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Bactericidal composition containing isotianil and iprobenfos

A technology of isothiazide and isothiazide, applied in the field of pesticides, can solve the problems of reducing the efficacy of fungicides, high loss rate, pesticide pollution and the like

Inactive Publication Date: 2021-08-10
合肥巨卓农业技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the above-mentioned technical problems, the object of the present invention is to provide a bactericidal composition containing Isotianil and Isoblastin: by adding the slow-release agent into deionized water, the sustained-release liquid is obtained after dissolving, and the isotianil Add tifluzamide to methanol for dissolution, then add isoplastin to obtain a mixed solution, add the mixed solution dropwise to the slow-release solution, adjust the pH of the reaction system with hydrochloric acid solution and sodium hydroxide solution, and then ultrasonically and rotary evaporate, Obtaining the bactericidal composition containing Isotianil and Isoblastin solves the high loss rate of the existing bactericidal composition in use due to the burst release phenomenon, which greatly reduces the efficacy of the bactericide. At the same time, The sudden release of fungicides is likely to cause serious pesticide pollution to the environment

Method used

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  • Bactericidal composition containing isotianil and iprobenfos
  • Bactericidal composition containing isotianil and iprobenfos

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The present embodiment is a sustained-release agent, and the preparation process of the sustained-release agent is as follows:

[0034] S1: Add maleic anhydride to a three-necked flask equipped with a nitrogen conduit, a reflux condenser, and a stirrer, place the three-necked flask in a constant temperature oil bath, and heat while stirring at a stirring speed of 100r / min. Control the heating rate at 2°C / min, raise the temperature to 60°C and continue to stir until the maleic anhydride is completely melted, add the catalyst and nonylphenol, then raise the temperature to 82°C and reflux for 4 hours, cool to room temperature after the reaction, Intermediate 1 is obtained; the molar ratio of maleic anhydride and nonylphenol is controlled to be 1:1.00, the catalyst is anhydrous sodium acetate, and the amount of catalyst is 0.1% of the total weight of maleic anhydride and nonylphenol;

[0035] S2: Add sodium hydroxymethyl cellulose to aqueous acetic acid solution, stir and s...

Embodiment 2

[0040] The present embodiment is a sustained-release agent, and the preparation process of the sustained-release agent is as follows:

[0041] S1: Add maleic anhydride to a three-necked flask equipped with a nitrogen conduit, a reflux condenser, and a stirrer. The three-necked flask is placed in a constant temperature oil bath and heated while stirring at a stirring speed of 200r / min. Control the heating rate to 4°C / min, heat up to 60°C and continue to stir until the maleic anhydride is completely melted, add the catalyst and nonylphenol, then raise the temperature to 85°C and reflux for 4.5 hours, cool to room temperature after the reaction , obtain intermediate 1; control the mol ratio of maleic anhydride and nonylphenol to be 1:1.03, the catalyst is anhydrous sodium acetate, and the consumption of catalyst is 0.2% of the total weight of maleic anhydride and nonylphenol;

[0042] S2: Add hydroxymethyl cellulose sodium to the aqueous acetic acid solution, stir and swell for 3...

Embodiment 3

[0047] The present embodiment is a sustained-release agent, and the preparation process of the sustained-release agent is as follows:

[0048] S1: Add maleic anhydride to a three-necked flask equipped with a nitrogen conduit, a reflux condenser, and a stirrer, place the three-necked flask in a constant temperature oil bath, and heat while stirring at a stirring speed of 300r / min. Control the heating rate at 5°C / min, heat up to 60°C and continue to stir until the maleic anhydride is completely melted, add the catalyst and nonylphenol, then raise the temperature to 88°C and reflux for 5 hours, cool to room temperature after the reaction, Intermediate 1 is obtained; the molar ratio of maleic anhydride and nonylphenol is controlled to be 1:1.05, the catalyst is anhydrous sodium acetate, and the amount of catalyst is 0.3% of the total weight of maleic anhydride and nonylphenol;

[0049] S2: Add sodium hydroxymethyl cellulose to aqueous acetic acid solution, stir and swell for 4 hou...

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Abstract

The invention discloses a bactericidal composition containing isotianil and iprobenfos, and relates to the field of pesticides. A sustained-release agent is added into deionized water and dissolved to obtain a sustained-release solution, isotianil is added into methanol and dissolved, then iprobenfos is added to obtain a mixed solution, the mixed solution is added into the sustained-release solution drop by drop, the pH value of the reaction system is adjusted by using a hydrochloric acid solution and a sodium hydroxide solution, and then ultrasonic treatment and rotary evaporation are carried out to obtain the bactericidal composition containing isotianil and iprobenfos. The sustained-release agent is added into the isotianil and the iprobenfos to coat the isotianil and the iprobenfos to form the drug-loaded nanocapsule, and the sustained-release agent has an amphiphilic structure, has high dispersity and can be dispersed in most solvents, so that the dosage form of the bactericidal composition is increased, the application range of the bactericidal composition is widened, meanwhile, after a formed drug-loaded nanocapsule is applied, the pesticide attached to the surface of the drug-loaded nanocapsule can play a role firstly, the rest of the pesticide in the drug-loaded nanocapsule is slowly released, and a long-acting sterilization effect can be achieved.

Description

technical field [0001] The invention relates to the field of pesticides, in particular to a fungicidal composition containing Isotianil and Isoblastin. Background technique [0002] Pesticides are substances that play an important role in the prevention and control of crop diseases and insect pests. Isotianil is a fungicide and an activator for rice blast. It has inductive activity, fungicidal activity, and certain insecticidal activity. Its characteristics The reason is that it does not have a direct antibacterial effect on pathogenic bacteria, but achieves the purpose of resisting rice blast by stimulating the rice's own natural defense mechanism against rice blast. Yidaojing, an organophosphorus fungicide, mainly interferes with cell membrane permeability , preventing some lipophilic chitin precursors from passing through the plasma membrane, hindering the synthesis of chitin, preventing the growth of the cell wall, and inhibiting the normal development of the bacteria. B...

Claims

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Application Information

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IPC IPC(8): A01N43/80A01N57/14A01N25/28A01P3/00C08B13/00
CPCA01N25/28A01N43/80A01N57/14C08B13/00
Inventor 刘言合陈琦
Owner 合肥巨卓农业技术开发有限公司
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