Method for preparing glabridin
A technology of licorice and licorice, applied in the field of preparation of licorice, can solve the problems of low efficiency, long column chromatography elution period and the like, and achieves controllable process parameters, large preparation amount and short production cycle. Effect
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[0019] Example 1:
[0020] Take light licorice and crush it, take 1kg, put it into a microwave extraction tank, add 8 times 80% ethanol for microwave extraction for 60 minutes, filter the liquid, add 6 times 80% ethanol solution for microwave extraction for 30 minutes, combine the two extracts and concentrate under reduced pressure Without alcohol, take 1% sodium hydroxide solution to adjust the neutrality of the concentrated solution, transfer to a separatory funnel, add equal volume of ethyl acetate for extraction 3 times, and then extract the extract twice with 5% sodium bicarbonate solution, and concentrate the organic phase , Add 50g of polyamide and dry to get a sample. Take chloroform, methanol, and aqueous solution at a mixing ratio of 7:5:3. Remove the phase as an entrainer, pulverize the sample and add it to the extraction kettle. Adjust the parameter pressure to 12MPa, extraction temperature 40°C, and introduce liquid CO 2 Fluid, after reaching the above parameters, CO...
Example Embodiment
[0021] Example 2:
[0022] Take light licorice and crush it, take 1kg, put it into a microwave extraction tank, add 6 times the amount of 70% ethanol for microwave extraction for 40 minutes, extract 3 times, combine the 2 extracts and concentrate under reduced pressure without alcohol, take 0.5% sodium hydroxide solution to adjust the concentrated solution Neutral, transfer to a separatory funnel, add an equal volume of ethyl acetate for extraction 4 times, and then extract the extract 3 times with 5% sodium bicarbonate solution, concentrate the organic phase, add 80 g of polyamide and dry to obtain a sample. Take chloroform, methanol, and aqueous solution at a mixing ratio of 8:5:3. Remove the phase as an entrainer. Crush the sample and add it to the extraction kettle. Adjust the parameter pressure to 16MPa, extraction temperature 30°C, and introduce liquid CO 2 Fluid, after reaching the above parameters, CO 2 The flow rate was controlled to 120ml / min, the entrainer flow rate was...
Example Embodiment
[0023] Example 3:
[0024] Take light licorice and crush it, take 5kg, put it into a microwave extraction tank, add 6 times the amount of 70% ethanol for microwave extraction for 40min, extract 3 times, combine the 2 extracts and concentrate under reduced pressure without alcohol, take 0.2% sodium hydroxide solution to adjust the concentrated solution Neutral, transfer to a separatory funnel, add 2 times the volume of ethyl acetate to extract 3 times, and then extract the extract with 5% sodium bicarbonate solution 2 times, concentrate the organic phase, concentrate the organic phase, add 400g polyamide to dry, get sample. Take chloroform, methanol, and aqueous solution at a mixing ratio of 8:6:3, take the phase off as an entrainer, pulverize the sample and add it to the extraction kettle, adjust the parameter pressure to 14MPa, extraction temperature 35°C, and pass liquid CO 2 Fluid, after reaching the above parameters, CO 2 The flow rate was controlled to 200ml / min, the entrain...
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