Formula with sounding effect and preparation method thereof

A technology of action and sound, applied in the field of formulation and preparation of traditional Chinese medicine oral liquid, can solve the problems of children and the elderly being difficult to use, difficult to control the quality, etc.

Inactive Publication Date: 2012-02-29
WUXI JIMIN KEXIN SHANHE PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After years of clinical observation, the treatment of laryngeal inflammation, hoarseness and aphonia has obvious curative effect, and it has obvious curative effect on vocal cord nodules and polyps. There are no adverse reactions reported in long-term clinical observation, and it has won unanimous praise from doctors and patients.
However, the existing pills adopt the traditional technology, the quality is difficult to control, and it is difficult for children and the elderly to use. For this reason, the present invention is based on the existing technology and is prepared into a sound oral liquid through process improvement.

Method used

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  • Formula with sounding effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Get 5 parts of Rhubarb, 15 parts of Fritillaria and 10 parts of Platycodon grandiflorum and pulverize into coarse powder, press the percolation method operation under the Chinese Pharmacopoeia 2005 edition one appendix I0 medium liquid extract and extract item, use 60% ethanol as solvent, Percolation, recovery of ethanol, and concentration into a thick paste with a relative density of 1.33 at 80°C for subsequent use;

[0026] Take 5 parts of Rhizoma Chuanxiong, 10 parts of Forsythia and 10 parts of Peppermint to extract the volatile oil, mix the dregs with 1 part of Panda Dahai, 5 parts of cicada slough, 5 parts of myrobalan meat, 10 parts of catechu, and 10 parts of licorice, add water and decoct three times, three times The decocting time is as follows: 1.5 hours, 1.5 hours, 1 hour, filter, combine the filtrate, and concentrate the filtrate into a clear paste with a relative density of 1.20 at 80°C, and set aside;

[0027] (3) Take 10 parts of sucrose, add an appropri...

Embodiment 2

[0030] Get 25 parts of Rhubarb, 60 parts of Fritillaria and 60 parts of Campanulaceae and pulverize into coarse powder, press Chinese Pharmacopoeia 2005 edition one appendix I0 middle liquid extract and the percolation method operation under the extract item, use 60% ethanol as solvent, Percolation, recovery of ethanol, and concentration into a thick paste with a relative density of 1.33 at 80°C for subsequent use;

[0031] Take 25 parts of Rhizoma Chuanxiong, 50 parts of Forsythia and 50 parts of Peppermint to extract volatile oil, mix the dregs with 5 parts of Panda Dahai, 25 parts of cicada slough, 25 parts of myrobalan meat, 50 parts of catechu, and 50 parts of licorice, add water and decoct three times, three times The decocting time is as follows: 1.5 hours, 1.5 hours, 1 hour, filter, combine the filtrate, and concentrate the filtrate into a clear paste with a relative density of 1.20 at 80°C, and set aside;

[0032] (3) Take 50 parts of sucrose, add an appropriate amoun...

Embodiment 3

[0034] Embodiment 3: animal acute toxicity test

[0035] Acute Toxicity Study Drugs of Huangshi Xiangsheng Oral Liquid

[0036] Tested drug: Huang's sound oral liquid extract (extracted and processed from 12 Chinese herbal medicines such as mint, fritillary mother, fat sea, cicada slough, wine rhubarb, forsythia, bellflower, catechu, myrobalan meat, chuanxiong, licorice, and menthol Made), it is dark brown, and each gram of extract is equivalent to 2.39 grams of crude drug.

[0037] Preparation method: Dilute the extract with distilled water to make a 63.89% solution

[0038] Animals Kunming mice (Experimental Animal Center of Suzhou Medical College); body weight 21.3±0.8g (X±SD); sex: half male and half male; number of animals: 40.

[0039] Experimental method and results

[0040] Take 20 Kunming mice, half male and half female. After fasting for 12 hours, each mouse was given 0.4ml / 10g body weight of 63.89% Huangshi Xiangsheng Oral Liquid Extract orally, that is, 0.4×0.63...

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Abstract

The invention discloses an oral liquid with a sounding effect and a preparation method thereof. The oral liquid is prepared through extracting twelve Chinese herbal medicines consisting of mint, Fritillaria thunbergii Miq., Sterculia lychnophora, periostracum cicadae, wined Rheum officinale, Weeping Forsythia, Platycodon grandiflorum, catechu, Terminalia meat, Ligusticum wallichii, licorice and menthol, and processing. The oral liquid which has the efficacies of wind dispelling and lung diffusing, heat clearing and phlegm reducing, and throat disinhibiting and sounding is suitable for treating acute pharyngolaryngitis, chronic pharyngolaryngitis, and symptoms of throat drying, vocal cord hyperemia, vocal cord oedema, glottic chink and the like.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a formula and a preparation method of a traditional Chinese medicine oral liquid with sound effect. Background technique [0002] With the acceleration of the pace of life, overwork or poor diet often cause hoarseness and pharyngeal discomfort, and in daily life, acute and chronic pharyngitis is one of the common respiratory diseases. And often because of severe pain affect eating, breathing and sleep. At present, there are many medicines for the treatment of this disease, but the problem of unsatisfactory treatment effect generally exists. [0003] Huang's Xiangsheng Wan is a traditional Chinese medicine product developed according to the ancestral secret recipe of Jiangsu Huang's Laryngology donated by a famous old doctor of Laryngology in China. It has been included in the National Basic Medicine Catalogue. After years of clinical observation, the treatment of la...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61P11/04A61K35/64A61K35/644
Inventor 易斌过晓磊
Owner WUXI JIMIN KEXIN SHANHE PHARMA
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