Double-controlled release, high-dosage and low-irritation capsaicin compound transdermal patch

Abstract

The invention discloses a double-controlled release, high-dosage and low-irritation capsaicin compound transdermal patch. The patch is divided into an upper layer and a lower layer; a medicament on the upper layer is one or more of menthol, peppermint oil, borneol and a non-steroidal anti-inflammatory medicine which has synergy with capsaicin and can dispel or alleviate local discomfort reaction to the capsaicin, particularly penetrates into the skin more rapidly than the capsaicin to respond, has synergetic therapeutic effect with the capsaicin, and can dispel or alleviate local discomforts such as burning sensation and the like in the initial usage period of the capsaicin; the capsaicin on the lower layer of the patch exists in the form of a cyclodextrin inclusion compound; the patch fully absorbs water after being used on the skin for 6 to 8 hours; and the capsaicin is slowly released from the inclusion compound and penetrates into the skin. The double-controlled release, high-dosage and low-irritation capsaicin compound transdermal patch overcomes the defects of short tolerance time and poor medication compliance of a patient during the transdermal administration of high-dosage capsaicin, and facilitates achieving the maximum pharmacological effect of a medicament.

Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a capsaicin compound transdermal patch with double controlled release, high dosage and low irritation for treating painful neuropathy, neuralgia, musculoskeletal pain and other superficial pain syndromes . Background technique

[0002] Capsaicin is a kind of natural alkaloid extracted and separated from the mature fruit of pepper of Solanaceae plant. There are many capsaicin analogues in natural extracts, including capsaicin and its analogues dihydrocapsaicin, nordihydrocapsaicin, High dihydrocapsaicin, high capsaicin, etc., among which capsaicin is the most pungent and active ingredient. Due to the high cost of extracting and separating high-purity capsaicin, domestic and foreign artificially synthesized capsaicin has been listed. In addition, artificially synthesized capsaicin analogues have also been reported, and studies on the pharmacological effects of capsaicin and its ...

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