Paramagnetic-upconversion luminous composite nanometer particle, preparation method and application thereof

A composite nanoparticle and nanoparticle technology, which is applied in wave energy or particle radiation treatment materials, drug combinations, pharmaceutical formulations, etc., can solve problems such as separation, achieve uniform particle size distribution, good biocompatibility, and simple preparation methods Effect

Active Publication Date: 2011-06-29
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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AI-Extracted Technical Summary

Problems solved by technology

[0005] The invention provides a preparation method of paramagnetic-upconversion luminescent composite nanoparticles, which solves the current problem of ...
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Abstract

The invention discloses a paramagnetic-upconversion luminous composite nanometer particle, preparation method and application thereof, wherein the preparation method comprises the following steps of: compounding the nanometer particle with paramagnetism or raw material for preparing the nanometer particle with paramagnetism and the nanometer particle with upconversion luminous performance or the raw material for preparing the nanometer particle with upconversion luminous performance via reaction so as to prepare the paramagnetic-upconversion luminous composite nanometer particle. The paramagnetic-upconversion luminous composite nanometer particle prepared by the method is a composite nanometer material with MRI (magnetic resonance imaging) radiography and upconversion luminous performance, wherein the paramagnetic nanometer particle component has T1 or T2 weighted MRI radiography, and can be used as a magnetic resonance imaging contrast agent and a light power treatment nanometer material.

Application Domain

Powder deliveryEnergy modified materials +3

Technology Topic

T2 weightedParamagnetism +6

Image

  • Paramagnetic-upconversion luminous composite nanometer particle, preparation method and application thereof
  • Paramagnetic-upconversion luminous composite nanometer particle, preparation method and application thereof

Examples

  • Experimental program(6)

Example Embodiment

[0031] Example 1
[0032] First prepare NaYF 4 :Er 3+ /Yb 3+ Nanoparticles, respectively take 0.1mol/L of Y(NO 3 ) 3 Aqueous solution 20mL, 0.1mol/L Yb(NO 3 ) 3 Aqueous solution 2mL and 0.1mol/L Er(NO 3 ) 3 0.2mL aqueous solution, mix and stir, and add 0.1mol/L morphology control agent and complexing agent sodium citrate aqueous solution 25mL to it, keep stirring for 30min, then add 0.4mol/L NaF aqueous solution 90mL, after fully stirring for 60min , transfer the mixed solution to a polytetrafluoroethylene-lined hydrothermal reactor for reaction, the reaction temperature is 180 °C, and the reaction time is 120 min; finally, the resultant is centrifuged, washed 3 times, dried and ground to obtain NaYF 4 :Er 3+ /Yb 3+ Nano particle powder, the size is 20-25nm.
[0033] Take prepared NaYF 4 :Er 3+ /Yb 3+ Nanoparticle powder dissolved in deionized water to prepare 0.01mol/L NaYF 4 :Er 3+ /Yb 3+ Nanoparticle aqueous sol 100mL, ultrasonic and fully stirred, add 0.01mol/L PEG solution 5mL to it, keep stirring for 1h; then weigh 5mmol of FeCl 3 and 2.5 mmol FeCl 2 , added to it and stirred thoroughly; finally, 1mmol/L of NH was added to the mixed solution 3 ·H 2 O 20mL, after fully stirring for 30min, add 10mL of 1mmol/L SDS aqueous solution to the mixed solution, continue stirring for 30min, and finally separate and dry the product to obtain Fe 3 o 4 -NaYF 4 :Er 3+ /Yb 3+ composite nanoparticles.
[0034] Produced Fe 3 o 4 -NaYF 4 :Er 3+ /Yb 3+ The size of composite nanoparticles is 20-40nm, with T 2 Weighted MRI contrast function, under the irradiation of 980nm laser, can emit visible light.
[0035] Prepared Fe 3 o 4 -NaYF 4 :Er 3+ /Yb 3+ The XRD spectrum of composite nanoparticles (Cu Kα target, λ=0.15418nm) is as figure 1 ,from figure 1 The cubic phase NaYF can be seen in 4 and cubic phase Fe 3 o 4 diffraction peaks, indicating that the prepared Fe 3 o 4 -NaYF 4 :Er 3+ /Yb 3+ Composite nanoparticles with Fe 3 o 4 and NaYF 4 crystal structure.
[0036] Adopt the comprehensive physical property testing system of Quantum Design in the United States, model Model-9; test conditions: VSM (vibrating sample magnetometer) test, temperature 300K, test the prepared Fe 3 o 4 -NaYF 4 :Er 3+ /Yb 3+ Magnetization curves of composite nanoparticles, such as figure 2. from figure 2 It can be seen that Fe 3 o 4 -NaYF 4 :Er 3+ /Yb 3+ The saturation magnetization of composite nanoparticles is about 41.4emu/g, and its coercivity and remanence are both 0, indicating that Fe 3 o 4 -NaYF 4 :Er 3+ /Yb 3+ Composite nanoparticles are superparamagnetic.

Example Embodiment

[0037] Example 2
[0038] ZnFe with a size of 10-20nm 2 o 4 Nanoparticles dissolved in deionized water to prepare 0.01mol/L ZnFe 2 o 4 Add 5 mL of 0.005 mol/L dopamine solution to 100 mL of nanoparticle hydrosol, ultrasonically and thoroughly stir for 30 min; then add 0.1 mol/L Y(NO 3 ) 3 Aqueous solution 20mL, 0.1mol/L Yb(NO 3 ) 3 Aqueous solution 2mL, 0.1mol/L Tm(NO 3 ) 3 Aqueous solution 0.2mL, 0.1mol/L sodium citrate aqueous solution 25mL, after magnetic stirring for 30min; then add 0.4mol/L NaF aqueous solution 90mL, magnetically stir at 60°C for 120min; finally add 0.5mmol/L CTAB to the mixed solution 10mL aqueous solution, continue to stir for 30min, centrifuge the product, wash with water, and dry to obtain ZnFe 2 o 4 -NaYF 4 :Yb 3+ /Tm 3+ composite nanoparticles.
[0039] Prepared ZnFe 2 o 4 -NaYF 4 :Yb 3+ /Tm 3+ The size of composite nanoparticles is 20-40nm, with T 2 Weighted MRI imaging function, under the irradiation of 980nm laser, can emit ultraviolet light.

Example Embodiment

[0040] Example 3
[0041] Measure 0.1mol/L of Y(NO 3 ) 3 Aqueous solution 40mL, 0.1mol/L Yb(NO 3 ) 3 Aqueous solution 2mL, 0.1mol/L Tm(NO 3 ) 3 Aqueous solution 0.4mL, 0.25mol/L Gd(NO 3 ) 3 Aqueous solution 1.5mL, 0.1mol/L EDTA aqueous solution 30mL, continue to stir for 30min, then add 0.4mol/L NaF aqueous solution 90mL, after fully stirring for 60min, transfer the mixture to a polytetrafluoroethylene-lined hydrothermal reaction kettle Carry out the reaction, the reaction temperature is 160°C, and the reaction time is 120min; finally, the resultant is centrifuged, washed with water, and dried to obtain Gd-NaYF 4 :Yb 3+ /Tm 3+ composite nanoparticles.
[0042] Gd-NaYF 4 :Yb 3+ /Tm 3+ The size of composite nanoparticles is 10-30nm, with T 1 Weighted MRI imaging function, under the irradiation of 980nm laser, can emit ultraviolet light.

PUM

PropertyMeasurementUnit
Size1.0 ~ 100.0nm
Saturation magnetization41.4emu/g

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