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Composite florfenicol injection for livestock and preparation method thereof

A technology of florfenicol and injection, which is applied in the field of livestock and poultry medicine, can solve the problems of large livestock and poultry hazards, achieve remarkable therapeutic effects, broad market prospects, and stable properties

Inactive Publication Date: 2011-04-27
TIANJIN BIJIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, judging from the current development of my country's animal husbandry industry, pasteurellosis, piglet yellow scour, pullorum, typhoid fever, paratyphoid fever, and bacterial enteritis are very harmful to livestock and poultry, and there is no ideal treatment for both symptoms and root causes in the market. Drugs, through some market surveys on effective treatments in this area, it is found that the market urgently needs a drug that has stable drug effects, good curative effect, and is easy to use against pasteurellosis, yellow scour of piglets, pullorum, typhoid, paratyphoid, bacterial There are specific drugs for the spread of sexual enteritis

Method used

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  • Composite florfenicol injection for livestock and preparation method thereof
  • Composite florfenicol injection for livestock and preparation method thereof
  • Composite florfenicol injection for livestock and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A kind of compound florfenicol injection, raw material comprises following components:

[0022] Florfenicol 6g, olaquindox 1g, trimethoprim 1g, anisodamine hydrochloride 0.03g, organic solvent 75g, water for injection 4g.

[0023] The organic solvent is a solution obtained by mixing N, N-dimethylformamide, α-pyrrolidone and benzyl alcohol in a weight ratio of 3; 3; 1, respectively.

[0024] A preparation method of compound florfenicol injection, the steps are as follows:

[0025] (1) Weigh Florfenicol and Trimethoprim, put them into N,N-dimethylformamide, stir for 10-20 minutes until dissolved;

[0026] (2) Heat olaquindox, α-pyrrolidone and benzyl alcohol to 50-60°C and stir for 10-30 minutes until dissolved;

[0027] (3) Anisodamine hydrochloride is dissolved in an appropriate amount of water for injection;

[0028] (4) Combine the solutions prepared by "(1)", "(2)" and "(3)", add the remaining amount of water for injection, stir evenly, and keep for 10-20 minutes....

Embodiment 2

[0030] A kind of compound florfenicol injection, raw material comprises following components:

[0031] Florfenicol 15g, olaquindox 5g, trimethoprim 5g, anisodamine hydrochloride 0.05g, organic solvent 80g, water for injection 8g.

[0032] The organic solvent is a solution obtained by mixing N,N-dimethylformamide, α-pyrrolidone and benzyl alcohol respectively in a weight ratio of 5:5:2.

[0033] A preparation method of compound florfenicol injection, the steps are as follows:

[0034] (1) Weigh Florfenicol and Trimethoprim, put them into N,N-dimethylformamide, stir for 10-20 minutes until dissolved;

[0035] (2) Heat olaquindox, α-pyrrolidone and benzyl alcohol to 50-60°C and stir for 10-30 minutes until dissolved;

[0036] (3) Anisodamine hydrochloride is dissolved in an appropriate amount of water for injection;

[0037] (4) Combine the solutions prepared by "(1)", "(2)" and "(3)", add the remaining amount of water for injection, stir evenly, and keep for 10-20 minutes.

Embodiment 3

[0039] A kind of compound florfenicol injection, raw material comprises following components:

[0040] Florfenicol 10g, olaquindox 3g, trimethoprim 3g, anisodamine hydrochloride 0.04g, organic solvent 78g, water for injection 6g.

[0041] The organic solvent is a solution obtained by mixing N,N-dimethylformamide, α-pyrrolidone and benzyl alcohol respectively in a weight ratio of 4:4:2.

[0042] A preparation method of compound florfenicol injection, the steps are as follows:

[0043] (1) Weigh Florfenicol and Trimethoprim, put them into N,N-dimethylformamide, stir for 10-20 minutes until dissolved;

[0044] (2) Heat olaquindox, α-pyrrolidone and benzyl alcohol to 50-60°C and stir for 10-30 minutes until dissolved;

[0045] (3) Anisodamine hydrochloride is dissolved in an appropriate amount of water for injection;

[0046] (4) Combine the solutions prepared by "(1)", "(2)" and "(3)", add the remaining amount of water for injection, stir evenly, and keep for 10-20 minutes.

...

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Abstract

The invention relates to a composite florfenicol injection and a preparation method thereof. The injection comprises the following components in part by weight: 6 to 15 parts of florfenicol, 1 to 5 parts of olaquindox, 1 to 5 parts of trimethoprim, 0.03 to 0.05 part of anisodamine hydrochloride, 75 to 80 parts of organic solvent and 4 to 8 parts of water for injection, wherein the organic solvent is a solution obtained by mixing N,N-dimethylformamide, alpha-pyrrolidone and benzyl alcohol in the weight part ratio of 3-5:3-5:1-2. In the preparation method, raw materials are dissolved in the water for injection in turn. The composite florfenicol in the components has a scientific formula, is screened through a large number of experiments, has stable property as proved by animal experiments and has long medicament action time, small local stimulation effect, remarkable treating effect and wide market prospect.

Description

technical field [0001] The invention relates to the field of livestock and poultry medicines, in particular to medicines for treating respiratory diseases, in particular to a compound florfenicol injection for livestock and poultry and a preparation method thereof. Background technique [0002] In recent years, with the improvement of people's living standards, the development of animal husbandry and the trend of intensive breeding have gradually become a trend. The stock of livestock and poultry has increased year by year, and the demand for by-products has also increased. The vast market space has accelerated. The breeding industry developed rapidly. However, judging from the current development of my country's animal husbandry industry, pasteurellosis, piglet yellow scour, pullorum, typhoid fever, paratyphoid fever, and bacterial enteritis are very harmful to livestock and poultry, and there is no ideal treatment for both symptoms and root causes in the market. Drugs, thr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/505A61K31/498A61K31/46A61K31/165A61K9/08A61P31/04A61P1/12A61P11/00A61P1/00
Inventor 李华声裴毅聂江力马明娟
Owner TIANJIN BIJIA PHARMA CO LTD
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