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Compound spray for treating cardiovascular and cerebrovascular diseases and preparation method of compound spraying

A cardiovascular and cerebrovascular disease and spray technology, which is applied in the field of medicine, can solve problems such as dangers caused by improper use, troublesome absorption effects, and difficult reversal of effects, and achieve the effects of avoiding liver inactivation, fast onset of action, and improved stability.

Active Publication Date: 2011-08-10
TIANSHENG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical application, the compound injection has rapid drug effect, but its quality requirements are high, the preparation process requires specific conditions and equipment, the production cost is relatively high, the price is high, it is inconvenient to use, it is painful during injection, and the effect on the body is difficult to reverse. Improper use prone to danger
Compound dripping pills carry a small amount of medicine, correspondingly low drug content, large dosage, and inconvenient to carry. Like tablets, it is more troublesome to take, and the absorption effect is not good, and the onset of effect is slow.

Method used

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  • Compound spray for treating cardiovascular and cerebrovascular diseases and preparation method of compound spraying
  • Compound spray for treating cardiovascular and cerebrovascular diseases and preparation method of compound spraying
  • Compound spray for treating cardiovascular and cerebrovascular diseases and preparation method of compound spraying

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A compound spray for treating cardiovascular and cerebrovascular diseases, prepared according to the following preparation method:

[0033] a. respectively dissolving the crude drug consisting of the salvia miltiorrhiza extract and the total saponins of Panax notoginseng in ethanol; the extract of salvia miltiorrhiza in the bulk medicine accounts for 25%, and the total saponins of notoginseng accounts for 75%, calculated by weight percentage;

[0034] b. Add the solubilizing agent accounting for 1% to 10% of the total weight of the product solution into the mixed solution of the above-mentioned Danshen extract ethanol solution and Panax notoginseng saponins ethanol solution, mix well, pack in containers, press the cap, and The solubilizer is polysorbate, tween20, tween40, tween60 or tween80;

[0035] c. After capping, press the propellant filtered through the microporous membrane into the bottle under the pressure of 800kpa to get final product; the propellant is Freon,...

Embodiment 2

[0037] A compound spray for treating cardiovascular and cerebrovascular diseases, prepared according to the following preparation method:

[0038] a. Add 70%wt ethanol 13 times its weight to the Salvia miltiorrhiza extract, dissolve and stir to dissolve, and set aside; Add the alcohol solution of the salvia miltiorrhiza extract, stir to dissolve; wherein the salvia miltiorrhiza extract of the crude drug accounts for 42%, and the total saponins of notoginseng account for 58%, calculated by weight percentage;

[0039] b. The solubilizer Tween 20, which accounts for 3% of the total weight of the product solution, is added to the mixed solution of the above-mentioned Danshen extract ethanol solution and Panax notoginseng saponins ethanol solution. In the aerosol pressure-resistant container, with a gland;

[0040] c. After capping, press the propellant HFA-134a filtered through the microporous membrane into the bottle under a pressure of 900kpa to obtain final product; the consum...

Embodiment 3～9

[0042] Carry out by following material and processing condition, other are all identical with embodiment 2. The prepared spray of the present invention has good stability, no flocculation-like precipitation occurs for as long as 6-12 months, stable properties and remarkable curative effect.

[0043]

[0044]

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Abstract

The invention provides a compound spray for treating a cardiovascular and cerebrovascular diseases, which is prepared by mixing pharmaceutic adjuvant to ethanol solution of raw material drug to prepare solution; the raw material drug includes 25 to 68 percent of red sage root extract, and 32 to 75 percent of panax notoginseng saponins in weight percentage; the medical assistant includes a solubilizer and a propellant, wherein the solubilizer is 1 to 10 percent the total weight of the solution; and the solubilizer is one or more of polysorbate, fatty acid sorbitan, polyoxyethylene aliphatic ester, polyoxyethylene fatty alcohol ether, and polyoxyethylene-polyoxypropylene copolymer. The compound spray uses the panax notoginseng saponins and the red sage root extract as the main drugs for quickly treating the cardiovascular and cerebrovascular diseases; the compound can exert coordination effect, particularly during the acute exacerbation period of the cardiovascular and cerebrovascular diseases, the compound spray works fast, so as to reach the expected treatment effect and have obvious treatment effect.

Description

technical field [0001] The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, in particular to a compound spray for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Cardiovascular and cerebrovascular diseases are the number one killer that endangers human life and health. According to statistics, 17 million people died of cardiovascular diseases in the world in 2000, accounting for 1 / 3 of the total number of deaths from various causes in the world. It is estimated that by 2020 This number will increase to 25 million, 80% of which are in developing countries. Therefore, the prevention and treatment of cardiovascular and cerebrovascular diseases has been listed as one of the national key issues. With the increase of the incidence of cardiovascular diseases, it will be a very meaningful work to ...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/12A61P9/10
Inventor 刘群刘行鹏昝琼李达富
Owner TIANSHENG PHARMA GROUP
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