Method for synthesizing N,N-diethyl ethanolamine

A diethylethanolamine and synthesis method technology, applied in the N field, can solve the problems of high reaction temperature, expensive catalyst, etc., and achieve the effects of avoiding side reactions, increasing equipment utilization, and reducing the probability of side reactions

Active Publication Date: 2011-07-20
ZHEJIANG JIANYE CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the above-mentioned several methods for synthesizing N, N-diethylethanolamine have certain operability, they all have certain defects, such as expensive catalysts, high reaction temperature, and the need to use circulating media, etc.

Method used

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  • Method for synthesizing N,N-diethyl ethanolamine
  • Method for synthesizing N,N-diethyl ethanolamine
  • Method for synthesizing N,N-diethyl ethanolamine

Examples

Experimental program
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Effect test

Embodiment 1

[0022] In a Φ30mm metal tubular reactor with a total length of 2m, 731.4g / h (10mol / h) of diethylamine, 88.1g / h (2.0mol / h) of ethylene oxide, and Catalyst zinc chloride 7g / h was added continuously, cooling water at 25°C was introduced into the jacket of the reactor, and the flow rate of cooling water was adjusted to keep the reaction temperature basically constant at 50±5°C. The composition of the final analysis reaction liquid is: DEA70.9%, catalyst 0.8%, DEEA28.1%, high boiler 0.2%.

Embodiment 2

[0024] In a Φ30mm metal tubular reactor with a total length of 2m, 731.4g / h (10mol / h) of diethylamine, 176.2g / h (4.0mol / h) of ethylene oxide, and Catalyst zinc chloride 7g / h was added continuously, cooling water at 25°C was introduced into the jacket of the reactor, and the flow rate of cooling water was adjusted to keep the reaction temperature basically constant at 50±5°C. The composition of the final analysis reaction liquid is: DEA48.6%, catalyst 0.7%, DEEA49.2%, high boiling substances 1.5%.

Embodiment 3

[0026] In a Φ30mm metal tubular reactor with a total length of 2m, 731.4g / h (10mol / h) of diethylamine, 88.1g / h (2.0mol / h) of ethylene oxide, and Catalyst ferric chloride 7g / h was added continuously, cooling water at 25°C was passed into the jacket of the reactor, and the flow rate of cooling water was adjusted to keep the reaction temperature basically constant at 50±5°C. The composition of the final analysis reaction liquid is: DEA71.1%, ethylene oxide 0.1%, catalyst 0.8%, DEEA27.8%, high boiler 0.2%.

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Abstract

The invention discloses a method for synthesizing N,N-diethyl ethanolamine, which is to synthesize N,N-diethyl ethanolamine in one step in the presence of a catalyst by using diethylamine and ethylene oxide as raw materials, wherein the molar ratio of diethylamine to ethylene oxide in the reaction is (1-15):1, the synthesis reaction temperature is controlled to be 10 to 180 DEG C, the catalyst is added continuously at a speed of 5 to 10g / h, and the added amount is 0.1 to 2.0 percent based on the total mass of the catalyst and the two materials. The method has the following advantages that: 1) pure diethylamine instead of aqueous solution of diethylamine is used as the reaction raw material, so the energy consumption is low and the equipment efficiency is high; and 2) a tubular reactor with a jacket is adopted to transfer heat conveniently, which is favorable continuous operation.

Description

technical field [0001] The invention relates to the field of pharmaceutical intermediates, in particular to a method for synthesizing N,N-diethylethanolamine. Background technique [0002] N,N-diethylethanolamine can be used as a pharmaceutical intermediate to prepare procaine hydrochloride, kebetidine, and kemephen, etc.; it can also be used as a solvent to remove acidic gases in natural gas and refinery gas Such as hydrogen sulfide and carbon dioxide, in addition, it can also be used to prepare derivatives of fatty acids, fiber softeners, antirust agents, emulsifiers, vulcanization catalysts for polyurethane foam, etc. [0003] There are many ways to synthesize N, N-diethylethanolamine. Most of them in China use the aqueous solution of diethylamine to react with ethylene oxide. This process obviously has the disadvantages of low reaction efficiency and many side reactions. [0004] In addition, as in U.S. Patent No. 4,745,190, diethylamine and ethylene glycol are used as ...

Claims

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Application Information

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IPC IPC(8): C07C215/08C07C213/00
Inventor 冯烈陈云斌强林萍刘尚文
Owner ZHEJIANG JIANYE CHEM
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