Novel squid ink melanin chelate iron preparation method and application of method

A technology of melanin and squid ink, which is applied in the preparation and application field of new squid ink melanin chelated iron, can solve the problems of inability to realize industrial production, poor solubility, and difficult control of the production process, and achieve rich raw materials, high product yield, easy to control effects

Inactive Publication Date: 2011-05-11
OCEAN UNIV OF CHINA
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Problems solved by technology

However, due to the defects in the method at present, when the pH is greater than 4, iron ions are likely to form insoluble ferric hydroxide precipitates, which are difficult to control during the production process and cannot be industrialized. Preparation method of squid ink melanin chelated iron compound

Method used

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  • Novel squid ink melanin chelate iron preparation method and application of method
  • Novel squid ink melanin chelate iron preparation method and application of method
  • Novel squid ink melanin chelate iron preparation method and application of method

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Embodiment

[0009] Example: Weigh 1Kg North Pacific squid ink to separate about 200g of squid ink melanin, weigh 20g, and after vacuum freeze-drying, add 5L containing 10mM FeCl 3 50mM sodium acetate buffer solution, adjust the pH to 6.0, stir at 4°C to disperse the squid ink melanin evenly, stir for 12h; collect the solution, and centrifuge at 4000×g at room temperature to collect the precipitate; finally wash the precipitate repeatedly with distilled water and centrifuging to collect the precipitate 3 times to remove unbound iron ions, and vacuum freeze-dry the gained precipitate to obtain squid ink melanin chelated iron. After analysis, the product is a heteropolymer chelated iron with an indole structure as the main body, with a purity of 89.2% and an iron content of 75 mg / g.

[0010] In this embodiment, the North Pacific squid can be changed to Peruvian squid, red squid, Argentine squid or New Zealand squid, and similar effects can be obtained. The purity of the squid ink melanin ch...

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Abstract

The invention relates to a novel squid ink melanin chelate iron preparation method and the application of the method in preparing anemia and iron deficiency anemia adjuvant therapy health food, functional food or medicines. The method is characterized by the following steps: melanin is separated from the squid ink firstly; the squid ink melanin is added into a buffer solution containing ferrous ions after vacuum freeze drying; the buffer solution is stirred for 8 to 24 hours under the temperature of 4 DEG C to 25 DEG C with the pH value regulated to 5 to 6; 3000-5000*g centrifugal collection for precipitation is carried out under the room temperature; then the precipitate is repeatedly washed by distilled water, and 3000-5000*g centrifugal collection for precipitation and vacuum freeze drying are conducted. The squid ink melanin chelate iron compound prepared through adopting the method utilizes rich and available raw materials and has extremely high melanin content. The method provided by the invention has the advantages of simple procedures, easiness in control, less equipment investment, no environmental pollution, high product yield, etc., and is suitable for industrialized production.

Description

technical field [0001] The invention relates to a preparation method of a novel squid ink melanin chelated iron and its application in the preparation of health food, functional food or medicine for auxiliary treatment of anemia. Background technique [0002] According to the 2002 Nutrition Survey of Chinese Residents, the average prevalence of anemia in Chinese residents is 15.2%; the prevalence of anemia in infants under 2 years old, the elderly over 60 years old, and women of childbearing age are 24.2%, 21.5% and 20.6% respectively. 30% of pregnant women are anemic, and it is even higher in the third trimester. Anemia can generally be divided into two categories: nutritional anemia caused by lack of iron or vitamin B12 and non-nutritive anemia caused by hematopoietic system dysfunction. Among them, nutritional anemia is mainly iron-deficiency anemia. There are many types of iron agents used for iron supplementation, commonly used are ferrous sulfate, ferrous fumarate, fe...

Claims

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Application Information

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IPC IPC(8): A23L1/304A61K31/80A61P7/06A23L33/16
Inventor 王玉明薛长湖王静凤薛勇李兆杰唐庆娟常耀光周鑫李国云
Owner OCEAN UNIV OF CHINA
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