulariae and novel medical application of Angoroside C
  • Process for extracting and separating Angoroside C from radix scrophulariae and novel medical application of Angoroside C
  • Process for extracting and separating Angoroside C from radix scrophulariae and novel medical application of Angoroside C

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Isolation and extraction of beangaloside C from Radix Scrophulariae and identification of its structure:

[0025] Weigh 8kg Scrophulariae decoction pieces (Scrophulariaceae is the dry root of Scrophularia ningpoensis Hemsl), a perennial herb of the family Scrophulariaceae, add 10 times the weight of water and decoct 3 times, each time for 1.5 hours, combine the decoction, decompress Concentrate to a density of 1.1 to 1.3, add 3 times the volume of 95% ethanol, stir well, let it stand overnight, filter with suction, recover the ethanol from the filtrate until it has no alcohol smell, add water to the concentrated solution to make 3 liters, and extract it three times with ethyl acetate (each Use ethyl acetate 800ml for the first time), evaporate the ethyl acetate in the water layer and apply 4kgHPD100 macroporous adsorption resin, first wash away water-soluble sugar, inorganic salt and other impurities with 10 times column volume of deionized water, and then use 4 to 6 tim...

Embodiment 2

[0031] Improvement effect of angroside C on ventricular remodeling in rats induced by abdominal aorta ligation:

[0032] Rats were anesthetized by intraperitoneal injection of 3% pentobarbital sodium 0.1ml / 100g, fixed in the supine position, the abdominal cavity was opened, the abdominal aorta was bluntly separated, and the abdominal area between the left and right renal arteries was incompletely ligated with a silver clip with an inner diameter of 0.6mm. The outer diameter of the aorta was narrowed to 0.6 mm to prepare a pressure overload ventricular remodeling model. Animals in the sham operation group were only separated from the abdominal aorta without ligation. Postoperative intramuscular injection of penicillin 1×10 4 U·kg -1 d -1 , a total of 3d, to prevent infection.

[0033] Three days after modeling, the rats in the operation group were randomly divided into 10 rats in each group. Administration once a day, 20ml / kg / d, continuous administration for 4 weeks. ①Ang...

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Abstract

The invention belongs to the pharmaceutical field of traditional Chinese medicine, relating to application of phenylpropanoid component-Angoroside C in traditional Chinese medicine of radix scrophulariae to preparing a medicament for preventing and treating myocardial hypertrophy, ventricular remodeling and congestive heart failure. The function of the Angoroside C is researched by utilizing a rat ventricle reconstruction model caused by abdominal aortic coarctation. Experimental results show that the Angoroside C improves symptoms of myocardial hypertrophy and ventricular remodeling and biological functions of myocardium through inhibiting related stimulating and mediated factors resulting in myocardial hypertrophy and ventricular remodeling. The Angoroside C has obvious inhibiting effects on cardiomyocyte hypertrophy and interstitial collagen remodeling, can balance myocardial collagen fiber metabolism, can be used for preparing the medicament for preventing and treating myocardial hypertrophy and ventricular remodeling and can further prevent or delay occurrence and development of heart failure and reduce the incidence rate of arrhythmia, heart failure and sudden death of a patient suffering from myocardial hypertrophy and ventricular remodeling. Furthermore, the invention discloses a novel process for extracting and separating the Angoroside C from radix scrophulariae.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a new medical application of phenylpropanoid component-angoloside C in the traditional Chinese medicine Scrophulariaceae Scrophulariae. In addition, the present invention relates to a new process for extracting and separating angroside C from Radix Scrophulariae. Background technique [0002] Scrophulariaceae is the dried root of Scrophularia ningpoenisis Hemsl., a plant of the family Scrophulariaceae. It is a commonly used traditional Chinese medicine. It is slightly cold in nature, sweet, bitter, and salty. Pharmacological studies have shown that it has antihypertensive, antibacterial, hypoglycemic, and antipyretic effects. It is often used for fever, polydipsia, spots, gingivitis, tonsillitis, carbuncle, acute lymphoarthritis, lymphatic tuberculosis, intestinal dryness and constipation. It has been reported that Scrophulariaceae phenylpropanoid glycosides i...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61P9/00A61P9/04A61P9/06C07H15/18C07H1/08
Inventor 陈长勋宋纯清顾伟梁茅仁刚金若敏
Owner SHANGHAI UNIV OF T C M
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