Use of ginsenoside Rg1 in preparation of antidepressant

A ginsenoside and anti-depressant technology, applied in the medical and health field, can solve the problem of little anti-depressant effect, achieve the effect of less toxic side effects, high safety, and sufficient sources

Inactive Publication Date: 2011-07-20
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, there are still relatively few antidepressant studies at the monomer level. Some monomers that have been studied so far include: ginsenoside Rg2 described in CN200410086457.5 , 20(s)-protopanaxadiol described in CN200610027507.1, 20(s)-protopanaxadiol derivatives described in CN200610116353.3, 20(S)-ginsenosides described in CN200810043537.0 Ginsenoside Rb3 described in Rh2 and CN201010193222.1
Wherein also only ginsenoside Rg2 described in CN200410086457.5 is panaxatriol type saponin, so the antidepressant effect research about the saponin monomer of panaxatriol type is also few at present
[0010]As for the relatively high content of ginsenoside Rg1 in Panax notoginseng, it also belongs to panaxatriol-type saponins, but whether it has antidepressant effect has not yet been See the report

Method used

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  • Use of ginsenoside Rg1 in preparation of antidepressant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Mouse tail suspension experiment

[0039] 1 Materials and methods

[0040] 1.1 Experimental animals

[0041] SPF-grade Kunming mice, male, weighing 18-22 g, were purchased from the Experimental Animal Center of Sun Yat-sen University School of Medicine, license number: SCXK (Guangdong) 2009-0011.

[0042] Standard feed and litter were purchased from the Experimental Animal Center of Sun Yat-sen University School of Medicine.

[0043] 1.2 Drugs and instruments

[0044] Drugs: Ginsenoside Rg1 was purchased from Yunnan Plant Pharmaceutical Co., Ltd.; the positive drug maprotiline was purchased from Guangzhou Jianmin Pharmacy.

[0045] Automated photographic analysis system for mouse tail suspension experiment; mouse gavage needles for experiments, etc., were purchased from Huaibei Zhenghua Biological Instruments and Equipment Co., Ltd.

[0046] 1.3 Liquid preparation

[0047] Take ginsenoside Rg1 and dissolve it in distilled water, and make solutions with lo...

Embodiment 2

[0056] Example 2 Mice Forced Swimming Experiment

[0057] 1 Materials and methods

[0058] 1.1 Experimental animals

[0059] SPF-grade Kunming mice, male, weighing 18-22 g, were purchased from the Experimental Animal Center of Sun Yat-sen University School of Medicine, license number: SCXK (Guangdong) 2009-0011.

[0060] Standard feed and litter were purchased from the Experimental Animal Center of Sun Yat-sen University School of Medicine.

[0061] 1.2 Instruments and medicines

[0062] Drugs: Ginsenoside Rg1 was purchased from Yunnan Botanical Pharmaceutical Co., Ltd.; positive drugs paroxetine and maprotiline were purchased from Guangzhou Jianmin Pharmacy.

[0063] Instruments: ZH-QPT forced swimming device and analysis system, ZH-QPT opening experiment device and analysis system, mouse gavage needles for experiments, all purchased from Huaibei Zhenghua Biological Instrument Equipment Co., Ltd.; thermometer.

[0064] 1.3 Liquid preparation

[0065] Take ginsenoside Rg1...

Embodiment 3

[0081] Example 3 Acquired Helplessness Experiment

[0082] 1 Materials and methods

[0083] 1.1 Experimental animals

[0084] SPF-grade Kunming mice, male, weighing 18-22 g, were purchased from the Experimental Animal Center of Sun Yat-sen University School of Medicine, license number: SCXK (Guangdong) 2009-0011.

[0085] Standard feed and litter were purchased from the Experimental Animal Center of Sun Yat-sen University School of Medicine.

[0086] 1.2 Instruments and medicines

[0087] Drugs: Ginsenoside Rg1 was purchased from Yunnan Plant Pharmaceutical Co., Ltd.; the positive drug maprotiline was purchased from Guangzhou Jianmin Pharmacy.

[0088] Instruments: BA-200 dark avoidance instrument for mice, purchased from Chengdu Taimeng Technology Co., Ltd.; mouse gavage needles for experiments, purchased from Huaibei Zhenghua Biological Instruments and Equipment Co., Ltd.

[0089] 1.3 Liquid preparation

[0090] Take ginsenoside Rg1 and dissolve it in distilled water, a...

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Abstract

The invention belongs to the field of medicine and health and particularly relates to the use of a natural compound, namely a ginsenoside monomer Rg1, in the preparation of an antidepressant. A test dose of ginsenoside Rg1 can reduce dead time of a mouse in a tail suspension experiment and obviously reduce the dead time of a mouse in a forced swimming experiment and the times of escape failures of a mouse in a learned helplessness experiment, which shows that the ginsenoside Rg1 has a remarkable antidepressant effect and can be used for preventing and treating depression.

Description

technical field [0001] The invention belongs to the field of medical and health care, and relates to the use of natural compounds in the field of medicine, more specifically the use of ginsenoside Rg1 in the preparation of antidepressant drugs. Background technique [0002] Ginsenoside Rg1, the molecular formula is C 42 h 72 o 14 , with a molecular weight of 801.01, is a protopanaxatriol type saponin, which is soluble in methanol, pyridine, hot acetone, and slightly soluble in ethyl acetate and chloroform. CAS: 22427-39-0, EINECS: 244-989-9. Its structural formula is as Figure 5 . [0003] Studies have shown that the DNA biosynthesis of bone marrow cells increased significantly after intraperitoneal injection of 100mg / kg Rg1 in rats for 4 hours; the biosynthesis of protein or lipid has roughly the same tendency as the biosynthesis of DNA; It can also reduce the contraction of the isolated uterus of guinea pigs caused by acetylcholine; it has the effect of slowing down ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P25/24
Inventor 项辉刘映雪张晗杨斌黄掌欣郭静
Owner SUN YAT SEN UNIV
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