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Veterinary nanometer suspension, preparation method thereof and application thereof

A nanosuspension and veterinary drug technology, applied in the directions of pharmaceutical formulations, antibacterial drugs, drug combinations, etc., can solve the problems of lack of formula, preparation method and application of veterinary drug nanosuspension, and improve the bioavailability and treatment of veterinary drugs. effect, reducing dosage, reducing the effect of organic solvents

Active Publication Date: 2011-01-19
LUOYANG RUIHUA ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the varieties of nanosuspension medicines that have been on the market for human use include paclitaxel (Abraxan), an immunosuppressant sirolimus (Rapamune), and an antiemetic drug aprepitant (Emend), etc. The preparation of drugs into nanosuspensions has not been applied, especially the lack of specific formulations, preparation methods and applications of veterinary drug nanosuspensions

Method used

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  • Veterinary nanometer suspension, preparation method thereof and application thereof
  • Veterinary nanometer suspension, preparation method thereof and application thereof
  • Veterinary nanometer suspension, preparation method thereof and application thereof

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preparation example Construction

[0034] The preparation method of the nanosuspension of the present invention uses a high-pressure homogenizer to repeat homogenization and microporous filtration, and the particle diameter obtained is less, and the particle diameter is less than 220nm, and the particle diameter range difference (the maximum particle diameter of a medicine and The minimum particle size difference) is 45-85 nm, while the ordinary suspension not treated by the method of the present invention has a larger particle size, generally 0-50 μm, and its particle size range is as high as about tens of microns. Therefore, the nanosuspension obtained by the method of the present invention has a small particle size, which is convenient for absorption by animal bodies.

[0035]Example 1 of the present invention was carried out by measuring the particle size, stability, irritation and clinical curative effect of the florfenicol nanosuspension prepared by the present invention. As a result, the nano-suspension ...

Embodiment 1

[0040] Preparation and properties of embodiment 1 Florfenicol injection nanosuspension

[0041] 1. Preparation of Florfenicol Injectable Nanosuspension

[0042] Measure the reagents and drugs according to the following proportions:

[0043] Florfenicol 30% W / V

[0044] Povidone 20% W / V

[0045] Propylene Glycol 10%W / V

[0046] Phospholipids 5%W / V

[0047] Sodium sulfite 0.2%W / V

[0048] Water for injection to 100% volume.

[0049] The specific process of preparation is:

[0050] 1) Take 300ml of water for injection, add 100g of propylene glycol, mix well, add 300g of florfenicol, stir well to obtain a mixture;

[0051] 2) Take 200ml of water for injection, add 2g of sodium sulfite, 200g of povidone, and 50g of phospholipid, and stir to obtain a mixture;

[0052] 3) Add the mixture obtained in step 2) to the mixture obtained in step 1), mix well, add water for injection to 1000ml, mix well, then repeat the homogenization through a high-pressure homogenizer for 2-3 times...

Embodiment 2

[0097] Example 2 Amoxicillin injection nanosuspension and freeze-dried powder

[0098] 1. Preparation of Amoxicillin Nanosuspension

[0099] Amoxicillin 15% W / V

[0100] Povidone 15% W / V

[0101] Propylene Glycol 8%W / V

[0102] Phospholipids 3%W / V

[0103] Sodium Thiosulfate 0.1%W / V

[0104] Water for injection to 100% volume.

[0105] The preparation method refers to Example 1 to obtain the amoxicillin nanosuspension.

[0106] 2. Preparation of Amoxicillin Nano-lyophilized Powder

[0107] Take 500ml of amoxicillin nano-suspension, add 2.5g of aspartic acid, and freeze-dry to remove the organic solvent to obtain a sterile freeze-dried solid powder of amoxicillin nanoparticles.

[0108] Amoxicillin nano-suspension and lyophilized powder were measured by laser particle size analyzer, the average particle diameters were 136.7nm and 138.2nm respectively, the particle diameter ranges were 108-153nm, 113-158nm respectively, and the particle diameter range difference was 45nm ...

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Abstract

The invention discloses the application of nanotechnology to the preparation of veterinary medicaments and also discloses a preparation method of veterinary nanometer suspension. The nanometer suspension prepared by the method has high stability and small irritation to animals. Compared with the common suspension or injection, the suspension prepared by the method uses less organic solvent, has a lower preparation cost, and can be used for preparing medicaments wildly used in the veterinary clinic.

Description

technical field [0001] The invention relates to an application of nanotechnology in the preparation of veterinary drugs, in particular to a nano-suspension of veterinary drugs and a preparation method thereof, belonging to the field of veterinary drugs. Background technique [0002] The solubility of drugs is one of the important factors affecting the bioavailability of drugs. Insoluble drugs are difficult to be absorbed by animals due to their low solubility in water, resulting in poor bioavailability. With the widespread application of combinatorial chemistry, gene screening, high-throughput screening and other technologies in drug development, a large number of active drug candidates have been found, but many drugs have the defect of poor water solubility, which limits their clinical application. Livestock and poultry use the method of group administration. Considering the convenience of operation, mixed feeding, drinking water and injection are often used in the clinical...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K9/14A61K9/19A61K31/165A61K31/43A61K31/635A61K31/53A61K31/4184A61K31/496A61K31/7048A61K31/498A61P11/06A61P31/04
Inventor 刘兴金张许科张晓会
Owner LUOYANG RUIHUA ANIMAL HEALTH PROD
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