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Mixed sugar electrolyte drug composite injection

A technology of electrolyte and composition, which is applied in the field of medicine, can solve problems such as lack and poor effect, and achieve the effects of reducing metabolic complications, reducing blood sugar fluctuations, and reducing insulin dependence

Inactive Publication Date: 2011-01-19
海南本创医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invert sugar component lacks calcium chloride and zinc sulfate, so it is not suitable for patients who lack calcium and zinc in the human body, and the effect is not good, especially for children, who are in the period of physical development and most of them lack Calcium and zinc, which clearly reflect the defects and deficiencies in the components

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of mixed sugar-electrolyte injection

[0026] prescription:

[0027] Component Dosage

[0028] Glucose (as anhydrous) 30g

[0029] Sodium acetate 0.41g

[0030] Fructose 15g

[0031] Calcium chloride 0.185g

[0032] Xylitol 7.5g

[0033] Magnesium Chloride 0.255g

[0034] Dipotassium Hydrogen Phosphate 0.87g

[0035] Sodium Chloride 0.730g

[0036] Zinc sulfate 0.0007g

[0037] Sodium bisulfite 0.1g

[0038] Water for injection 500ml

[0039] Preparation:

[0040] (1) Dissolve 0.1g of sodium bisulfite in 400ml of water for injection at 40°C, then add 30g of glucose (anhydrous), 15g of fructose and 7.5g of xylitol, mix and stir until completely dissolved;

[0041] (2) in above-mentioned mixed solution, add 0.41g sodium acetate, 0.185g calcium chloride, 0.255g magnesium chloride, 0.87g dipotassium hydrogen phosphate, 0.730g sodium chloride and 0.0007g zinc sulfate, stir to dissolve completely;

[0042] (3) Add water for injection to 500m...

Embodiment 2

[0045] Example 2 Preparation of mixed sugar-electrolyte injection

[0046] prescription:

[0047] Component amount

[0048] Glucose (as anhydrous) 60g

[0049] Sodium acetate 0.82g

[0050] Fructose 30g

[0051] Calcium chloride 0.37g

[0052] Xylitol 15g

[0053] Magnesium Chloride 0.51g

[0054] Dipotassium Phosphate 1.74g

[0055] Sodium Chloride 1.46g

[0056] Zinc sulfate 0.0014g

[0057] Sodium bisulfite 0.1g

[0058] Water for injection 1000ml

[0059] Preparation:

[0060] (1) First dissolve 0.1g of sodium bisulfite in 800ml of water for injection at 45°C, then add 60g of anhydrous glucose, 30g of fructose and 15g of xylitol, mix and stir until completely dissolved;

[0061] (2) in above-mentioned mixed solution, add 0.82g sodium acetate, 0.37g calcium chloride, 0.51g magnesium chloride, 1.74g dipotassium hydrogen phosphate, 1.46g sodium chloride and 0.0014g zinc sulfate, stir to dissolve completely;

[0062] (3) Add water for injection to 1000ml, adjust t...

Embodiment 3

[0065] Example 3 Preparation of mixed sugar-electrolyte injection

[0066] prescription:

[0067] Component Dosage

[0068] Glucose (as anhydrous) 30g

[0069] Sodium acetate 0.41g

[0070] Fructose 15g

[0071] Calcium chloride 0.185g

[0072] Xylitol 7.5g

[0073] Magnesium Chloride 0.255g

[0074] Dipotassium Hydrogen Phosphate 0.87g

[0075] Sodium Chloride 0.730g

[0076] Zinc sulfate 0.0007g

[0077] Sodium metabisulfite 0.1g

[0078] Water for injection 500ml

[0079] Preparation:

[0080] (1) First dissolve 0.1g of sodium metabisulfite in 400ml of water for injection at 50°C, then add 30g of anhydrous glucose, 15g of fructose and 7.5g of xylitol, mix and stir until completely dissolved;

[0081] (2) in above-mentioned mixed solution, add 0.41g sodium acetate, 0.185g calcium chloride, 0.255g magnesium chloride, 0.87g dipotassium hydrogen phosphate, 0.730g sodium chloride and 0.0007g zinc sulfate, stir to dissolve completely;

[0082] (3) Add water for injec...

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PUM

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Abstract

The invention discloses a mixed sugar electrolyte drug composite injection comprising 30 parts of glucose, 0.41 part of sodium acetate, 15 parts of fructose, 0.185 part of calcium chloride, 7.5 parts of xylitol, 0.255 part of magnesium chloride, 0.87 part of dipotassium phosphate, 0.730 part of sodium chloride and 0.0007 part of zinc sulphate. The mixed sugar electrolyte drug composite injection of the invention provides various electrolytes and mixed sugars for organisms, can effectively reduce blood sugar fluctuation, reduces other metabolic complications brought by single monosaccharide energy supply, better provides energy required by gravely ill patients, and has the characteristics of complete metabolism, high energy supply, small blood sugar fluctuation and the like.

Description

technical field [0001] The invention relates to a mixed sugar-electrolyte pharmaceutical composition and a preparation method thereof, in particular, the pharmaceutical composition is an injection, which belongs to the technical field of medicine. Background technique [0002] Critically ill patients often need rehydration therapy for various reasons, and factors such as trauma or stress in critically ill patients make the body in a state of high decomposition, resulting in malnutrition, low immune function, and weakened resistance. The traditional glucose and sodium chloride injection has many defects in the use of critically ill patients, resulting in far more glucose production than utilization, resulting in hyperglycemia. Hyperglycemia causes a large amount of glucose to be lost from the urine, causing osmotic diuresis and increasing the risk of water and electrolyte disturbances; also hyperglycemia is not conducive to wound healing and increases the risk of infection. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/42A61K9/08A61P3/12A61P3/02A61K31/7004A61K31/047A61K33/06A61K33/14A61K31/19A61K33/30
Inventor 王明
Owner 海南本创医药科技有限公司
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