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Glipizide sustained release tablets and preparation method thereof

A technology of glipizide and sustained-release tablets, which is applied in the field of pharmaceuticals, can solve the problems of inability to release the drug stably for a long time, many times of administration, and high incidence of toxic and side effects, and achieve stable and effective blood drug concentration, increase residence time, The effect of reducing toxic side effects

Inactive Publication Date: 2011-06-29
SHANDONG FANGMING PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved in the present invention is to disclose a sustained-release tablet containing glipizide, so as to overcome the problems in the prior art that the drug cannot be released stably for a long time in the body, the number of administrations is high, and the incidence of toxic and side effects is high. to improve patient safety and compliance

Method used

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  • Glipizide sustained release tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Glipizide 5g

[0022] Hypromellose (K4M) 46g

[0023] 36g pregelatinized starch

[0024] Microcrystalline Cellulose 70g

[0025] 80% ethanol appropriate amount

[0026] Magnesium Stearate 2g

[0027]

[0028] Makes 1000 pieces

Embodiment 2

[0030] Glipizide 5g

[0031] Hypromellose (K4M) 46g

[0032] Pregelatinized starch 56g

[0033] Microcrystalline Cellulose 50g

[0034] 85% ethanol appropriate amount

[0035] Magnesium Stearate 2g

[0036]

[0037] Makes 1000 pieces

Embodiment 3

[0039] Glipizide 5g

[0040] Hypromellose (K4M) 46g

[0041] Microcrystalline Cellulose 104g

[0042] 85% ethanol appropriate amount

[0043] Magnesium Stearate 2g

[0044]

[0045] Makes 1000 pieces

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Abstract

The invention discloses a prescription of glipizide sustained release tablets. The prescription comprises the following components in percentage by weight: 0.02-0.2% of glipizide, 20-30% of sustained-release matrix material, 65.8-78.48% of disintegrating agent and filling agent, a proper amount of wetting agent and 0.5-4.0% of lubricating agent. The glipizide sustained release tablets disclosed by the invention are clinically used for treating mild-moderate type II diabetes, and can realize stable drug release and maintain blood concentration for a long time after oral administration, thus reducing administration times and greatly improving medication safety and compliance of a patient. The glipizide sustained release tablets disclosed by the invention have the advantages of simple preparation process, applicability to large-scale industrial production and wide application prospects.

Description

technical field [0001] The invention relates to a preparation method of a slow-release tablet containing glipizide, which belongs to the technical field of medicines. Background technique [0002] Glipizide is a colorless, odorless white powder, insoluble in water and ethanol, with a pKa of 5.9. Its English name is Glipizide, and its chemical name is 1-cyclohexyl-3-{4-[2-(5-methylpyrazine-2-amide)-ethyl]benzenesulfonyl}urea. Its structural formula is as follows: [0003] [0004] Molecular formula: C21H27N5O4S, molecular weight: 445.54 [0005] Glipizide is a second-generation sulfonylurea oral hypoglycemic drug, which can promote the secretion of insulin by pancreatic β cells and enhance the effect of insulin on target tissues; it can also stimulate pancreatic α cells to inhibit glucagon secretion. Inhibit liver glycogen breakdown, promote muscle utilization and consumption of glucose. Clinically, it is mainly used for patients with mild to moderate non-insulin-depen...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/64A61K47/38A61P3/10
Inventor 孟爱红崔改英穆子齐苏贵勇
Owner SHANDONG FANGMING PHARMACEUTICAL CO LTD
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