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A kind of method for preparing total alkaloids of Bo Luohui

A technology of total alkaloids and botanicals, which is used in drug combinations, pharmaceutical formulations, plant raw materials, etc., to shorten the process cycle, reduce energy consumption and production costs, and improve extraction efficiency.

Active Publication Date: 2011-11-30
HUNAN HANQING BIOLOGICAL
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0003] (1) The traditional Chinese medicine Boluohui total alkaloid extraction technology is to use acid water extraction, add alkali to precipitate, filter the precipitate, extract the precipitate with organic solvent, and then use the method of acid crystallization to form salt. The shortcomings of this technology After adding alkali to precipitate, a large amount of alkali-containing organic wastewater will be produced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Crush 500 kg of pods into 40-60 mesh, add them to ultrasonic countercurrent extraction equipment, add 2500 kg of 90% ethanol from the other end for countercurrent ultrasonic extraction, ultrasonic frequency is 30-60KHz, ultrasonic time is 15-75 Minutes, ultrasonic power 12-76KW, extraction temperature 50-80°C, liquid flow meter and feed speed controller to control the ratio of material to liquid to 1:5, the extract liquid is separated from the slag liquid by the slag liquid separator, and the extract liquid feed liquid Treatment system: Add 25 kg of 5ppm ZTC 1+1 natural clarifier to the sedimentation tank to precipitate to remove some macromolecular substances such as protein, tannin, polysaccharide, etc., add 30 kg of 5ppm diatomaceous earth to aid in filtration, and filter Boluo back to the crude extract Aqueous concentrated liquid, coarse filtration (activated carbon + quartz sand), three-stage hollow fiber membrane filtration, remove mechanical impurities in the solu...

Embodiment 2

[0033] Crush 500 kg of pods into 40-60 meshes, add them to ultrasonic countercurrent extraction equipment, add pure water from the other end for countercurrent ultrasonic extraction, ultrasonic frequency is 30-60KHz, ultrasonic time is 15-75 minutes, ultrasonic The power is 12-76KW, the extraction temperature is 50-80°C, the liquid flow meter and the feed speed controller are used to control the ratio of material to liquid to 1:5, the extract is separated from the slag by the slag-liquid separator, and the extract is fed to the liquid treatment system; Add 25 kg of 5ppm ZTC 1+1 natural clarifier to the precipitation tank to precipitate and remove some macromolecular substances such as protein, tannin, polysaccharide, etc., add 30 kg of 5ppm diatomite to aid in the filter, and filter Boluo back to the crude extract aqueous solution concentrate , coarse filtration (activated carbon + quartz sand), three-stage hollow fiber membrane filtration, remove mechanical impurities in the s...

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PUM

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Abstract

The invention discloses a macleaya cordata total alkaloid preparation method. According to the preparation method provided by the invention, technologies of supersonic-wave continuous countercurrent extraction, ceramic membrane purification, sodium filter membrane condensation, intelligent static microwave vacuum drying technology and the like are adopted to prepare the macleaya cordata extract so as to raise the extraction efficiency of macleaya cordata with one-time extraction rate being over 0.7-1%; in addition, the total alkaloid has high purity and good quality; the preparation technology is simple, the technology period is shortened, the energy consumption and production cost are reduced, there is no pollution during the technology process, and the preparation method is applicable to large-scale industrial cleaning production. Waste residues generated after the extraction of the macleaya cordata total alkaloid can be used as organic fertilizers or fuels for reutilization, thus leading to the full application and development of the macleaya cordata resource.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine biopharmaceuticals, in particular to a method for preparing total alkaloids of the traditional Chinese medicine Boluohui. Background technique [0002] The total alkaloids of Boluohui come from the whole plant and fruit pods of Boluohui, a plant of Papaveraceae. It belongs to the benzophenanthridine alkaloids. Anesthesia has been used as a medicine in my country for more than one thousand years. Research at home and abroad has found that the extract of Boluohui can be developed into antiviral human and veterinary drugs and feed additives, organic insecticides, and fungicides. The total alkaloids of Boluohui are antibacterial, anti-inflammatory, heat-clearing and detoxifying, and anti-tumor substances. , Shampoo, skin care cream, surgical soap, disinfectant and other daily necessities and medical supplies. Boluohui fruit pod extract mainly contains benzylisoquinoline total alkaloids, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61K8/97A61P31/04A61P35/00A61P33/00A61K8/9789
Inventor 满汉云满孜孜满意
Owner HUNAN HANQING BIOLOGICAL
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