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Analgesic and repercussive qingpeng plastics and preparation method thereof

A film-coating agent and film-forming agent technology, applied in the field of film-coating agent and its preparation, to achieve better curative effect, improve bioavailability, and long-term effect of drug effect

Active Publication Date: 2011-05-18
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are no literature and product reports about the preparation of film-coating agents based on the prescription of the traditional Tibetan medicine Qingpeng ointment by modifying the dosage form.

Method used

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  • Analgesic and repercussive qingpeng plastics and preparation method thereof
  • Analgesic and repercussive qingpeng plastics and preparation method thereof
  • Analgesic and repercussive qingpeng plastics and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0076] According to specific embodiments of the present invention, the preparation method of the present invention may comprise the following steps:

[0077] ① Remove impurities from Oxytropis chinensis, subrhubarb, iron rod hammer, seed myrobalan, myrobalan myrobalan, emblica, benzoin, vine vine, clean and mix;

[0078] ② Weigh 10%-100% of the total weight of the above-mentioned mixed raw materials, decoct 1-4 times with 5-20 times the weight of water, and decoct for 0.5-3 hours each time, collect and combine the extract and volatile oil, filter and Concentrating the extract to form a concentrated solution with a relative density of 1.0-1.5, and adding volatile oil to the concentrated solution to obtain a concentrated solution a;

[0079] Or take 10%-100% of the total weight of the above-mentioned mixed raw materials, and use 5-20 times by weight of 30-90% ethanol to reflux extract 1-4 times, extract 0.5-24 hours each time, collect and combine the extracts, filter After bein...

experiment example 1

[0147] Experimental example 1: Screening experiment of auxiliary materials of Qingpeng coating agent of the present invention

[0148] 1. Screening experiment of skin penetration enhancer:

[0149] ① Selection of skin penetration enhancer

[0150] Weigh 100g Oxytropis, 50g subrhubarb, 75g iron bar hammer, 100g myrobalan, 100g emblical, 35g benzoin, 150g vine vine, 25g musk; grind musk into fine powder; Use water 10 times the total weight of the materials to decoct twice, decoct for 2.5 hours each time, collect and combine the extract and volatile oil, filter and concentrate the extract into a concentrated solution with a relative density of 1.05-1.15, and add the volatile oil to the concentrated The concentrated solution a is obtained from the liquid; take 300g of polyvinyl alcohol and add distilled water, soak overnight to make it fully swell, slowly add 600ml of ethanol, stir continuously and rapidly while adding, make it fully uniform, then slowly add the above concentrate...

experiment example 2

[0179] Experimental example 2: comparative experimental data of Qingpeng film agent of the present invention and Qingpeng ointment action time

[0180] Experimental sample:

[0181] Traditional Qingpeng ointment: provided by Tibet Qizheng Tibetan Medicine Co., Ltd.;

[0182]Qingpeng Ointment 1: Preparation method: ① Purify Oxytropis 100g, Subrhubarb 50g, Iron Bar Hammer 75g, Nucleus myrobalan 100g, Fructus myrobalan 100g, Emlical emblica 100g, benzoin 35g, and vine vine 150g, crush them , mixed evenly, and set aside; ②Weigh 50% of the total weight of the above-mentioned mixed raw materials, use 2.13kg of water, decoct 3 times at 85°C, and decoct for 2 hours each time, collect the extract and volatile oil respectively; filter, Concentrating the extract to a concentrated solution with a relative density of 1.0 to 1.5; adding the volatile oil to the concentrated solution; ③ pulverizing the above-mentioned remaining mixed raw medicine into a 100 μm powder, and mixing it with the ...

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Abstract

The invention provides analgesic and repercussive Qingpeng plastics. The Qingpeng plastics comprise active ingredients and a matrix, wherein the active ingredients are prepared from the following bulk pharmaceutical chemicals in parts by weight: 80-120 parts of whin, 30-70 parts of Asian rhubarb, 50-100 parts of pendulous monkshood root, 80-120 parts of pit-removed medicine terminalia fruit, 80-120 parts of billeric terminalia fruit, 80-120 parts of emblic leafflower fruit, 20-50 parts of benzoin, 130-170 parts of chinese tinospora stem, and 10-40 parts of forest musk; and the matrix comprises the following adjuvants in parts by weight: 10-1500 parts of film forming agent, and 25-4000 parts of ethanol. The invention also provides the preparation method of the plastics. The plastics can be attached on an affected part for a long period of time as a medicine carrier to achieve the purpose of slow release of the active ingredients, so that the medicament action is long-lasting.

Description

technical field [0001] The invention relates to a film-coating agent and a preparation method thereof, in particular to a film-coating agent for relieving pain and swelling and a preparation method thereof. Background technique [0002] Qingpeng Ointment is a classic Tibetan medicine prescription composed by Tibetan folk doctors based on the records of "Tibetan Medicine and Supplements" and "Four Medical Codes", combined with practical experience. The prescription is included in the 95th edition of "Drug Standards issued by the Ministry of Health" The first volume of medicine, 322 pages. The prescription of Qingpeng ointment is: [0003] Oxytropis falciparum 100g, rhubarb sub 50g, hammer 75g, myrobalan 100g, myrobalan 100g, emblical 100g, benzoin 35g, vine vine 150g, musk 25g. [0004] Preparation method: the above nine flavors, except musk, which are ground into fine powder, the rest are ground into fine powder, sieved, added musk fine powder, mixed evenly, mixed with 8-y...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K9/00A61K9/70A61P29/00A61P19/06A61P17/00A61K35/55
Inventor 陈根平卢伍党张樱山张国霞陈丽娟
Owner TIBET QIZHENG TIBETAN MEDICINE
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