Chinese medicinal composition for preventing and treating injury of gastric mucosa and preparation method thereof

A technology for gastric mucosal injury and composition, which is applied in the field of traditional Chinese medicine composition for preventing and treating gastric mucosal injury and its preparation field, can solve the problems of easy generation of drug resistance, large side effects, easy recurrence and the like, achieves prevention and treatment of gastric mucosal diseases, protection The effect of gastric mucosa

Active Publication Date: 2011-11-02
SHIJIAZHUANG ZANGNUO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Drugs currently on the market for treating gastric mucosal injury include antacids (sodium bicarbonate, etc.), gastric mucosal protective agents (

Method used

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  • Chinese medicinal composition for preventing and treating injury of gastric mucosa and preparation method thereof
  • Chinese medicinal composition for preventing and treating injury of gastric mucosa and preparation method thereof
  • Chinese medicinal composition for preventing and treating injury of gastric mucosa and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0032] Example 1:

[0033] 1. Composition (weight):

[0034] Astragalus 50g, Poria 22g, Dandelion 17g, Evodia 10g, Angelica dahurica 10g, Calcined oyster 5g.

[0035] 2. Preparation method:

[0036] 1) Separately screen, pick, sort, and process various drugs with the above weight ratio;

[0037] 2) Astragalus, Poria, Dandelion, and Evodia decoction are decocted twice with water, 10 times the amount of water is added each time, and decocted for 2 hours. Concentrate under reduced pressure to (-0.065Mpa, 75°C) to a clear paste with a relative density of 1.30-1.35 (measured at 60°C);

[0038] 3) The concentrated solution is vacuum dried (-0.085Mpa, 65°C) to obtain a dry extract, which is crushed through a 100-mesh sieve to obtain fine powder A;

[0039] 4) Angelica dahurica is crushed into fine powder and passed through a 100-mesh sieve; oyster (calcined) is crushed and passed through an 80-mesh sieve and mixed to obtain fine powder B;

[0040] 5) Mix powders A and B, add 9.1 g of dextrin and...

Example Embodiment

[0041] Example 2: Determination of extraction process parameters

[0042] Based on the summary and induction of the literature, combined with the actual production experience, the preparation of this preparation is formulated to operate as follows:

[0043] 1) Baizhi, oyster (calcined) powder is used as medicine;

[0044] 2) Astragalus, Tuckahoe, Dandelion, Evodia, decocted in water, filtered, and the filtrate is concentrated into a clear cream;

[0045] 3) Drying, pulverizing, mixing, granulating, sizing, filling and packaging the above-mentioned high pressure and reduced pressure.

[0046] In order to make some technical parameters of the crushing process and the extraction process more specific, the process parameters such as the powder extraction rate, the amount of solvent added, the extraction time, and the number of extractions were investigated respectively.

[0047] 1. Investigation of crushing process

[0048] 1.1 Investigation of the crushing process of Angelica dahurica medici...

Example Embodiment

[0098] Example 3: Safety investigation

[0099] 1. Material

[0100] 1.1 Experimental drug: The drug prepared according to Example 1, named Huangpu Fuling capsule or test substance, provided by Shijiazhuang Zangnuo Biotechnology Co., Ltd., and the content is brown granules and powder. The recommended daily dose for adults is 2100mg / 60kg.BW.

[0101] 1.2 Experimental animals: Kunming mice and SD rats were provided by the Laboratory Animal Research Institute of Sichuan Academy of Medical Sciences, production license number: SCXK (Sichuan) 2004-16.SPF level.

[0102] 2. Test method

[0103] 2.1 Acute toxicity test in rats and mice:

[0104] Twenty Kunming mice and 20 SD rats each, half male and half, mice weigh 18-22g, and rats weigh 180-220g. Rats and mice are randomly divided into two groups, 10 mice in each group, half male and half male. . The experiment set a dose group of 15000mg / kg·BW according to the maximum tolerated dose method. Weigh 75g of the test substance and add distille...

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Abstract

The invention discloses a Chinese medicinal composition for preventing and treating injury of gastric mucosa and a preparation method thereof. The Chinese medicinal composition comprises the active ingredients prepared from the following Chinese medicines in part by weight: 24 to 65 parts of astragalus, 18 to 40 parts of Indian buead, 5 to 26 parts of Mongolian dandelion herb, 3 to 15 parts of medicinal evodia fruit, 3 to 21 parts of angelica dahurica and 0.5 to 9 parts of calcined oyster shell. The invention also provides a preparation containing the Chinese medicinal composition and a preparation method thereof. The Chinese medicinal composition for preventing and treating the injury of gastric mucosa has the effects of supplementing qi and tonifying spleen, clearing away heat and eliminating dampness and lowering adverse flow of qi and harmonizing stomach under the action of the medicines to achieve the effect of protecting the gastric mucosa. Experiments prove that the Chinese medicinal composition can be used for preventing and treating gastric mucosa diseases.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine, in particular to a traditional Chinese medicine composition for preventing and treating gastric mucosal damage and a preparation method thereof. Background technique [0002] Gastric mucosal disease is the most common disease among many stomach diseases. The clinical manifestations are pantothenic acid, belching, nausea, vomiting or chronic mid-upper abdominal pain after meals. In severe cases, there may be melena and hematemesis. With the accelerated pace of social life and huge work pressure, it often leads to irregular eating, non-drinking or overeating. At the same time, people's eating habits, eating preferences, overeating, spicy and alcoholism are all important causes of gastric mucosal damage. According to statistics, the incidence of gastrointestinal diseases in the United States is 10% for men and 5% for women: 5-10% for Japan; 12.3% for Germany. The average incidence of gast...

Claims

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Application Information

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IPC IPC(8): A61K36/754A61P1/04A61K35/56A61K35/618
Inventor 王智森高飞
Owner SHIJIAZHUANG ZANGNUO BIOTECH
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