Medicinal composition containing candesartan cilexetil and hydrochlorothiazide and preparation method thereof

Abstract

The invention relates to a medicinal composition containing candesartan cilexetil and hydrochlorothiazide and a preparation method thereof. The medicinal composition comprises the following components in parts by weight: 4 or 8 parts of candesartan cilexetil, 6.25 parts of hydrochlorothiazide, 60 to 100 parts of lactose monohydrate, 15 to 40 parts of microcrystalline cellulose, 2.6 parts of croscarmellose sodium, 2.6 parts of polyglycol 6000, and 1.3 parts of magnesium stearate. After the medicinal composition is uniformly mixed, an 8 percent high-substitution hydroxypropyl cellulose aqueous solution is used as a binder to granulate by a wet method and to tablet. In the method, by adopting a certain amount of the polyglycol 6000 as a stabilizer, the preparation stability is remarkably improved; and over 90 percent of dissolution rate can be achieved in 45 minutes by adopting less disintegrant and binder; the preparation method has a simple production process without adding extra equipment; the tablets produced according to the method has good stability and high disintegration speed, so that the dissolution of the medicament is remarkably improved, and measurement proves that: the dissolution of the tablets prepared by adopting the method reaches over 90 percent in 45 minutes.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a pharmaceutical composition containing candesartan cilexetil and hydrochlorothiazide and a preparation method thereof. Background technique [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. The main goal of treating hypertension is to minimize the risk of cardiovascular morbidity and mortality. At present, the prevalence of hypertension in the world is 31.3%, and those who die from hypertension-related diseases account for 6% of the world's death population every year. Hypertension is one of the most important independent risk factors for cardiovascular disease. It often coexists with dyslipidemia, insulin resistance, diabetes, or obesity, causing damage to important target organs such as the heart, brain, and kidneys, and is associated with stroke, coronary heart disease, and kidney disease. are clos...

AI Technical Summary

Problems solved by technology

In this patent, polyethylene glycol 6000 is preferred as the low melting point oily compound in the examples, but the dosage is 6.0 parts by weight, which is relatively large, and the dissolution rate of the preparation is not good.

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