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Method for detecting medicinal composition for treating viral hepatitis

A detection method and composition technology, applied in the direction of drug combination, antiviral agent, pharmaceutical formula, etc., can solve the problems of drug resistance, obvious side effects, addiction, etc.

Active Publication Date: 2011-06-15
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the drugs currently used clinically for the treatment of viral hepatitis have certain curative effects, they have defects such as easy to cause drug resistance, addiction, and obvious side effects in the body to varying degrees.

Method used

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  • Method for detecting medicinal composition for treating viral hepatitis
  • Method for detecting medicinal composition for treating viral hepatitis
  • Method for detecting medicinal composition for treating viral hepatitis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0037] Experimental Example 1: Pharmacodynamic test of the drug group on liver protection, enzyme reduction, choleretic, jaundice reduction, phagocytosis and clearance

[0038] Drug group I: get the pharmaceutical composition mixture prepared in Example 2 of the present invention

[0039] Drug group II: take the pharmaceutical composition mixture prepared in Example 13 of the present invention

[0040] Control group: commercially available Qingre Shugan mixture.

[0041] 1. Hepatoprotective and enzyme-lowering effects

[0042] 1. Protective effect on acute liver injury

[0043] Take 84 Kunming mice, weighing 18-20 g, half male and half male, and randomly divide them into 7 groups. The first group: the normal control group, fed with the same amount of drinking water every day; the second group: the model group, fed with the same amount of drinking water every day; Equivalent to 9.32g of crude drug) / kg body weight per day; Group 4: drug group II, 30ml of drug solution of dru...

experiment example 2

[0066] Experimental Example 2 Excipient screening experiment

[0067] Optimization of Inclusion Process Conditions of Volatile Oil β-Cyclodextrin

[0068] Because the volatile oil is easy to lose, if the volatile oil is directly added, it will be lost for a long time or slightly heated, thereby reducing the content and affecting the curative effect of the medicine. In order to solve this problem, the method of β-cyclodextrin inclusion was adopted, and the conditions of inclusion were optimized by orthogonal experiment.

[0069] See the accompanying drawings for the experimental procedure.

[0070] Inclusion by saturated aqueous solution method: Weigh a certain amount of β-cyclodextrin, add appropriate amount of distilled water, and heat it in a 70°C water bath to prepare a 5% aqueous solution of β-cyclodextrin. At different temperatures (20°C, 40°C, 60°C) stirring at a speed of 2500 rpm, adding a certain amount of volatile oil, stirring fully for a certain period of time, to o...

experiment example 3

[0081] Experimental example 3 Identification test of capillary

[0082] Preparation of blank samples According to the medicinal taste and dosage ratio of the medicinal group of the present invention, a group of medicines not containing capillary root, white peony root, angelica sinensis, salvia miltiorrhiza, and knotweed was prepared respectively, and blank preparations were made according to the preparation process.

[0083] Preparation of blank solution Take the daily dose of blank sample 14 / 1000 of the pharmaceutical composition preparation capillary, add 20ml of water to dissolve, extract 2 times with ethyl acetate, 30ml for the first time, 20ml for the second time, and combine the ethyl acetate solution , evaporated to dryness in a water bath, and the residue was dissolved by adding 1ml of ethyl acetate as a blank solution.

[0084] Preparation of the sample solution Take the same amount of samples of the drug group and substance, and prepare the sample solution according...

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Abstract

The invention discloses a method for detecting a medicinal composition for treating viral hepatitis. The medicinal composition is prepared from the following raw material medicaments: virgate wormwood herb, indigowoad root, male fern rhizome, Indian buead, root-tuber of aromatic turmeric, barbed skullcap herb, patchouli and the like. The method for detecting the medicinal composition is obtained by screening a great number of specific creative tests. In an identification method, the identification specificity is high by screening sample processing methods and selecting a developing solvent; and the method is economic and practical, is used for quickly acquiring results and can be applied to different thin layer plates. In a content detecting method, the quality of products can be effectively controlled by screening samples and sample supply processing methods and selecting the developing solvent. The products detected by the method have more stable medicinal effects than products detected by other methods.

Description

[0001] The present invention is a divisional application, and the original application number is 200710119920.5 , the filing date of the original case is 2007 August 3 , the original case name is A kind of pharmaceutical composition and quality control method for treating viral hepatitis Law . field of invention [0002] The invention relates to a pharmaceutical composition, a preparation method and a quality control method, in particular to a pharmaceutical composition for treating viral hepatitis, a preparation method and a quality control method. Background technique [0003] Viral hepatitis is a common infectious disease caused by a variety of hepatitis viruses. It has the characteristics of strong infectivity, complex transmission routes, wide epidemic range, and high incidence rate. Clinically, the main manifestations are fatigue, loss of appetite, nausea, vomiting, hepatomegaly and liver function damage. Some patients may have jaundice and fever. Some patients ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066G01N30/02G01N30/90A61P1/16A61P31/14A61P31/20A61K35/10
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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