Bioabsorbable material and device using the same to be placed in the living body

A biological and absorbable technology, applied in medical science, surgery, etc., can solve the problems of slow decomposition speed and lack of softness, and achieve the effect of controlling the decomposition speed

Active Publication Date: 2013-05-01
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although this copolymer overcomes the disadvantages of rigid polymers being hard, brittle and lacking in flexibility, it has the problem of slow decomposition speed.

Method used

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  • Bioabsorbable material and device using the same to be placed in the living body
  • Bioabsorbable material and device using the same to be placed in the living body
  • Bioabsorbable material and device using the same to be placed in the living body

Examples

Experimental program
Comparison scheme
Effect test

no. 1 Embodiment approach

[0035] The first embodiment of the bioabsorbable material of the present invention is an aromatic compound component in which an aromatic ring is substituted with an α, β-unsaturated carboxyl group and one or more hydroxyl groups, and a monomer with a polycarbonate component or a polycarbonate Body component copolymer. Therefore, it has flexibility and can control the decomposition rate.

[0036] Examples of aromatic compound components include 2-hydroxycinnamic acid, 3-hydroxycinnamic acid, 4-hydroxycinnamic acid, 4-hydroxy2-methoxycinnamic acid, 4-hydroxy3-methoxycinnamic acid, 3,4-dihydroxycinnamic acid, preferably 4-hydroxycinnamic acid. The reason is that it is highly safe in vivo and can obtain the desired mechanical strength.

[0037] Examples of the polycarbonate component or the monomer component constituting the polycarbonate include trimethylene carbonate and ethylene carbonate, and trimethylene carbonate is preferable. The reason is that the safety in the living body...

no. 2 Embodiment approach

[0053] In the second embodiment of the bioabsorbable material of the present invention, the first aromatic compound component in which the aromatic ring is substituted with α, β-unsaturated carboxyl groups and one or more hydroxyl groups and the aromatic ring are α, β-unsaturated A copolymer of a second aromatic compound component in which a carboxyl group and two or more hydroxyl groups are substituted with a polycarbonate component or a monomer component constituting the polycarbonate. Therefore, it has flexibility and can control the decomposition rate.

[0054] Examples of the first aromatic compound component include 2-hydroxycinnamic acid, 3-hydroxycinnamic acid, 4-hydroxycinnamic acid, 4-hydroxy-2-methoxycinnamic acid, and 4-hydroxy3-methoxycinnamon. The acid is preferably 4-hydroxycinnamic acid. The reason is that it is highly safe in vivo and can obtain the desired mechanical strength.

[0055] As the second aromatic compound component, 3,4-dihydroxycinnamic acid is pref...

Embodiment 1

[0074] 0.066 g of 4-hydroxycinnamic acid (4HCA) and 8.16 g of trimethylene carbonate monomer (TMC) were mixed, 20 μL of octyltin was added, nitrogen replacement was performed three times, and the mixture was stirred in an oil bath at 150° C. for 6 hours under a nitrogen stream. The obtained precipitate was dissolved in chloroform and reprecipitated in methanol. After suction filtration, vacuum drying was carried out at room temperature for two days and nights to obtain oligomeric TMC with a number average molecular weight of Mn=21,800.

[0075] Then, 2.05 g of 4-hydroxycinnamic acid (4HCA), 5.45 g of the above-mentioned oligomeric TMC, 0.05 g of sodium acetate as a catalyst, and 50 mL of acetic anhydride as a transesterification agent were charged into a three-necked flask, and nitrogen gas was bubbled for 10 minutes , Under nitrogen flow, stirring in an oil bath at 180°C for 6 hours for polycondensation. The obtained precipitate was dissolved in dimethylformamide and reprecipit...

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Abstract

A bioabsorbable material which is flexible and degradable at a controlled rate, and an in-vivo indwelling device made thereof. The bioabsorbable material is a copolymer composed of an aromatic compound having an ±,²-unsaturated carboxylic group and at least one hydroxyl group as substituents on the aromatic ring, and a polycarbonate or a monomer constituting polycarbonate. Alternatively, it is a copolymer composed of, as the first component, an aromatic compound having an ±,²-unsaturated carboxylic group and at least one hydroxyl group as substituents on the aromatic ring, as the second component, an aromatic compound having an ±,²-unsaturated carboxylic group and at least two hydroxyl groups as substituents on the aromatic ring, and, as the third component, a polycarbonate or a monomer constituting polycarbonate.

Description

Technical field [0001] The present invention relates to a bioabsorbable material and an indwelling article in a living body using the bioabsorbable material. Background technique [0002] Plastics developed with the advancement of chemistry have been used in all fields as a high-functional material instead of metal and have become one of the indispensable materials. Plastic has established a strong position as an industrial material, led by daily necessities, and its use has greatly expanded from atomic energy to space and ocean development. This plastic is a material with excellent characteristics and possibilities that other raw materials do not have. It is lightweight, easy to mold and process, and products with complex shapes can be manufactured in a few processes, and it has excellent corrosion resistance and chemical resistance. Strong sex and other characteristics. On the other hand, there are also problems such as the lack of heat resistance compared to metals. Since th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/64A61L31/00C08L101/16
CPCC08L69/00A61L31/148A61L31/06C08G63/64C08L101/16
Inventor 明石满松崎典弥藤田阳太郎大西诚人
Owner TERUMO KK
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