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Lincomycin hydrochloride freeze-dried powder injection for livestock injection and preparation method thereof

A technology of lincomycin hydrochloride and freeze-dried powder injection, which is applied in the preparation of lincomycin hydrochloride freeze-dried powder for injection, and the field of lincomycin hydrochloride freeze-dried powder for injection, can solve the problems of not finding invention patents and the like, Achieving the effect of avoiding adverse reactions, simple formula and convenient transportation

Inactive Publication Date: 2011-04-06
商丘市康森动物药品研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention patent of this drug in the field of veterinary medicine for freeze-dried powder injection has not yet been retrieved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prescription (500mL):

[0021] Lincomycin hydrochloride 6 parts

[0022] Mannitol 2 parts

[0023] Phosphate buffer saline 2 parts

[0024] Add water for injection to full amount

[0025] Preparation:

[0026] In an environment with an air cleanliness level of 100,000 and a local level of 100, take 200 mL of water for injection, cool it to 25°C, add 30 g of lincomycin hydrochloride and 10 g of mannitol in the dark and stir to dissolve, and slowly add an appropriate amount of phosphate buffer to make The pH value of the lincomycin hydrochloride solution is between 6.0 and 6.2. Ultrafiltration with an ultrafiltration membrane with a molecular weight cutoff of 10,000 to 50,000 to obtain an ultrafiltrate; add 0.1% g / mL of medicinal activated carbon, stir and adsorb for 30 minutes, and filter through a 0.45 μm microporous membrane; add water for injection to the filtrate to the full amount, Stir well to make the solution mix evenly; filter and sterilize through a 0.22 μ...

Embodiment 2

[0028] Prescription (500mL):

[0029] Lincomycin hydrochloride 6 parts

[0030] Glucose 2 parts

[0031] Phosphate buffer saline 2 parts

[0032] Add water for injection to full amount

[0033] Preparation:

[0034] In an environment with an air cleanliness level of 100,000 and a local level of 100, take 200mL of water for injection, cool to 25°C, add 30g of lincomycin hydrochloride and 10g of glucose in the dark and stir to dissolve, and slowly add an appropriate amount of 2mol / L phosphate buffer , so that the pH value of the lincomycin hydrochloride solution is between 6.0 and 6.2. Ultrafiltration with an ultrafiltration membrane with a molecular weight cutoff of 10,000 to 50,000 to obtain an ultrafiltrate; add 0.1% g / mL of medicinal activated carbon, stir and adsorb for 30 minutes, and filter through a 0.45 μm microporous membrane; add water for injection to the filtrate to the full amount, Stir well to make the solution mix evenly; filter and sterilize through a 0.22 ...

Embodiment 3

[0036] Prescription (500mL):

[0037] Lincomycin hydrochloride 6 parts

[0038] Lactose 2 parts

[0039] 2 parts ammonia water

[0040] Add water for injection to full amount

[0041] Preparation:

[0042] In an environment with an air cleanliness level of 100,000 and a local level of 100, take 200mL of water for injection, cool it to 15°C, add 10g of lactose and 30g of lincomycin hydrochloride in sequence in the dark, stir well to dissolve, slowly add an appropriate amount of 2mol / L ammonia water, Make the pH value of the lincomycin hydrochloride solution between 5.5 and 5.8. Use an ultrafiltration membrane with a molecular weight cut-off of 10,000 to 50,000 to obtain an ultrafiltrate; add 1% g / mL of medicinal activated carbon, stir and absorb for 20 minutes, and filter through a 0.45 μm microporous membrane; add water for injection to the filtrate to the full amount, Stir well to make the solution mix evenly; filter and sterilize through a 0.22 μm microporous membrane t...

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PUM

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Abstract

The invention discloses lincomycin hydrochloride freeze-dried powder injection for livestock injection and a preparation method thereof and belongs to the technical field of veterinary medicines. The lincomycin hydrochloride freeze-dried powder injection comprises the following components: 3 to 30 percent of lincomycin hydrochloride, 0.1 to 90 percent of excipient and 0.1 to 90 percent of additive. The preparation method comprises: adding lincomycin hydrochloride and prescription amount of excipient in water for injection in a sterile environment under a dark condition and fully stirring for dissolution; adding the additive to regulate the pH value to between 4.0 and 6.5; performing ultrafiltration, adding medicinal active carbon, stirring, absorbing and removing a heat source; filtering by 0.45-micrometer micropore filtering film, and fixing volume; filtering by a 0.22-micrometer micropore filter film terminal for sterilization; and charging with nitrogen, filling separately, freeze drying, capping, sealing and storing. The product of the invention is based on a simple formula, has safe quality and high stability, can be prepared by a simple process at low cost and is easy to store and transport.

Description

technical field [0001] The invention relates to a lincomycin hydrochloride freeze-dried powder injection for livestock and poultry injection, and also relates to a preparation method of the lincomycin hydrochloride freeze-dried powder injection, belonging to the technical field of veterinary medicine. Background technique [0002] Lincomycin Hydrochloride, the chemical name is 6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-6,8-dideoxy -D-erythro-α-D-galactopyranoside hydrochloride monohydrate. It is a kind of lincosamide basic antibiotic isolated from Streptomyces, which mainly binds to the 50s subunit of bacterial ribosome, inhibits peptide acyl transferase and inhibits protein synthesis, so as to achieve antibacterial effect. In veterinary medicine, it is often used as a quick-acting drug for inhibiting bacterial growth, especially various infections caused by penicillin-resistant Gram-positive bacteria, poultry chronic respiratory diseases caused by mycopl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/7056A61P31/04
Inventor 饶刚李逐波廖丹丹徐高贤徐泽民
Owner 商丘市康森动物药品研究所
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