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Compound injection for curing viral diseases in livestock and poultry and preparation method thereof

A technology for viral diseases and injections, applied in antiviral agents, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve problems such as toxic side effects, uninfected cell damage, etc., and achieve less toxic side effects and efficacy. Increase and decrease the effect of drug dosage

Inactive Publication Date: 2011-02-09
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current antiviral drugs are some western medicines, which have a certain curative effect on some disease infections, but at the same time also produce a lot of toxic and side effects, and also cause certain damage to uninfected cells, such as ribavirin, Banned drugs such as amantadine have been banned repeatedly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The compound injection for the treatment of livestock and poultry viral diseases of the present embodiment, taking 100ml as an example, its preparation method is as follows:

[0017] 1) Take Andrographis paniculata and Hedyotis diffusa, and extract them with ethanol by alcohol precipitation method: soak in ethanol, filter to remove impurities, and then use vacuum concentration and freeze-drying methods to obtain Andrographis paniculata extract and Hedyotis diffusa extract;

[0018] 2) Weigh 5g of propylene glycol and 0.05g of Tween-80, and dissolve 5g of Andrographis paniculata extract and 1g of Hedyotis diffusa extract into them respectively to obtain solution 1;

[0019] 3) Weigh 2g of taurine and dissolve it in water for injection, adjust the pH to 6.5 to obtain solution 2;

[0020] 4) Take 0.1 g of sodium bisulfite and add water for injection and stir to dissolve to obtain solution 3;

[0021] 5) Combine solutions 1, 2 and 3, add water for injection to 100ml, adjus...

Embodiment 2

[0023] The compound injection for the treatment of livestock and poultry viral diseases of the present embodiment, taking 100ml as an example, its preparation method is as follows:

[0024] 1) Take Andrographis paniculata and Hedyotis diffusa, and extract them with ethanol by alcohol precipitation method: soak in ethanol, filter to remove impurities, and then use vacuum concentration and freeze-drying methods to obtain Andrographis paniculata extract and Hedyotis diffusa extract;

[0025] 2) Weigh 7.5g of propylene glycol and 0.08g of Tween-80, and dissolve 10g of Andrographis paniculata extract and 3g of Hedyotis diffusa extract into them respectively to obtain solution 1;

[0026] 3) Weigh 5g of taurine and dissolve it in water for injection, adjust the pH to 7 to obtain solution 2;

[0027] 4) Take 0.25g of sodium sulfite and add water for injection and stir to dissolve to obtain solution 3;

[0028] 5) Combine solutions 1, 2, and 3, add water for injection to 100ml, and a...

Embodiment 3

[0030] 1) Take Andrographis paniculata and Hedyotis diffusa, and extract them with ethanol by alcohol precipitation method: soak in ethanol, filter to remove impurities, and then use vacuum concentration and freeze-drying methods to obtain Andrographis paniculata extract and Hedyotis diffusa extract;

[0031] 2) Weigh 10g of propylene glycol and 0.1g of Tween-80, and dissolve 15g of Andrographis paniculata extract and 5g of Hedyotis diffusa extract into them respectively to obtain solution 1;

[0032] 3) Weigh 8g of taurine and dissolve it in water for injection, adjust the pH to 7.5 to obtain solution 2;

[0033] 4) Take 0.4 g of sodium thiosulfate and add water for injection and stir to dissolve to obtain solution 3;

[0034] 5) Combine solutions 1, 2 and 3, add water for injection to 100ml, and adjust the pH to 8 to obtain an injection.

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PUM

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Abstract

The invention discloses a compound injection for curing viral diseases in livestock and poultry and a preparation method thereof. 100ml of injection comprises the following components by weight: 5 to 15g of herba andrographitis extract, 1 to 5g of spreading hedvotis extract, 2 to 8g of taurine, 5 to 10g of propylene glycol, 0.05 to 0.1g of Tween-80, 0.1 to 0.4g of antioxygen and the balance of injection water. The compound injection for curing viral diseases in the livestock and the poultry in the invention is prepared from the pure traditional Chinese medicinal preparations including the herba andrographitis extract and the spreading hedvotis extract and has a good antivirus effect; the pure traditional Chinese medicinal ingredients have low toxic and side effects; and when the herba andrographitis and the spreading hedvotis are used in combination with the taurine, the medicinal effects of the herba andrographitis and the spreading hedvotis can be improved, and the dosage amount of the medicament can be reduced at the same time, so that the cost of the injection can be reduced.

Description

technical field [0001] The invention relates to a compound injection for treating bacterial diseases of livestock and poultry, and also relates to a preparation method of the injection, which belongs to the technical field of veterinary medicine. Background technique [0002] With the development of intensive breeding industry, viral diseases of livestock and poultry not only seriously endanger livestock production, but also some zoonotic diseases threaten human health. Since viruses are strictly parasitic in cells, antiviral drugs must selectively destroy or inhibit viruses inside (outside) cells without causing lethal damage to cells, at least to uninfected cells. However, most of the current antiviral drugs are some western medicines, which have a certain curative effect on some disease infections, but at the same time also produce a lot of toxic and side effects, and also cause certain damage to uninfected cells, such as ribavirin, Banned drugs such as amantadine have b...

Claims

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Application Information

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IPC IPC(8): A61K31/185A61K36/748A61P31/12A61K9/08A61P31/04
CPCY02A40/70
Inventor 吴红云李小娜李建正
Owner ZHENGZHOU HOUYI PHARMA
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