Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Intraoral film-like base agent and formulation

An intraoral, film-like technology, which is applied in the field of intraoral film-like bases and preparations, and can solve the stickiness, the technology of dispersing sugar particles, and the preparation of film-like preparations are not shown, etc. problem, to achieve the effect of improving disintegration and reducing stickiness

Active Publication Date: 2014-07-23
KYUKYU PHARMA
View PDF10 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, conventional oral film-form bases or preparations exhibit a sticky feeling due to water-soluble polymers when applied in the oral cavity, and sticky feeling is also a problem when touched with fingers.
In addition, in Patent Document 7 concerning rapidly dissolving preparations, there is no disclosure of techniques for dispersing fine particles of sugars, nor does it describe the preparation of film-like preparations.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Intraoral film-like base agent and formulation
  • Intraoral film-like base agent and formulation
  • Intraoral film-like base agent and formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1、2

[0080] The compositions of Examples 1 and 2 and the compositions of Comparative Examples 1 and 2 are shown in Table 3 for the oral film-form preparation of the present invention.

[0081] [table 3]

[0082]

[0083] The oral film-form preparations of Examples 1 and 2 were prepared as follows. In Table 3, 47.0 parts by weight of HPC (weight average molecular weight = about 30,000, degree of substitution of hydroxypropoxy group = 53.4 to 77.5%) or PVP K-30 (weight average molecular weight = about 40,000) was added to 70.5 parts by weight of ethanol and Stir to dissolve, and prepare an ethanol solution of HPC or PVP K-30. 9.0 parts by weight of zolmitriptan was added to the remaining ethanol, stirred and dissolved, and 40.0 parts by weight of D-mannitol fine particles previously passed through a 32 μm sieve were added and ultrasonically stirred. The ethanol solution of HPC or PVP K-30 and 4.0 parts by weight of polyethylene glycol were stirred and mixed therein, and after su...

Embodiment 3～10

[0086] Next, the composition of Examples 3-10 concerning the oral film-form preparation of this invention is shown in Table 4. They were prepared by dissolving zolmitriptan in ethanol in the same manner as the oral film-form preparations of Examples 1 and 2, then adding and dispersing sugar or sugar alcohol fine particles previously passed through a 32 μm sieve, and then adding A solution prepared by adding HPC and polyethylene glycol to 70.5 parts by weight of ethanol was stirred and mixed, and after sufficient defoaming, it was developed and dried on a polyethylene terephthalate peel-off film to produce a film with a thickness of about 100 μm. film, the resulting film was cut into 3 cm 2 The rectangle is thus prepared.

[0087] [Table 4]

[0088]

Embodiment 11～20

[0097] Table 6 shows the compositions of Examples 11 to 20 regarding the oral film-form preparation of the present invention.

[0098] [Table 6]

[0099]

[0100] The oral film preparations of Examples 11 to 16 were prepared as follows. That is, in Table 6, HPC (weight average molecular weight = about 30,000, hydroxypropoxyl substitution degree = 53.4 to 77.5%) was added to 1.5 times by weight of ethanol, stirred and dissolved, and an ethanol solution of HPC was prepared. Add the drug to the rest of the ethanol and stir to dissolve it, add D-mannitol fine particles, the aforementioned ethanol solution of HPC, and polyethylene glycol, stir and mix, and place it on a polyethylene terephthalate release film Expand and dry to produce a film with a thickness of about 100 μm, and cut the obtained film into 3 cm 2 Rectangular, made into film-like preparations.

[0101] In addition, the oral film preparations of Examples 17 to 20 were prepared as follows. That is, the drugs lis...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

In the present invention, by combining an edible polymer soluble in water and an organic solvent with a solubility parameter of 9.7 or more and sugars selected from the group consisting of monosaccharides to hexasaccharides insoluble in organic solvents and their sugar alcohols One or more kinds of particles with an average particle diameter of 0.1 to 60 μm are dispersed in the organic solvent to prepare a film-like base in which one or more of sugars and sugar alcohols are dispersed in the state of fine particles, and then make it contain drugs, Made into a film-like preparation. As a result, it is possible to provide an oral film-form base and preparation having a rapid dissolution profile in the oral cavity and sufficient film strength, and furthermore, the sticky feeling caused by the water-soluble polymer in the oral cavity is reduced, indicating The tactile feel upon touch is also improved.

Description

technical field [0001] The present invention relates to an oral film-like base that dissolves rapidly in the oral cavity and a preparation containing a drug in the base. More specifically, it relates to a base in which fine particles of sugar and sugar alcohol are dispersed. Oral film-like bases and preparations made in the oral cavity, which dissolve rapidly in the oral cavity, so that the drug can be well absorbed by the digestive organs or oral mucosa. Background technique [0002] As current orally applicable pharmaceuticals, solid preparations such as bare tablets, coated tablets, capsules, powders, and granules, and liquid preparations such as liquids and emulsions have appeared on the market. Orally disintegrating tablets and fast-dissolving oral film preparations are already on the market as preparations that disintegrate in the oral cavity and are absorbed by the digestive tract. [0003] Film-shaped, tape-shaped or sheet-shaped preparations that are applied in the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/10A61K47/26A61K47/32A61K47/38
CPCA61K9/0056A61K47/26A61K9/7007A61K47/38A61P1/04A61P1/08A61P13/08A61P25/06A61P37/08A61P9/12A61P3/10A61K9/70A61K47/32
Inventor 浅利大介堀光彦小川景子
Owner KYUKYU PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com