Palonosetron hydrochloride orally disintegrating tablet and preparation method thereof

Abstract

The invention belongs to the field of pharmacy and medical technology, and relates to a palonosetron hydrochloride orally disintegrating tablet and a preparation method thereof. The orally disintegrating tablet comprises the following components in percentage by mass: palonosetron hydrochloride 0.16 to 1.5, mannite 70 to 95, disintegrating agent 1.5 to 15, taste correcting agent 1 to 3, lubricating agent 0.5 to 2, and other auxiliary materials 0 to 15. The manufacturing technology can adopt dry direct tablet compressing. The palonosetron hydrochloride orally disintegrating tablet has the advantages of simple manufacturing technology, low cost and quick effect on indications, is convenient to take, can be disintegrated into fine grains or powder in oral cavity quickly after oral administration, and is particularly suitable for patients who swallow hard and tumor patients with weak physical fitness. The preparation exists in a form of fine grain or powder before reaching the gastrointestinal tract, and the medicine dissolves out in an accelerating manner and is distributed in the gastrointestinal tract in a large area for more absorption points, so that the bioavailability can be improved.

Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, in particular to a palonosetron hydrochloride orally disintegrating tablet and a preparation method thereof. Background technique

[0002] my country's epidemiological survey shows that in 2003, the mortality rate of malignant tumors among urban residents was 94.71 per 100,000, and cancer became the number one cause of death. The 10 cancers with the highest mortality rates were lung cancer, liver cancer, gastric cancer, esophageal cancer, colon cancer, and rectum cancer. and anal cancer, leukemia, breast cancer, nasopharyngeal cancer, cervical cancer, and bladder cancer; the mortality rate of malignant tumor patients in rural residents is higher, 104.01 / 100,000, ranking first among all death diseases, among which the 10 cancers with the highest mortality rate They are liver cancer, stomach cancer, lung cancer, esophagus cancer, colon, rectum and anal cancer, leukemia, breast cancer, nasop...

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