Use of andrographolides

A technology of andrographolide and total andrographolide, applied in the application field of andrographolide, can solve the problems of reducing triglyceride, increasing HDL-C, reducing total cholesterol and the like

Active Publication Date: 2011-11-23
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drugs currently used to lower blood lipids include statins, which mainly lower total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), and also lower triglycerides (TG) and raise high-density lipoprotein cholesterol (HDL-C). The effect of -C); fibrates are mainly used to lower triglycerides, and have the effect of lowering total cholesterol and LDL-C and raising HDL-C; bile acid sequestrants mainly reduce total cholesterol and LDL-C; Simvastatin is a clinically effective drug, but it is more toxic to the liver

Method used

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  • Use of andrographolides
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  • Use of andrographolides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of andrographolide

[0014] Weigh 1kg of Andrographis paniculata crude powder and put it in a 10L round bottom flask, add 10 times the amount of 70% ethanol, heat and reflux in the electric heating mantle to extract twice, each time for 3h, filter, after combining the filtrates, remove the solvent under reduced pressure, place in 60 Dry under reduced pressure at ℃ to constant weight to obtain total andrographolide, and then absorb pigment by activated carbon to obtain total andrographolide with an andrographolide content greater than 50%, and then separate and purify through silica gel chromatographic column to obtain andrographolide, new Monomer components of andrographolide, dehydroandrographolide and deoxyandrographolide.

[0015] The specific operation can also refer to the description in the examples in the Chinese patent application CN200910115426.0.

Embodiment 2

[0016] Embodiment 2: Lipid-lowering experiment of andrographolide on hyperlipidemic mice

[0017] Preparation of the test solution

[0018] Take 5, 50, and 125 mg of andrographolide respectively and put them in a 25ml volumetric flask, add 150 μL of DMSO to dissolve, then dilute to the mark with sterilized normal saline, and disperse evenly with ultrasonic waves, and prepare low, medium, and high doses of andrographolide for testing liquid.

[0019] Then respectively take neoandrographolide, dehydroandrographolide and deoxyandrographolide each monomer compound 5, 50, 125 mg, the same method as above to prepare the test solution. Another 25 mg of simvastatin was placed in a 25 ml volumetric flask, sterilized saline was added, dispersed evenly by ultrasound, and a positive control substance of corresponding concentration was prepared for the test solution.

[0020] experiment procedure

[0021] 180 mice were divided into random groups, 12 in each group, each test solution was...

Embodiment 3

[0030] Embodiment 3: Lipid-lowering experiment of andrographolide on hyperlipidemic rats

[0031] High Fat Emulsion Formulation

[0032] Take 100g of lard, put it in a 2000ml beaker, heat and melt it on an electric stove, add 50g of cholesterol, and melt it for later use; take another 10g of sodium cholate, 3g of propylthiouracil, 50ml of Tween-80, 50ml of propylene glycol and 700ml of distilled water Heat to dissolve in another beaker, disperse evenly with lard at a high speed of 12000 rpm while hot, and then dilute with water to 1500ml.

[0033] Preparation of the test solution

[0034] Take 250mg and 1000mg of andrographolide respectively and put them in a 50ml volumetric flask, add 150μL of DMSO to dissolve, then dilute to the mark with sterilized normal saline, ultrasonically disperse evenly, and prepare high (20mg / ml) and low dose (5mg / ml) andrographolide test solution.

[0035] Take 250mg and 1000mg dehydroandrographolide, deoxyandrographolide and neoandrographolide,...

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Abstract

The invention discloses the use of andrographolides, dehydrated andrographolides, new andrographolides and deoxidized andrographolides, which refers to the use of at least one of the andrographolides, the dehydrated andrographolides, the new andrographolides and the deoxidized andrographolides as a unique active component in preparation of medicinal preparations for preventing and treating hyperlipidaemia. In the invention, a new medical value of andrographolide compounds is developed.

Description

technical field [0001] The invention relates to an application of andrographolide, in particular to the application of andrographolide in the preparation of pharmaceutical preparations for the prevention and treatment of hyperlipidemia and / or atherosclerosis, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Andrographolide (Andrographolide, AND) is a lactone compound extracted from Andrographis paniculata (Burm.f.) Nees, also known as Andrographis paniculata (Burm.f.) Nees, also known as Andrographolide B. One of the main active ingredients. There are a series of lactone compounds in Andrographis paniculata, mainly including: andrographolide 1, dehydroandrographolide 2, neoandrographolide 3 and deoxyandrographolide 4, etc., and its chemical structure is as follows: [0003] [0004] Andrographolide has antibacterial, antipyretic, cough and asthma effects, and is clinically used to treat upper respiratory tract inflammation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K31/7048A61K36/19A61P3/06A61P9/10
Inventor 王长虹王峥涛程雪梅杨涛盛欢欢
Owner SHANGHAI UNIV OF T C M
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