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High-purity geniposide as well as preparation and clinical application of preparations thereof

A high-purity technology of geniposide, used in the preparation of sugar derivatives, anti-inflammatory agents, non-central analgesics, etc.

Inactive Publication Date: 2011-10-12
肖文辉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extraction rate of gardenia yellow is about 90% based on ultraviolet rays

Method used

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  • High-purity geniposide as well as preparation and clinical application of preparations thereof
  • High-purity geniposide as well as preparation and clinical application of preparations thereof
  • High-purity geniposide as well as preparation and clinical application of preparations thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0083] Extraction and purification of geniposide

[0084] Take gardenia jasmine, crush it into a coarse powder, percolate with 40% ethanol, collect the percolation liquid, concentrate until the volume and weight of the medicinal material are 1:1, and filter with suction to obtain the product. The extraction rate of geniposide is about 90%. The extraction rate of gardenia yellow is about 90% based on ultraviolet rays.

[0085] Take the above-mentioned solution and the dry resin ratio and put it on the AB-8 macroporous resin column that has been treated at a ratio of 1:2 to 1.5:2, and control the flow rate at 0.5-0.8ml / min to fully absorb the gardenia yellow and geniposide, and then use Elute with 5 times the volume of the solution, discard the eluate, continue to elute with 5 times the volume of 30% ethanol, and collect the eluate (which is the geniposide component). Concentrate the collected 30% ethanol eluate, dry and finely grind to obtain crude geniposide (with a content ...

example 2

[0088] Preparation of Geniposide for Injection

[0089] ① Prescription

[0090]

[0091] ② preparation

[0092] Take geniposide and add appropriate amount of water to dissolve, add hydrochloric acid or sodium hydroxide solution to adjust the pH value, 3.5-9, add mannitol, decolorize with activated carbon, remove pyrogen, set the volume to 200ml, filter through a microporous membrane, sterile Subpackaged and freeze-dried injections (lyophilized needles).

example 3

[0094] ① Prescription

[0095]

[0096] Add starch and carboxymethyl starch sodium to geniposide, mix well, add binder to make soft material, after drying, granulate; add magnesium stearate in appropriate amount, mix well and pack separately to make capsules; or press into tablets to make tablets agent.

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Abstract

The invention provides high-purity geniposide as well as preparation and clinical application of preparations thereof. Gardenia is a dried and matured fruit of rubiaceae plant gardenia and has liver-protecting, chole-promoting, pressure-reducing, heat-clearing, cold-promoting and diarrhea-relieving functions and the like. The geniposide is a product which is obtained by refining the dried and matured fruit of the rubiaceae plant gardenia by virtue of a high-technology production process and is an iridoid glycoside compound. The geniposide is used for treating cardiovascular and cerebrovascular diseases, hepatic and biliary diseases, diabetes mellitus and the like. At present, a lot of methods for extracting the geniposide and gardenia pigment from the gardenia are reported in documents, but a plenty of problems exit, such as the product contains high impurity content so that the requirements of customers at home and abroad can not be satisfied, the production cost is high, the yield is low, the economic benefits are poor, the methods are not suitable for industrial production, and the like. According to the invention, the problems are solved. The high-purity geniposide is obtained by virtue of extraction and purification of gardenia and is prepared into proper preparations such as tablets, capsules, particles, injecta, powder injections, infusion solutions and the like to be applied to the clinic for treating cardiovascular and cerebrovascular diseases, hepatic and biliary diseases, diabetes mellitus and the like.

Description

1. Technical field [0001] The invention belongs to the preparation and clinical application of high-purity geniposide and its preparation. 2. Background technology [0002] Gardenia jasminoides is the dry and mature fruit of Rubiaceae plant Gardenia jasminoides Ellis. As a traditional Chinese medicine, it has the functions of protecting the liver, promoting gallbladder, lowering blood pressure, clearing away heat, benefiting cold, and antidiarrheal. [0003] Geniposide is a product extracted and refined from the dried and mature fruit of Gardenia jasminoides of the Rubiaceae plant using high-tech production technology. It is an iridoid glycoside compound. Geniposide has many uses, and it is a raw material drug for treating diseases such as cardiovascular and cerebrovascular diseases, liver and gallbladder, and diabetes. [0004] At present, there are many reports on the method of extracting gardenia pigment and geniposide from gardenia, but there are many problems, such as ...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08A61K31/7048A61P1/16A61P29/00A61P9/12A61P9/00A61P1/12A61P3/10C09B61/00
Inventor 肖文辉熊祥珍
Owner 肖文辉
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