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Gradually degradable woven ureter scaffold tube and preparation method thereof

A technology for ureteral stents and degradation speed, applied in the field of braided ureteral stents and its preparation, and textile biomedical materials, can solve problems such as blockage, single degradable materials, large stent fragments, etc., achieve high economic benefits, and simple preparation process , the effect of good identity

Active Publication Date: 2014-04-16
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the repair process of the stent, due to the single degradation material and the same degradation rate, the overall degradation of the pipeline leads to the disintegration of the ureteral stent and the formation of larger stent fragments, resulting in new blockages

Method used

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  • Gradually degradable woven ureter scaffold tube and preparation method thereof
  • Gradually degradable woven ureter scaffold tube and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040]First, PGA (30dtex / 8f) multifilament fiber and PGLA (30dtex / 8f) multifilament fiber are braided into twisted yarns on the braiding machine, one of which is made of a PGA (30dtex / 8f) multifilament fiber and a Root PGLA (30dtex / 8f) multifilament fiber composition, such as figure 2 As shown, it is a schematic diagram of a diamond-shaped braiding structure. The twisted yarns are respectively poured onto the spindles of a 16-spindle braiding machine. The take-up ratio of the braiding machine is 5, and the yarn is braided on the first core with a diameter of 0.6mm by using a diamond-shaped braiding method. On the mould, the length of the braided tube is 16.0cm; shape it in a vacuum oven at 110°C for 10 minutes, and then remove the braided layer from the first mandrel to form a stent tube; The inner diameter of the tube and the second mandrel with a length of 3.0cm are wrapped around a polytetrafluoroethylene solid rod with a diameter of 1.0cm to form a single ring, and then s...

Embodiment 2

[0043] First, weave PGA (60dtex / 16f) and PGLA (60dtex / 16f) multifilament fibers into two kinds of yarns on the braiding machine, one of which is composed of two PGA multifilament fibers, and the other is composed of two PGLA multifilament fibers Composition, the two kinds of yarns are distributed according to the rule of 1 every 1 and poured on the spindles of the 24-spindle braiding machine. The take-up ratio of the braiding machine is 6, and the yarn is braided on the first core with a diameter of 3.0mm by using a diamond braiding method. On the mould, the length of the braided tube is 59.0cm; shape the braided layer from the first mandrel in a vacuum oven at 145°C for 6.5 minutes to form a stent tube; insert a diameter smaller than the stent tube at both ends of the preliminarily shaped stent tube The second mandrel with an inner diameter and a length of 15.7cm is wrapped twice around a solid polytetrafluoroethylene rod with a diameter of 2.5cm to form two rings, and then sh...

Embodiment 3

[0046] First, PGA (100dtex / 24f) and PGLA (100dtex / 24f) multifilament fibers are woven into a yarn on a braiding machine, wherein each yarn is composed of two PGA multifilament fibers and one PGLA multifilament fiber, which are poured separately On the spindle of the 32-spindle braiding machine, the take-up ratio of the braiding machine is 7, the yarn is braided on the first mandrel with a diameter of 5.8mm by using a diamond braiding method, and the length of the braiding tube is 74.2cm; in a vacuum oven at 180°C In 3.0 minutes of setting, the braided layer is removed from the first mandrel to form a stent tube; the two ends of the initially shaped stent tube are respectively inserted into a second mandrel with a diameter smaller than the inner diameter of the stent tube and a length of 14.6 cm. A 4.0cm polytetrafluoroethylene solid rod is formed into a pigtail shape, and then shaped in a vacuum oven at 180°C for 3.0min, then it is withdrawn from the polytetrafluoroethylene sol...

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Abstract

The invention relates to a gradually degradable woven ureter scaffold tube and a preparation method thereof. The woven ureter scaffold tube comprises a tube body. The woven ureter scaffold tube is characterized in that: the tube body is woven by using at least two fiber raw materials with different degradation rates. The preparation method is characterized by comprising the following steps of: making the at least two fiber raw materials with different degradation rates into yarns, weaving the obtained yarns on a first core die by adopting a rhombic structure on a 16 to 32-spindle weaving machine to form a woven tube, stripping the woven tube from the first core die to form the tube body after heat setting, performing secondary heat setting, and coating the tube body by using chitosan to make the tail end of the annular structure. According to the woven ureter scaffold tube, gradient degradation can be realized, the degradation time is controllable, the degraded product is smaller than 1mm<3>, the structure is fixed, and the mechanical property is good.

Description

technical field [0001] The invention relates to a gradually degradable braided ureteral stent and a preparation method thereof, belonging to the field of textile biomedical materials and technologies. Background technique [0002] In 1967, Zimskind et al. first applied intraluminal technology to retrogradely implant a silicone rubber ureteral stent through a cystoscope, successfully alleviating ureteral obstruction. With a history of more than 40 years, ureteral stents are widely used in urological operations such as upper urinary tract obstructive lesions, nephroureteral calculus, urinary system trauma, and upper urinary tract reconstruction. The main function of a ureteral stent is to keep the ureter open and drain urine into the bladder. [0003] The main components of currently used ureteral stents are non-absorbable polyurethane, silicone rubber and metal materials, which need to be taken out again after surgery, and have poor tissue compatibility. Easy to form stones...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61M25/14
Inventor 王璐陈方王文祖尚亚峰邹婷王富军周君梅谢华关国平黄轶晨林婧吕逸清
Owner DONGHUA UNIV
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