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A method for preparing porous calcium phosphate bioceramic material

A bioceramic material, porous calcium phosphate technology, applied in the field of materials and biomedicine, can solve the problems of easy inflammation, residual plastic particles, complicated process, etc., achieve uniform pore size and pore distribution, simple method and high purity Effect

Inactive Publication Date: 2011-12-14
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method is complex and will leave plastic particles, which can easily cause inflammation

Method used

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  • A method for preparing porous calcium phosphate bioceramic material
  • A method for preparing porous calcium phosphate bioceramic material
  • A method for preparing porous calcium phosphate bioceramic material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Put the OCP (octacalcium phosphate) powder into a stainless steel mold, compact it under the condition of a pressure of 20MPa, and then keep it under this pressure for 10 minutes, and then take out the green body; o The heating rate of C / min rises to 300 o Sintering at C, vaporization to remove crystal water, keep it at this temperature for 2h and then heat to 900 o C undergoes a phase change and then is naturally cooled in the furnace to obtain β-TCP porous bioceramics with a pore diameter of 1 to 5 μm and a porosity of 22%.

Embodiment 2

[0042] Put DCPD (calcium hydrogen phosphate dihydrate) powder into a stainless steel mold, compact it under the condition of a pressure of 20MPa, and then keep it under this pressure for 10 minutes, and then take out the green body; o The heating rate of C / min rises to 300 o Sintering at C, vaporization to remove crystal water, keep it at this temperature for 2h and then heat to 900 o C undergoes a phase change, and then is naturally cooled in the furnace to obtain porous HA bioceramics with a pore diameter of 1 to 5 μm and a porosity of 37%.

Embodiment 3

[0044] The OCP and DCPD powders are mixed in a ratio of 1:1, the mixed powder is put into a stainless steel mold, and compacted under the condition of a pressure of 20 MPa, and then kept under the pressure for 10 minutes, and the green body is taken out; the result is obtained after compaction The body is 20 o The heating rate of C / min rises to 300 o Sintering at C, vaporization to remove crystal water, keep it at this temperature for 2h and then heat to 900 o C undergoes a phase change and then is naturally cooled in the furnace to obtain β-TCP and HA dual-phase porous bioceramics with a pore diameter of 1 to 5 μm and a porosity of 29%.

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Abstract

The invention discloses a method for preparing a porous calcium phosphate biological ceramic material. The method comprises the following steps of: 1) adding a hydroxylapatite pre-phase into a die casting mould, compacting and keeping certain time, and taking a compacted green body out; and 2) raising the temperature of the compacted green body to 200 to 500 DEG C and sintering, keeping the temperature for 0.5 to 2h, heating to the temperature at which the hydroxylapatite pre-phase can be changed, stopping heating after the temperature at which the phase change can be ensured is reached, and naturally cooling the green body to room temperature in sintering equipment to obtain the porous calcium phosphate biological ceramic material. The process is simple and is high in controllability, the purity is high, and the strength of the material is influenced slightly. The porous biological ceramic material prepared by the method has better biocompatibility and bioactivity.

Description

Technical field [0001] The invention relates to a preparation method of a porous calcium phosphate bioceramic material, belonging to the field of materials and biomedicine. [0002] Background technique [0003] Clinically, artificial bone scaffolds are used to artificially repair human bone tissue that has been injured or suffered disease. This repair may lead to the spread of other diseases. Compared with metal stents and polymer stents, bioceramic stents do not have free metal ions, have better biocompatibility and non-toxicity; and some polymer stents, its degradation products may cause inflammation. Calcium phosphate bioceramics (hydroxyapatite HA and tricalcium phosphate β-TCP) are mainly used as artificial bone scaffolds to repair and reconstruct hard tissue defects, and have broad application prospects in the medical field. [0004] Dense bioceramics usually do not have microstructures suitable for tissue and cell growth, and their biodegradability and osteoconductivity are...

Claims

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Application Information

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IPC IPC(8): C04B38/08C04B35/447C04B35/622
Inventor 辛仁龙左蔼龄高家诚
Owner CHONGQING UNIV
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