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Release mass transfer rate adjustable intelligent drug delivery carrier and preparation method thereof

A technology of drug delivery carrier and rate, which is applied in the field of drug delivery carrier and its preparation relying on external environmental stimuli to realize the controllable speed-adjusted release of drugs. Effects of avoiding toxic and side effects, regulating drug release rate, and reducing mass transfer resistance

Active Publication Date: 2011-11-30
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that for the smart microcapsule drug delivery system designed based on the above types, due to its "on-off" drug release mode, the controlled release of drugs is often in two extreme states of "on" or "off". The release and mass transfer rate cannot be flexibly adjusted according to the patient's specific condition and treatment effect, which limits its clinical application
So far, the research on the intelligent microcapsule drug delivery system has mainly focused on how to further improve the environmental response rate of the microcapsule and the development of microcapsules with multiple response functions. system, has not been reported at home and abroad

Method used

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  • Release mass transfer rate adjustable intelligent drug delivery carrier and preparation method thereof
  • Release mass transfer rate adjustable intelligent drug delivery carrier and preparation method thereof
  • Release mass transfer rate adjustable intelligent drug delivery carrier and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0047] The processing steps of the present embodiment are as follows:

[0048] (1) Preparation of thermosensitive submicrospheres

[0049] A device for preparing thermosensitive submicrospheres such as Figure 5 As shown, it comprises a three-necked glass flask 20, a constant temperature circulating water bath 21, and a magnetic stirrer 23. One port of the three-necked glass flask 20 is connected to a spherical condenser tube 18, and the remaining two ports are respectively inserted with a nitrogen-through glass tube 19, and the three-necked glass flask 20 A magnetic stirrer 22 is arranged inside;

[0050] Add monomer N-isopropylacrylamide, acrylamide and allylamine, cross-linking agent N, N'-methylenebisacrylamide, initiator potassium persulfate to deionized water at room temperature and normal pressure to form a mixed solution , in the mixed solution, the concentration of N-isopropylacrylamide is 0.07mol / L, the molar ratio of acrylamide to N-isopropylacrylamide is 0.2:1, a...

Embodiment 2

[0066] The processing steps of the present embodiment are as follows:

[0067] (1) Preparation of thermosensitive submicrospheres

[0068] The device for preparing temperature-sensitive submicrospheres is the same as in Example 1. Add monomer N-isopropylacrylamide, acrylamide and allylamine, cross-linking agent N, N'-methylene bisacrylamide, initiator ammonium persulfate to deionized water at room temperature and normal pressure to form a mixed solution , in the mixed solution, the concentration of N-isopropylacrylamide is 0.1mol / L, the molar ratio of acrylamide to N-isopropylacrylamide is 0.025:1, allylamine and N-isopropylacrylamide The molar ratio of the ammonium persulfate is 0.025:1, the concentration of ammonium persulfate is 0.25g / L, the molar ratio of N,N'-methylenebisacrylamide and N-isopropylacrylamide is 0.05:1,

[0069] Add the mixed solution into a three-necked glass flask 20, raise the temperature of the mixed solution to 60° C. in a nitrogen atmosphere, and re...

Embodiment 3

[0080] The processing steps of the present embodiment are as follows:

[0081] (1) Preparation of thermosensitive submicrospheres

[0082] The device for preparing temperature-sensitive submicrospheres is the same as in Example 1. Add monomer N-isopropylacrylamide, cross-linking agent N,N'-methylenebisacrylamide, initiator azobisisobutylamidine hydrochloride to deionized water at room temperature and normal pressure to form a mixed solution , in the mixed solution, the concentration of N-isopropylacrylamide is 0.05mol / L, the concentration of azobisisobutylamidine hydrochloride is 0.4g / L, and N,N'-methylenebisacrylamide The molar ratio with N-isopropylacrylamide is 0.1:1,

[0083] Add the mixed solution into a three-necked glass flask 20, raise the temperature of the mixed solution to 70°C in a nitrogen atmosphere and react at this temperature for 5 hours. After the reaction, the reaction solution is centrifugally washed with deionized water to obtain poly( N-isopropylacryla...

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Abstract

The invention discloses a release mass transfer rate adjustable and controllable intelligent drug delivery carrier, which is a hollow spherical microcapsule. A membrane of the microcapsule mainly comprises poly[methacrylic-N, N-dimethylamino ethyl ester], super-paramagnetic Fe3O4 nanoparticles and poly(N-isopropyl acrylamide) temperature-sensitive sub-microspheres or poly[N-isopropyl acrylamide-copoly-acrylamide-copoly-allyl amine] temperature-sensitive sub-microspheres. A process for preparing the drug delivery carrier comprises the following steps of: (1) preparing the temperature-sensitivesub-microspheres; (2) preparing modified super-paramagnetic Fe3O4 magnetic fluid; (3) preparing intermediate phase fluid, inner phase fluid and outer phase fluid; and (4) preparing the drug delivery carrier.

Description

technical field [0001] The invention belongs to the technical field of targeted microcarrier drug delivery, and in particular relates to a drug delivery carrier capable of controlling and speed-adjusting release of drugs by relying on external environmental stimuli and a preparation method thereof. Background technique [0002] Due to its depot structure and relatively fast environmental response rate, the smart microcapsule carrier system is considered to be the most ideal smart drug delivery carrier, especially suitable for targeted drug delivery of drugs with large toxic side effects and poor stability. The high dose can also improve the stability of the drug, and make the drug only released in the lesion, without producing toxic and side effects in other normal parts. Therefore, the intelligent microcapsule carrier system is considered to be one of the important means to achieve targeted drug delivery and conquer difficult diseases such as cancer, and has become a resear...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/02A61K47/32
Inventor 巨晓洁魏竭谢锐褚良银
Owner SICHUAN UNIV
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