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Isocyano group-blocking anti-calcification artificial biological valve and preparation method thereof

An isocyano, biological valve technology, applied in the field of medical devices, can solve the problems of valve recession, difficult survival of endothelial cells, etc., and achieve the effects of improving anti-calcification performance, simple and easy preparation method, and improving long-term stability and durability.

Active Publication Date: 2013-12-11
SHANGHAI MICROPORT CARDIOFLOW MEDTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, glutaraldehyde toxicity makes it difficult for the host's own endothelial cells to survive on the valve, which is also an important reason for valve decline
The disadvantages of the simple glutaraldehyde modification method must use a new type of capping group to modify the artificial biological valve in order to achieve excellent anti-calcium effect

Method used

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  • Isocyano group-blocking anti-calcification artificial biological valve and preparation method thereof
  • Isocyano group-blocking anti-calcification artificial biological valve and preparation method thereof
  • Isocyano group-blocking anti-calcification artificial biological valve and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. The artificial biological valve glutaraldehyde-NaCl-Na 2 HPO 4 -NaHCO 3 Fix in the compound buffer solution for 10 days.

[0033] 2. Put the artificial biological valve pretreated with glutaraldehyde into a solution containing 2,4-toluene diisocyanate for 5 hours.

[0034] 3. Put the artificial biological valve pretreated with glutaraldehyde and treated with the solution of 2,4-toluene diisocyanate into a glycerol solution for 40 days, and then into an ethylene glycol solution for 30 days.

Embodiment 2

[0036] 1. The artificial biological valve glutaraldehyde-NaCl-Na 2 HPO 4 -NaHCO 3 -Fixed in penicillin compound buffer solution for 15 days.

[0037] 2. Put the artificial biological valve pretreated with glutaraldehyde into a solution containing 2,6-toluene diisocyanate for modification for 10 hours.

[0038] 3. Put the artificial biological valve pretreated with glutaraldehyde and the solution of 2,6-toluene diisocyanate into a sorbitol solution for 50 days, and then into a 1,4-butanediol solution for treatment 30 days.

Embodiment 3

[0040] 1. The artificial biological valve glutaraldehyde-KCl-K 2 HPO 4 -KHCO 3 -Fixed in the compound buffer solution of streptomycin for 20 days.

[0041] 2. Put the artificial biological valve pretreated with glutaraldehyde into a solution containing hexamethylene diisocyanate for modification for 20 hours.

[0042] 3. Put the artificial biological valve pretreated with glutaraldehyde and treated with the solution of hexamethylene diisocyanate into a pentaerythritol solution for 40 days, and then into a 1,4-butanediol solution for 50 days.

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Abstract

The invention belongs to the field of medical devices and relates to an isocyano group-blocking anti-calcification artificial biological valve and a preparation method thereof. The method comprises the following steps: immersing the artificial biological valve in glutaraldehyde solution after pretreatment; using glutaraldehyde for fixing partially before, after or during the step of enabling the artificial biological valve to be in contact with the glutaraldehyde after the pretreatment; and blocking free amine, hydroxyl groups, aldehyde groups and carboxyl groups in the artificial biological valve after the pretreatment through isocyano groups, polyol groups and polydiol groups. The isocyano group blocking method is mainly adopted during the process of performing chemical modification on the artificial biological valve, thereby greatly improving the anti-calcification performance of the artificial biological valve and improving the long-term stability and the durability of the artificial biological valve.

Description

Technical field [0001] The invention belongs to the field of medical devices, and relates to an isocyano-terminated anti-calcification artificial biological valve and a preparation method thereof. Background technique [0002] In the preparation process of the artificial biological valve, calcification is the primary factor of biological valve failure, and calcium salt deposition is the most significant pathological feature. Biological valve calcification mostly occurs at the valve junction and base, that is, the most stressed part of the valve when the valve is opened and closed. It is yellow nodular mass and fragile. The calcification of biological valve is mostly deposited in the form of calcium phosphate, and phosphorus is also closely related to the calcification of biological valve. Power loss spectroscopy analysis showed that the locally accumulated high concentration of phosphorus was related to the cell membranes in the unimplanted glutaraldehyde-treated porcine aortic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36
Inventor 陈大凯李雨陈诚王云蕾刘翔陈国明林韶烨乐承筠罗七一
Owner SHANGHAI MICROPORT CARDIOFLOW MEDTECH CO LTD