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Poly (alkene carbonate) diol-polylactic acid segmented copolymer and preparation method thereof

A technology of polycarbonate diol and block copolymer, which is applied in the field of preparation of polycarbonate diol-polylactic acid block copolymer, which can solve the problem of limited application range and long PLLA degradation cycle and other issues to achieve the effect of simplifying the process operation

Inactive Publication Date: 2011-11-16
JIANGSU ZHONGKE JINLONG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the degradation process of PLLA at body temperature, excessive local lactic acid concentration will cause inflammation; at the same time, PLLA has a high degree of crystallinity, so the degradation cycle of PLLA is relatively long, which limits its application in the medical field

Method used

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  • Poly (alkene carbonate) diol-polylactic acid segmented copolymer and preparation method thereof
  • Poly (alkene carbonate) diol-polylactic acid segmented copolymer and preparation method thereof
  • Poly (alkene carbonate) diol-polylactic acid segmented copolymer and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0019] Put 0.1g of polyethylene carbonate diol with a molecular weight of 1000g / mol, 100g of lactide and 0.01g of stannous octoate fully dried in advance into a 250ml narrow-mouth bottle, vacuumize to below 30Pa, and fill it into a dry High-purity nitrogen, and then repeat the vacuuming-nitrogen filling operation for more than 5 times, and finally vacuumize to 10Pa, seal the reaction bottle, heat up to 180°C, and react for 6 hours to finally obtain polycarbonate with a molecular weight of 86Kg / mol and a molecular weight distribution of 1.99. Ethylene glycol-polylactic acid block copolymer.

Embodiment 2

[0021] 20.0g of polyethylene carbonate diol with a molecular weight of 1200g / mol, 30.0g of polypropylene carbonate diol with a molecular weight of 500g / mol, 100.0g of lactide and 0.015g of dibutyl oxidation Put the tin into a 250ml narrow-mouth bottle, vacuumize it to below 30Pa, fill it with dry high-purity nitrogen, then repeat the vacuumize-nitrogen filling operation 5 times, and finally vacuumize it to 12Pa, seal the reaction bottle, and raise the temperature to 160°C. After reacting for 12 hours, a polycarbonate diol-polylactic acid block copolymer with a molecular weight of 58Kg / mol and a molecular weight distribution of 1.71 was finally obtained.

Embodiment 3

[0023] 30.0g of polyethylene carbonate diol with a molecular weight of 2000g / mol, 30.0g of polypropylene carbonate diol with a molecular weight of 1500g / mol, and 40.0g of polybutylene carbonate with a molecular weight of 2000g / mol were fully dried in advance. Put alcohol, 100g lactide, 0.001g dibutyltin oxide, and 0.001g tributyltin oxide into a 250ml narrow-mouth bottle, vacuumize to less than 30Pa, fill with dry high-purity nitrogen, and then repeat vacuuming — Nitrogen filling operation 6 times, finally vacuumize to 5Pa, seal the reaction bottle, heat up to 150°C, react for 16 hours, and finally obtain polycarbonate diol-polylactic acid block with a molecular weight of 66Kg / mol and a molecular weight distribution of 1.53 copolymer. The NMR spectrum of the obtained copolyester is as figure 1 shown.

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Abstract

The invention relates to a poly (alkene carbonate) diol-polylactic acid segmented copolymer and a preparation method thereof. A copolyester of the invention is a segmented copolymer generated from ring-opening copolymerization of poly (alkene carbonate) diol with a weight-average molecular weight of 500-10000g / mol and lactide. Specifically, the preparation method comprises the steps of: subjecting a previously fully dried reactant and lactide as well as a ring-opening catalyst to a vacuum-pumping-nitrogen charging metathesis operation in a container for 5-10 times, then pumping high vacuum to a pressure of 5-15Pa, raising the temperature to a range of 110-180DEG C, and leaving the reaction to proceed for 6-72h, thus finally obtaining the poly (alkene carbonate) diol-polylactic acid segmented copolymer of high molecular weight. Wherein, the reactant can be one or more of poly (ethylene carbonate) diol, poly (propylene carbonate) diol and poly (butylene carbonate) diol. According to the invention, the technological operation is simplified. The chain segment length of a final product and the molecular weight of the copolymer can be adjusted by controlling the molecular weight and the adding amount of the poly (alkene carbonate) diol so as to obtain copolyesters of different performances.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and relates to a polycarbonate diol-polylactic acid block copolymer, and also relates to a preparation method of the copolyester. Background technique [0002] Polyethylene carbonate is a polymer material polymerized by carbon dioxide and epoxy compounds. Among them, aliphatic polyglycol carbonate has good biodegradability, and this type of polyester generally has good low temperature Flexibility, gas barrier and transparency make it useful as a carrier for drug sustained-release systems, film packaging materials, solid electrolytes, surface treatment of inorganic fillers, etc. However, due to the poor thermal stability of aliphatic poly(glycol carbonate), its practical application in various fields is seriously affected. [0003] In the research of aliphatic poly(ethylene carbonate), poly(ethylene carbonate) diol, poly(butylene carbonate) diol, polypropylene carbonate diol and other c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/64C08G63/08
Inventor 徐玉华
Owner JIANGSU ZHONGKE JINLONG CHEM
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